Erscheint 12 Ausgaben pro Jahr
ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Immunomodulating Activities of Cultivated Maitake Medicinal Mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (Higher Basidiomycetes) on Peripheral Blood Mononuclear Cells
ABSTRAKT
Grifola frondosa is a culinary-medicinal mushroom that contains several physiologically active compounds, of which polysaccharides, specifically β-glucans, are known to possess immunomodulating properties. Its extracts are studied for application as adjuncts for chemotherapy, and experiments in animal models support the use of this mushroom for cancer treatment. The effect of extracts obtained from mushrooms cultivated on different substrates and their capacity of inducing the secretion of cytokines from human peripheral blood mononuclear cells were studied. The activity of extracts at concentrations 12.5, 100, and 200 μg/mL on induction of TNF-α, IFN-γ, and IL-12 was screened. Two extracts from substrates fortified with olive oil press cakes showed appreciable activity and induced the secretion of TNF-α, IL-12, and INF-γ. The extracts differed from the others in the amount of sugar, protein, and β-glucans, which can explain their higher activity. Present results show that different substrates and different source materials can reasonably modify the bioactivity of cultivated G. frondosa.
-
Klaus Anita, Kozarski Maja, Vunduk Jovana, Todorovic Nina, Jakovljevic Dragica, Zizak Zeljko, Pavlovic Vladimir, Levic Steva, Niksic Miomir, Van Griensven Leo J.L.D., Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa, Food Research International, 67, 2015. Crossref
-
Lemieszek Marta K., Nunes Fernando M., Rzeski Wojciech, Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon, Food & Function, 10, 9, 2019. Crossref
-
Braico Diego Maximo Aguilera, Gabriela Andrea Balogh, Molecular Mechanism Induced by Beta-Glucans from Maitake to Recover T Cell-Subpopulations during Immunosuppression, in An Introduction to Mushroom, 2020. Crossref