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International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018026043
pages 411-418

Isolation and Structure Determination of Antiproliferative Secondary Metabolites from the Potato Earthball Mushroom, Scleroderma bovista (Agaricomycetes)

Bernadett Kovacs
Department of Pharmacognosy, University of Szeged, Szeged, Hungary
Zoltán Béni
Spectroscopic Research, Gedeon Richter Plc., Budapest, Hungary
Miklós Dékány
Spectroscopic Research, Gedeon Richter Plc., Budapest, Hungary
Noémi Bózsity
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Istvan Zupko
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Judit Hohmann
Department of Pharmacognosy, University of Szeged, Szeged, Hungary; Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary
Attila Vanyolos
University of Szeged, Department of Pharmacognosy 6720 Szeged Eötvös u. 6., Hungary

ABSTRAKT

Mycochemical examination of a methanol extract of Scleroderma bovista Fr. (Agaricomycetes) led to the isolation of 7 compounds, which were, to our knowledge, identified for the first time in this species. The chemical structures of these compounds were determined through extensive spectroscopic methods (nuclear magnetic resonance and mass spectrometry). The fungal metabolites were identified as steroids based on ergostane (compounds 1-4) and lanostane (compounds 6 and 7) skeletons, whereas compound 5 was a ceramide derivative. We evaluated the antiproliferative activity of compounds 4-7 against human cancer cell lines (HeLa, A2780, MDA-MB-231, and MCF-7) using the MTT assay. The lanostane-type derivatives (compounds 6 and 7) and ergosterol peroxide 3-glucoside (compound 4) exerted significant antiproliferative property on 1 or more human cancer cell lines.


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