RT Journal Article
ID 0d4cd68503a152bf
A1 Ringhieri, Paola
A1 Morelli, Giancarlo
A1 Accardo, Antonella
T1 Supramolecular Delivery Systems for Non-Platinum Metal-Based Anticancer Drugs
JF Critical Reviews™ in Therapeutic Drug Carrier Systems
JO CRT
YR 2017
FD 2017-05-05
VO 34
IS 2
SP 149
OP 183
K1 metal-based drugs
K1 delivery systems
K1 liposomes
K1 micelles
K1 supramolecular aggregates
K1 polymeric particles
AB Stimulated by the enormous success of the inorganic complex cisplatin in tumor treatment, interest in metal complexes has recently grown. Within cells, metal complexes
can participate in reactions that are not possible with conventional organic substances, and most of them have promising efficacy as anticancer drugs. However, to be effective in vivo metal complexes need adequate delivery systems able to increase their water solubility, the in vivo bioavailability, and the safe delivery to target organs. The present review reports on the state of the art of these new, nonplatinum, anticancer metallodrugs delivered by nanosized vehicles. The development of complexes of ruthenium, gold, cobalt, copper, gallium, and others that show promising antitumor efficacy is reported, and we emphasize the different approaches in the individuation of the most appropriate delivery system for each of them.
PB Begell House
LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,6e6a4dc966d8787f,0d4cd68503a152bf.html