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International Journal of Medicinal Mushrooms

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ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Comparative Study on the Effect of Aqueous and Ethanolic Mycelial Extracts from Polycephalomyces nipponicus (Ascomycetes) against Human Breast Cancer MCF-7 Cells

Volumen 21, Ausgabe 7, 2019, pp. 671-681
DOI: 10.1615/IntJMedMushrooms.2019031140
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ABSTRAKT

Recently, the entomopathogenic fungus Polycephalomyces nipponicus has been determined to be a prolific producer of bioactive compounds that have both antibacterial and antimarial activities, but the anticancer effects of the mycelial extracts have not been well studied. The present study investigates the effects and mechanisms of action of P. nipponicus extracts that are responsible for cell death in the human breast cancer MCF-7 cell line. The results showed that the 50% ethanol extract had greater anticancer activity than the aqueous extract. The 50% ethanolic extract inhibited cell growth at concentrations of just 109.75 ± 3.54 µg mL-1 for 72 h. The aqueous extract's activity was > 400 µg mL-1 against MCF-7 cells. Similar results were obtained from the colony formation assay. Moreover, the 50% ethanolic extract caused a significant increase in the distribution of cells at the G1 phase in a dose-dependent manner. The aqueous extract induced MCF-7 cells to arrest at the G2/M phase in a dose-dependent manner. These were supported by the reduction in the cyclin-dependent kinase (cdk)2, cdk4, and cdk6 genes' expression levels along with an induction of the cyclin-dependent kinase inhibitor p21 in MCF-7 cells after treatment with the extracts. In conclusion, P. nipponicus may be useful for breast cancer prevention and treatment in the future.

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REFERENZIERT VON
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