Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013978
pages 259-268

Roles of Protein N-Myristoylation and Translational Medicine Applications

Mengmeng Xu
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China
Longxiang Xie
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ecoenvironments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China
Zhaoxiao Yu
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China
Jianping Xie
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Three Gorges Eco-Environment and Bioresources, Eco-Environment Key Laboratory of the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest Uni

ABSTRAKT

Protein N-myristoylation is a ubiquitous cotranslational and posttranslational modification catalyzed by myristoyl CoA:protein N-myristoyltransferase (NMT), which attaches myristate, a rare 14-carbon saturated fatty acid, to an N-terminal glycine of some eukaryotic and virus proteins. This protein modification triggers dynamic protein−protein and protein−membrane interactions implicated in diverse physiological processes. This review summarizes the NMT catalytic mechanism and demyristoylation. Of special interest are the primary roles of N-myristoylated protein in signaling, protein targeting, tumorigenesis, apoptosis, virus assembly, and morphology change, as well as the regulation of N-myristoylation and NMT inhibitors.


Articles with similar content:

The VAV Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Xose R. Bustelo
Transcription Regulator Yin-Yang 1: From Silence to Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Weidong Zhu, Hermes Garban, Samuel Y. Olson
Vitamin D and MicroRNAs in Bone
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 3
Martin Hewison, John S. Adams, Thomas S. Lisse
Nuclear Receptors in Stem Cell Biology
Critical Reviews™ in Eukaryotic Gene Expression, Vol.16, 2006, issue 2
Yanhong Shi, Guoqiang Sun, Richard Stewart
Human Metallothionein Expression under Normal and Pathological Conditions: Mechanisms of Gene Regulation Based on In silico Promoter Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 4
Pieter De Bleser, Debby Laukens, Claude Cuvelier, Martine De Vos, Anouk Waeytens