Erscheint 12 Ausgaben pro Jahr
ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Optimization of Solid State Culture Conditions for the Production of Adenosine, Cordycepin, and D-mannitol in Fruiting Bodies of Medicinal Caterpillar Fungus Cordyceps militaris (L.:Fr.) Link (Ascomycetes)
ABSTRAKT
In general, Cordyceps sinensis is much more popular than C. militaris, though both species contain quite similar bioactive ingredients and exhibit medicinal activities. Many bioactive ingredients have been isolated from C. militaris, such as adenosine, cordycepin, D-mannitol, and exopolysaccharides. C. militaris is claimed to have extensive pharmacological properties, such as: anti-inflammatory; anti-fatigue; anti-bacterial; anti-diabetic; improve lung, liver, and kidney functions; to be beneficial for treating cancer as well as male and female sexual dysfunctions. C. militaris is fast gaining momentum for its so-called health benefits, and it is often used as a substitute for C. sinensis. In view of the growing popularity of C. militaris, nowadays C. militaris cultivation for stroma is also done. There is a great diversity of compounds from different strains of Cordyceps and different artificially cultivated products. This study is to determine the optimum culture parameters integrated with substrate of choice to bring the indoor-cultivated C. militaris to a higher and more consistent level of quality. To achieve the above objective, the resultant products after growth were analyzed for adenosine, cordycepin, and D-mannitol using the high-performance liquid chromatography method. The optimum culture condition to produce a high level of adenosine is by using millet as solid substrate. It must be cultivated in the dark for the first 7 days and harvested on day 40. The optimum culture condition to produce a high level of cordycepin is by using soybean as solid substrate. It must be cultivated in the dark for the first 14 days and harvested on day 50. While a high level of D-mannitol is achieved with millet as the solid substrate. It must be kept in the dark for the first 7 days and harvested on day 50. The adenosine level decreased and cordycepin increased from day 40 of culture to day 50 generally.i
-
Bao Li, Li Yongxia, Wang Quanxin, Han Junjie, Yang Xiaoli, Li Heran, Wang Shaojuan, Wen Huaan, Li Shaojie, Liu Hongwei, Nutritive and bioactive components in rice fermented with the edible mushroomPleurotus eryngii, Mycology: An International Journal on Fungal Biology, 4, 2, 2013. Crossref
-
Cui Jian Dong, Biotechnological production and applications ofCordyceps militaris, a valued traditional Chinese medicine, Critical Reviews in Biotechnology, 35, 4, 2015. Crossref
-
Chou Shang-Min, Lai Wan-Jung, Hong Tzu-Wen, Lai Jui-Ya, Tsai Sheng-Hong, Chen Yen-Hsun, Yu Sz -Hsien, Kao Cheng-Hsiang, Chu Richard, Ding Shih-Torng, Li Tsai-Kun, Shen Tang-Long, Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells, Phytomedicine, 21, 12, 2014. Crossref
-
Chou Shang-Min, Lai Wan-Jung, Hong Tzuwen, Tsai Sheng-Hong, Chen Yen-Hsun, Kao Cheng-Hsiang, Chu Richard, Shen Tang-Long, Li Tsai-Kun, Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris, The American Journal of Chinese Medicine, 43, 05, 2015. Crossref
-
Jiang Keqing, Han Richou, Rhf1 gene is involved in the fruiting body production of Cordyceps militaris fungus, Journal of Industrial Microbiology and Biotechnology, 42, 8, 2015. Crossref
-
Lima Cristiane U.J.O., Gris Eliana F., Karnikowski Margô G.O., Antimicrobial properties of the mushroom Agaricus blazei – integrative review, Revista Brasileira de Farmacognosia, 26, 6, 2016. Crossref
-
Lo Hui-Chen, Hsieh Chienyan, Lin Fang-Yi, Hsu Tai-Hao, A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients, Journal of Traditional and Complementary Medicine, 3, 1, 2013. Crossref
-
TIAN XUEWEN, LI YUJIAN, SHEN YINYU, LI QIAOQIAO, WANG QINGLU, FENG LIANSHI, Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin, Oncology Letters, 10, 2, 2015. Crossref
-
