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International Journal of Medicinal Mushrooms
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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024564
pages 905-913

A Primary Study of the Antioxidant, Hypoglycemic, Hypolipidemic, and Antitumor Activities of Ethanol Extract of Brown Slimecap Mushroom, Chroogomphus rutilus (Agaricomycetes)

Jinxiu Zhang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Xiaojing Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li Qiang Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Junxia Zhao
The Basic Medical College, Hebei Medical University, Shijiazhuang, People's Republic of China
Zhiguang Qi
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li-An Wang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China

ABSTRAKT

In vivo and in vitro treatments were carried out to investigate the effects of a 95% ethanol extract of Chroogomphus rutilus (CRE) on antioxidant, hypoglycemic, hypolipidemic, and antitumor properties. CRE showed potent radical scavenging activity against DPPH in vitro. It could increase antioxidant enzymatic activities (superoxide dismutase and glutathione peroxidase) and could reduce malondialdehyde content in vivo in mice in which aging was induced by D-galactose. CRE had hypoglycemic activity and could significantly inhibit α-glucosidase activity in vitro and decrease blood glucose concentration in vivo. CRE could decrease the serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and increase the high-density lipoprotein cholesterol level in diabetic mice. The MTT assay showed that CRE also had a certain inhibitory effect on the tumor cells. These results suggest that CRE may be beneficial for human health and could be useful for applications in medicine, the food industry, and agriculture.


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