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International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i2.90
pages 187-190

Thrombolytic Activity of Mushroom Proteinases: Thrombolytic Activity of Proteinases from Coprinus domesticus, C. cinereus, and Cerrena unicolor

Nina P. Denisova
V. L. Komarov Botanical Institute Russian Academy of Sciences Prof. Popova Str. 2 St. Petersburg 197376, Russia
Vladimir N. Mikhailov
Department of Pathological Physiology, Acad. I. P. Pavlov Saint Petersburg State Medical University, L.Tolstoy Str., 6/8, Saint Petersburg 197022(1), Russia
Nickolay N. Petrishchev
Department of Pathological Physiology, Acad. I. P. Pavlov Saint Petersburg State Medical University, L.Tolstoy Str., 6/8, Saint Petersburg 197022(1), Russia

ABSTRAKT

Fibrinolytic and thrombolytic activity of extracellular enzyme complexes from the cultures of coprotrophic mushrooms Coprinus domesticus (Bolt.: Fr.) S. F. Gray and С. Cinnereus (Schaeff.: Fr.) S. F. Gray, as well as xylotrophic mushroom, Cerrena unicolor (Bull.: Fr.) Murr., were investigated during biomedical experiments in vitro and in vivo. It was shown that enzyme complexes isolated from C. domesticus, C. cinereus, and Cerrena unicolor possess a large affinity for fibrin and cause fibrin lysis. In addition, a direct and stable thrombolytic effect developed, proving more significant in fresh thrombosis.


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