Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i8.10
pages 651-660

Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review)

Joseph M. Wu
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Barbara B. Doonan
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Tze-chen Hsieh
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Qingyao Yang
Institute of Microbiology and Immunology, Shanghai Normal University, Shanghai, People's Republic of China
Xiao-Tong Yang
Institute of Microbiology and Immunology, Shanghai Normal University; and Department of Pathology, the University of Hong Kong, R.P. China
Ming-Tat Ling
Laboratory of Cancer Therapeutic Development, Australian Prostate Cancer Research Centre, Queensland University of Technology, Queensland, Australia

ABSTRAKT

The medicinal mushroom Trametes versicolor has been well recognized for its activity in maintaining the general health of the population and in managing and treating human diseases in various cultures. Its use has been recently gaining acceptance and popularity in Western countries. The reported health benefits of T. versicolor led to a search for the identity of its bioactive ingredients. These efforts have resulted in the isolation of the polysaccharopeptide PSP from cultured mycelia of strain Cov-1, which expresses large amounts of PSP. The availability of highly purified PSP was followed by studies of its biological activities using tissue culture models and limited human clinical trials. In this review we summarize recent advances in the antitumorigenic and immunomodulatory effects of PSP, elimination of prostate cancer stem cells and control of the intestinal microbiome, and its interplay with host cells as a prebiotic. These findings may have implications for widening and repurposing the use of PSP


Articles with similar content:

Medicinal Properties of Substances Occurring in Higher Basidiomycetes Mushrooms: Current Perspectives (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Human Umbilical Cord–Derived Stem Cells: Isolation, Characterization, Differentiation, and Application in Treating Diabetes
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Bhawna Chandravanshi, Ramesh R. Bhonde
New Scientific Approaches to Cancer Treatment: Can Medicinal Mushrooms Defeat the Curse of the Century?
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 1
Roumyana D. Petrova
Review of Bioactive Molecules Production, Biomass, and Basidiomata of Shiitake Culinary-Medicinal Mushrooms, Lentinus edodes (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 9
Damian López-Peña, Aldo Gutiérrez, Rigoberto Gaitán-Hernández, Martín Esqueda
Taking Ingredients as an Entry Point to Explore the Relationship between the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), and Diabetes Mellitus (Review)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 5
Fangxue Xu, Shiyuan Wang, Mengmeng Zheng, Chunchao Han, Hong Guo, Yujuan Li, Xiaowei Cui, Xiaozhi Xi, Hui Cao