Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024522
pages 967-980

Antioxidant and Genotoxic Properties of Hispidin Isolated from the Velvet-Top Mushroom, Phaeolus schweinitzii (Agaricomycetes)

Lina Smolskaite
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania
Gražina Slapšyte
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Jurate Mierauskiene
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Veronika Dedonyte
Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Petras Rimantas Venskutonis
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania

ABSTRAKT

Antioxidant and genotoxic properties of hispidin isolated from the Phaeolus schweinitzii mushroom were evaluated with various assays. Hispidin demonstrated strong free radical scavenging, oxygen radical absorbance capacity, and ferric-reducing antioxidant power; in all applied assays, hispidin exhibited antioxidant capacity similar to or higher than that of the reference antioxidant Trolox. Genotoxic activity of hispidin was assessed using different end points: chromosome aberrations, micronuclei, sister chromatid exchanges, and primary DNA damage (detected by the comet assay) in human lymphocytes in vitro, and gene mutations in the Salmonella/microsome test. Hispidin did not increase the frequency of chromosome aberrations, micronuclei, or primary DNA damage in human lymphocytes in vitro and did not produce reverse mutation in bacterial cells. However, we identified in human lymphocytes a statistically significant dose-dependent increase in sister chromatid exchange frequency and a decrease in replication index and nuclear division index values.


Articles with similar content:

Modulatory Effect of Phenolic Fractions of Terminalia arjuna on the Mutagenicity in Ames Assay
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 1
Saroj Arora, Kamaljit Kaur, Subodh Kumar, Avinash Nagpal
Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 11
Bruno Tirillini, Roberto Venanzoni, Roberto Maria Pellegrino, Roberto Fabiani, Patrizia Rosignoli, Andrea Arcangeli, Giancarlo Bistocchi, Gabriele Cruciani, Andrea Rubini, Paola Angelini
Mycelial Submerged Culture of New Medicinal Mushroom, Humphreya coffeata (Berk.) Stey. (Aphyllophoromycetideae) for the Production of Valuable Bioactive Metabolites with Cytotoxicity, Genotoxicity, and Antioxidant Activity
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 4
Benjamin Rojano, Norma A. Valdez-Cruz, Sandra M. Porras-Arboleda, Mauricio Trujillo-Roldan, Leticia Rocha-Zavaleta, Cecilia Aguilar
Neurotrophic Properties of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 6
Sri Nurestri Abdul Malek, Kah-Hui Wong, Puei-Lene Lai, Noorlidah Abdullah, Umah Rani Kuppusamy, Murali Naidu, Rosie Pamela David, Vikineswary Sabaratnam
Chemical Composition and Antiproliferative, Antioxidant, and Proapoptotic Effects of Fruiting Body Extracts of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), from India
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 7
Balraj Singh Gill, Prateek Sharma, Sanjeev Kumar, Navgeet