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International Journal of Medicinal Mushrooms
Impact-faktor: 1.423 5-jähriger Impact-Faktor: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i1.50
pages 45-47

Moderate Angiotensin I Converting Enzyme (ACE) Inhibitors from the Edible Mushroom Pleurotus citrinopileatus Singer (Agaricomycetideae)

Hiroyuki Suzuki
Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan
Masaaki Kiyoto
Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan
Naoki Nobuyama
Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan
Takaaki Hara
Hakuju Life Science Co., Ltd., 32-17 Oyamahigashi-cho, Itabashi-ku, Tokyo 173-0004, Japan
Yuzo Yagi
Hakuju Life Science Co., Ltd., 32-17 Oyamahigashi-cho, Itabashi-ku, Tokyo 173-0004, Japan
Iwao Togashi
Department of Material Chemistry, Asahikawa National College of Technology, Asahikawa 071-8142, Japan
Akira Harada
Chemical Biology Institute, Inc., 4-9-2-1Utsukushigaoka, Kiyota-ku, Sapporo 004-0814, Japan
Masakazu Aoyama
Laboratory of Bioresource Science, Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Kitami 090-8507, Japan

ABSTRAKT

The acetone extract of Pleurotus citrinopileatus showed a moderate inhibitory activity against the angiotensin I converting enzyme (ACE). The 50% inhibitory concentration (IC50) of the extract for ACE activity was 50.2 mg ml−1. D-mannitol was isolated as an active principle with a yield of 5.75 %. The IC50 value of the compound was 33.4 mg ml−1. D-arabitol and glycerol were also detected in the acetone extract. D-arabitol acted as an ACE inhibitor, whereas only limited activity was observed by the dose of glycerol.


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