Lin Qunying, Long Liangkun, Wu Liangliang, Zhang Fenglun, Wu Shuling, Zhang Weiming, Sun Xiaoming, Evaluation of different agricultural wastes for the production of fruiting bodies and bioactive compounds by medicinal mushroomCordyceps militaris, Journal of the Science of Food and Agriculture, 97, 10, 2017. Crossref
-
Park Jae Gwang, Son Young-Jin, Lee Tae Ho, Baek Nam Joon, Yoon Deok Hyo, Kim Tae Woong, Aravinthan Adithan, Hong Sungyoul, Kim Jong-Hoon, Sung Gi-Ho, Cho Jae Youl, Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model, Evidence-Based Complementary and Alternative Medicine, 2017, 2017. Crossref
-
Feng Yu-jie, Zhu Yun, Li Yong-mei, Li Jin, Sun Yan-fei, Shen Hai-tao, Wang Ai-ying, Lin Zhong-ping, Zhu Jian-bo, Effect of strain separated parts, solid-state substrates and light condition on yield and bioactive compounds ofCordyceps militarisfruiting bodies, CyTA - Journal of Food, 16, 1, 2018. Crossref
-
Luo Qing-Ying, Cao Hong-Fu, Liu Shu-Kun, Wu Min, Li Shan-Shan, Zhang Zhi-Qing, Chen An-Jun, Shen Guang-Hui, Wu He-Jun, Li Mei-Liang, Liu Xing-Yan, Jiang Yong, Bi Jun-Fei, He Zheng-You, Novel liquid fermentation medium of Cordyceps militaris and optimization of hydrothermal reflux extraction of cordycepin, Journal of Asian Natural Products Research, 22, 2, 2020. Crossref
-
Jiaojiao Zhang, Fen Wang, Kuanbo Liu, Qing Liu, Ying Yang, Caihong Dong, Heat and light stresses affect metabolite production in the fruit body of the medicinal mushroom Cordyceps militaris, Applied Microbiology and Biotechnology, 102, 10, 2018. Crossref
-
Kunhorm Phongsakorn, Chaicharoenaudomrung Nipha, Noisa Parinya, Enrichment of cordycepin for cosmeceutical applications: culture systems and strategies, Applied Microbiology and Biotechnology, 103, 4, 2019. Crossref
-
Yang Liyang, Li Guilan, Chai Zhi, Gong Qiang, Guo Jianquan, Synthesis of cordycepin: Current scenario and future perspectives, Fungal Genetics and Biology, 143, 2020. Crossref
-
Ren Wenqiang, Wang Chengyu, Zhao Ran, Li Honghua, Zhang Qinghua, Cai Di, Artificial cordyceps mycelium by submerged fermentation of Hirsutella sinensis HS 1201 using rice bran hydrolysate as substrate , Environmental Quality Management, 31, 1, 2021. Crossref
-
Thương Nguyễn Thị Liên, Danh Trịnh Diệp Phương, hiệp Nguyễn Văn, Nấm đông trùng hạ thảo Cordyceps militaris: Đặc điểm sinh học, giá trị dược liệu và các yếu tố ảnh hưởng đến quá trình nuôi trồng nấm, Can Tho University, Journal of Science, 44, 2016. Crossref
-
Singpoonga Natthapong, Rittiron Ronnarit, Seang-on Boonsong, Chaiprasart Peerasak, Bantadjan Yuranan, Determination of Adenosine and Cordycepin Concentrations in Cordyceps militaris Fruiting Bodies Using Near-Infrared Spectroscopy, ACS Omega, 5, 42, 2020. Crossref
-
Borde Mahesh, Singh Sanjay K., Prospects of Cordycepin and Polysaccharides Produced by Cordyceps, in Fungal diversity, ecology and control management, 2022. Crossref
-
Ha S.Y., Jung J.Y., Yang J.K., Optimization of a solid culture medium based on Monochamus alternatus for Cordyceps militaris fruiting body formation , Letters in Applied Microbiology, 74, 2, 2022. Crossref
-
Iamtham Siriluck, Kaewkam Adisak, Chanprame Sermsiri, Pan-utai Wanida, Effect of Spirulina biomass residue on yield and cordycepin and adenosine production of Cordyceps militaris culture, Bioresource Technology Reports, 17, 2022. Crossref
-
Chiu Ching-Peng, Hwang Tsong-Long, Chan You, El-Shazly Mohamed, Wu Tung-Ying, Lo I-Wen, Hsu Yu-Ming, Lai Kuei-Hung, Hou Ming-Feng, Yuan Shyng-Shiou, Chang Fang-Rong, Wu Yang-Chang, Research and development of Cordyceps in Taiwan, Food Science and Human Wellness, 5, 4, 2016. Crossref
-
Chang Szu-Hsing , Hsi Hsiao-Yang, Leu Jyh-Yih , Lee Tzong-Huei , Cereal-Based Solid-State Fermentation and Anti-Inflammatory Potential of Paecilomyces cicadae SH1 (Ascomycota) Isolated in China , International Journal of Medicinal Mushrooms, 24, 9, 2022. Crossref
-
Borworn Werapan, Pumin Nutaratat, Siriporn Ariyaphuttarat, Wai Prathumpai, Cordycepin production by the potential fungal strains Cordyceps militaris BCC 2819 and Cordyceps cicadae BCC 19788 in submerged culture during batch and Fed-batch fermentation, African Journal of Biotechnology, 21, 10, 2022. Crossref