Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i2.30
pages 123-132

Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetidae), Derived Polysaccharides Exert Immunomodulatory Activities In Vitro and In Vivo

Leilei Fang
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Yanqing Zhang
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Junbo Xie
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Lijuan Wang
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Huan Zhang
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Weilu Wei
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China
Yingrui Li
Department of Pharmaceutical Engineering, Tianjin University of Commerce, Tianjin, China; and Tianjin Key Laboratory of Food Biotechnology, Tianjin, China

ABSTRAKT

The royal sun mushroom, Agaricus brasiliensis is a widely consumed mushroom around the world. In this study, the immunoregulatory potential of A. brasiliensis polysaccharides was investigated in vitro and in vivo. In vivo, the polysaccharides remarkably increased the spleen and thymus indexes in mice, and this effect was influenced significantly by age (the adult and the juvenile). The spleen index increased by 27.28% in adult mice treated with the polysaccharides, whereas the increase in juvenile mice was just 12.59% at the dose of 150 mg·kg−1·d−1. Moreover, the effect of the polysaccharides on the thymus and spleen indexes in adult mice was obvious both in males and females. The carbon clearance ability (phagocytic index) was improved with increasing doses, (32.81% at 120 mg·kg−1·d−1, and 38.34% at 150 mg·kg−1·d−1) in mice treated with the polysaccharides. In vitro, the polysaccharides increased the RAW264.7 cell proliferation with 34.78% at 25 µg/mL and 26.78% at 50 µg/mL. Furthermore, the polysaccharides also promoted mRNA expressions of interleukin (IL)-6, IL-1β, cyclooxygenase-2, and Toll-like receptor 4 (TLR4), myeloid differentiation 88 (MYD88), and TIR-domain-containing adapter-inducing interferon-β (TRIF) in the cells, indicating that the polysaccharides induce the secretion of inflammatory cytokines by stimulating TLR4/MyD88 and TLR4/TRIF pathways. In conclusion, these results suggest that A. brasiliensis polysaccharides induce a very promising immunostimulation effect in vivo and in vitro. Therefore, it should be explored as a novel natural functional food additive.


Articles with similar content:

Immunomodulatory Activities of Polysaccharides from White Button Mushroom, Agaricus bisporus (Agaricomycetes), Fruiting Bodies and Cultured Mycelia in Healthy and Immunosuppressed Mice
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 1
Dinghe Wang, Ling Su, Yu Li, Dandan Zheng, Qi Wang, Yang Liu
Purification and Characterization of a Novel Small-Molecule Polysaccharide from the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Yanfang Liu, Aizhong Wu, Changyan Zhou, Wei Jia, Yanru Qiao, Qing-jiu Tang Tang
Lectin from Tricholoma mongolicum S. Imai (Agaricomycetideae) Mycelia Stimulates Gene Expression of Immunomodulating Cytokines in Mouse Peritoneal Macrophages and Splenocytes
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Ming Chiu Fung, Vincent Eng Choo Ooi, Fang Liu, Hexiang Wang, Tzi Bun Ng
Macrophages Stimulated by Polysaccharide Purified from Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae) Enhance mRNA Expression of Th1 Cytokine Including IL-12 and 18
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Nobuhide Fujitake, Sachiko Kawakami, Masashi Mizuno
Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 5
Mohitosh Mandal, Birendra Behera, Sujit Kumar Bhutia, Swatilekha Maiti, Tapas K Maiti, Sanjaya Kumar Mallick