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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
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Exploring the Medicinal Potential of the Fruit Bodies of Oyster Mushroom, Pleurotus ostreatus (Agaricomycetes), against Multidrug-Resistant Bacterial Isolates
ABSTRAKT
Bacterial resistance to present-generation antibiotics is increasing drastically, which has become a major public health concern. The present study focuses on demonstrating the antimicrobial potential of fruit bodies of the culinary/medicinal oyster mushroom Pleurotus ostreatus against clinical pathogens. Five bacterial isolates were collected from Sagar Hospital in Bangalore, India. The collected strains were grown on selective and differential media and antibiotic susceptibility testing was applied using 48 antibiotics by disc diffusion assay. The antibacterial efficiency of the mushroom extract against clinical pathogens, which were found to be multidrug resistant (MDR) to most of the tested antibiotics, was studied. The yield of cultivated mushrooms was evident at moist, cooler, and humid conditions. The clinical isolates of Staphylococcus aureus, Salmonella typhi, Acinetobacter sp., Proteus mirabilis, and Proteus spp. were found to be MDR to β-lactam, fluoroquinolones, sulfonamides, third- and fourth-generation cephalosporins, aminoglycosides, macrolides, tetracyclines, and carbapenems. The methanolic extracts of mushroom fruit bodies were found to be more effective than present-generation antibiotics against methicillin- and vancomycin- resistant S. aureus, S. typhi, Acinetobacter sp., and P. mirabilis at a concentration ranging from 50 to 100 µg/disc or 50 to 100 µL/well. The current study suggests that the methanolic extract of P. ostreatus can be used as a promising antibacterial agent against MDR bacterial pathogens.
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Ayman A. Elshayeb, Abdelazim A. Ahmed, Marmar A. El Siddig, Adil A. El Hussien, Potentiality of lytic bacteriophages and their virolysins in lysing multi-drug resistant Salmonella typhi, African Journal of Biotechnology, 16, 41, 2017. Crossref
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Li Huili, Tian Yang, Menolli Nelson, Ye Lei, Karunarathna Samantha C., Perez‐Moreno Jesus, Rahman Mohammad Mahmudur, Rashid Md Harunur, Phengsintham Pheng, Rizal Leela, Kasuya Taiga, Lim Young Woon, Dutta Arun Kumar, Khalid Abdul Nasir, Huyen Le Thanh, Balolong Marilen Parungao, Baruah Gautam, Madawala Sumedha, Thongklang Naritsada, Hyde Kevin D., Kirk Paul M., Xu Jianchu, Sheng Jun, Boa Eric, Mortimer Peter E., Reviewing the world's edible mushroom species: A new evidence‐based classification system, Comprehensive Reviews in Food Science and Food Safety, 20, 2, 2021. Crossref