Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i9.40
pages 793-806

Induction of Flavin-Containing Monooxygenase in Mice by Oral Administration of Phellinus baumii (Agaricomycetes) Extract

Batbayar Sainkhuu
Department of Life Science, University of Seoul, Seoul, Korea
Beom Su Park
Department of Life Science, University of Seoul, Seoul, Korea
Ha Won Kim
Department of Life Sciences, University of Seoul Dongdaemun-gu, Jennong-dong 90, Seoul 130-743, South Korea


Phellinus baumii is a yellow mushroom long used in alternative medicine in Korea and other central Asian countries. To identify genes affected by a single or 7-day oral administration of a water extract of Ph. Baumii, mouse liver tissue was analyzed using microarrays. The results showed that 8 and 23 genes were upregulated and 3 and 11 genes downregulated more than 3-fold by single and multiple oral administrations of 100 mg/kg PBE, respectively. Among the upregulated genes, the expression of 3 flavin-containing monooxygenase (Fmo) family genes, Fmo2−4, was upregulated in a concentration-dependent manner. The microarray analysis also showed that single and multiple administrations of PBE increased Fmo3 expression in the mouse liver by 5.1- and 17.6-fold, respectively. To validate the Fmo expression microarray data, polymerase chain reaction was used to confirm the induction of Fmo subclass genes. Mice were orally administered Ph. Baumii extract (PBE), Ph. Baumii water, or Ph. Baumii β-glucan fraction (PBG) for 7 days, and induction of the expression of the Fmo subclasses in the liver, lung, and kidney was investigated. Fmo2, Fmo3, and Fmo4 expression was induced by both PBE and PBG in the lung, liver, and kidney, respectively. However, no induction of Fmo1 and Fmo5 was detected. To investigate the metabolic acceleration of xenobiotic by PBE, carbendazim was orally administered to mice and its clearance from the blood analyzed. High-performance liquid chromatography analysis showed accelerated clearance of serum carbendazim by oral administration of PBE for 7 days, as evidenced by the reduced peak plasma concentration, time to reach the peak plasma concentration, and area under the curve values. Moreover, PBE increased the carbendazim clearance rate at the higher concentration. These data indicate that oral administration of PBE resulted in modulation of gene expression: PBE was responsible for the induction of Fmo2, Fmo3, and Fmo4 expression. PBE also accelerated the metabolic clearance of carbendazim in vivo and so could be applied to the detoxification of xenobiotics such as drugs, pesticides, and nicotine.

Articles with similar content:

Radiolabeling of Cisplatin and Its Biodistribution in an Experimental Model of Lung Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Chatterji Piyali, Kamal Rozy, Vijayta Dani Chadha
Histopathological, Enzymatic, and Molecular Alterations Induced By Cigarette Smoke Inhalation in the Pulmonary Tissue of Mice and Its Amelioration By Aqueous Azadirachta Indica Leaf Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Ashwani Koul, Sanjay Bharati, Neha Kapoor
Chemopreventive Potential of an Indian Medicinal Plant (Tinospora cordifolia) on Skin Carcinogenesis in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 3
Pradeep Kumar Goyal, Ranu Chaudhary, Swafiya Jahan
Short-Term Effects of Titanium Dioxide Nanofiber on the Renal Function of Male Sprague Dawley Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 2
Ji Wu, Ian Byrd, Bethany Bogan, Daniel A. Hunter, Wilson Yau, Leah K. Bartel, Worlanyo Eric Gato
Water-Soluble Polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) Alleviate the Dose-Limiting Toxicities of Irinotecan (CPT-11)
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 4
Xiaoxia Yang, Yihuai Gao, Zeping Hu, Shufeng Zhou, Xiao Chen