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International Journal of Medicinal Mushrooms
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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i2.40
pages 147-152

Studies on the Triterpenoid Constituents of the Spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)

Ruo-Yun Chen
Department of Chemistry of Natural Products Institute of Materia Medica, Chinese Academy of Medical Science, Beijing, R.P. China
De-Quan Yu
Department of Chemistry of Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China

ABSTRAKT

Five compounds were isolated from the ether-soluble fraction of the spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. On the basis of their chemical properties and spectral data (MS, UV, IR, 1H, and 13C-NMR), they were identified as 3,7,11,12,15,23-hexaoxo-5α-lanosta-8-en-26-oic acid (I); ganoderic acids B (II), C (III), and E (IV); and ganodermanontriol (V). Compound I is a new natural product named ganosporeric acid A. Compounds II, III, IV, and V are known compounds and were obtained for the first time from the spores of G. lucidum. Pharmacological experiments showed that ganosporeric acid A has GPT-lowering activity in mice with liver injury caused by CCI4 and GaNI and exhibits hepaoprotective effects.


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