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ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158
Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus
ABSTRAKT
Changes in electrophysiological characteristics and ongoing activity parameters of the isolated rat retinal ganglion cells were evaluated 3-4 weeks after streptozotocin injection (80 mg/kg). It has been revealed that electrophysiological characteristics significantly decreased. In particular, density of sodium current decreased by 35% (from -0.84 ± 0.14 nA/pF in control to -0.55 ± 0.08 nA/pF in streptozotocin-induced diabetes mellitus; potassium current decreased by 36% (0.87 ± 0.14 in diabetes versus 1.36 ± 0.16 nA/pF in control, and resting membrane potential decreased by 10% (-53 ± 1 mV in diabetes versus -59 ± 1 mV in control. The mean frequency of ongoing postsynaptic currents was reduced by 72% (2...5 ± 0.3 sec-1 in control and 0.7 ± 0.1 sec-1 in diabetes. The data suggest that pathological changes in the electrophysiological characteristics of the rat retinal ganglion cells appear at the early stage of experimentally-induced diabetes mellitus.