Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i2.20
pages 97-108

Paracrine Sonic Hedgehog Signaling Derived from Tumor Epithelial Cells: A Key Regulator in the Pancreatic Tumor Microenvironment

Xuqi Li
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University , Xi'an 710061, Shaanxi, China
Qingyong Ma
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
Wanxing Duan
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
Han Liu
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
Hongqin Xu
Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China
Erxi Wu
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105

ABSTRAKT

Activation of the hedgehog (Hh) signaling pathway is involved in embryo development and tumorigenesis. While normal pancreatic tissue exhibits little Hh pathway activity, patients with pancreatic adenocarcinoma have high levels of Hh pathway signaling in both the tumor epithelia and the surrounding stromal tissue. Hh ligands expressed by pancreatic cancers promote tumor growth indirectly by activating Hh signaling in the surrounding stroma. This paracrine activation of Hh signaling in the tumor microenvironment provides a more favorable environment for tumor cellular proliferation, metastasis, and resistance to therapy. Taken together, these findings are of valuable implications for the use of Hh pathway inhibitors currently in development and inhibition of the Hh pathway paracrine loop in pancreatic cancer.


Articles with similar content:

Molecular Mechanisms and Therapeutic Potential of miR-493 in Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 6
Lingwei Huang, Qing Wei, Lingli Huang, Ziwei Li
Inhibition of Snail-induced Epithelial-Mesenchymal Transition and Induction of the Tumor Metastasis Suppressor Gene Raf-1 Kinase Inhibitor Protein (RKIP) by DETANONOate
Forum on Immunopathological Diseases and Therapeutics, Vol.1, 2010, issue 3
Stavroula Baritaki, Benjamin Bonavida
Targeting PGE2 Signaling in Tumor Progression and Angiogenesis
Forum on Immunopathological Diseases and Therapeutics, Vol.5, 2014, issue 3-4
Federica Finetti, Erika Terzuoli, Marina Ziche, Lorenzo Bazzani, Sandra Donnini
Viral Infection and Cancer: The NF-κB/Snail/RKIP Loop Regulates Target Cell Sensitivity to Apoptosis by Cytotoxic Lymphocytes
Critical Reviews™ in Immunology, Vol.30, 2010, issue 1
Stavroula Baritaki, Benjamin Bonavida
p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 3-4
Jacques E. Nör, Christie Rodriguez-Ramirez