Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Genome Instability in the Context of Chromatin Structure and Fragile Sites
ABSTRAKT
Genomes are exposed to various external stimuli that induce DNA damage in the form of single- or double-stranded DNA breaks. Fragile sites in the human genome are sensitive to genotoxic stress and, when not appropriately repaired, are responsible for chromosomal aberrations, including the gene amplifications observed in a variety of tumors. Moreover, when DNA lesions from different chromosomes are in close proximity and not repaired, the probability of chromosome translocations is greatly increased. These events can be induced by ionizing radiation that, in a majority of cells, induces a G2/M cell cycle arrest and is characterized by the repositioning of many tumor-related genes closer to the nuclear interior. On the basis of this knowledge, we review functional and structural aspects of chromosomal rearrangements and the DNA repair machinery.
-
Moskalev Alexey A., Shaposhnikov Mikhail V., Plyusnina Ekaterina N., Zhavoronkov Alex, Budovsky Arie, Yanai Hagai, Fraifeld Vadim E., The role of DNA damage and repair in aging through the prism of Koch-like criteria, Ageing Research Reviews, 12, 2, 2013. Crossref
-
Ma Ke, Qiu Li, Mrasek Kristin, Zhang Jun, Liehr Thomas, Quintana Luciana Gonçalves, Li Zheng, Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis, International Journal of Molecular Sciences, 13, 12, 2012. Crossref
-
Holt Ian J., Jacobs Howard T., Unique features of DNA replication in mitochondria: A functional and evolutionary perspective, BioEssays, 36, 11, 2014. Crossref
-
Bártová Eva, Malyšková Barbora, Komůrková Denisa, Legartová Soňa, Suchánková Jana, Krejčí Jana, Kozubek Stanislav, Function of heterochromatin protein 1 during DNA repair, Protoplasma, 254, 3, 2017. Crossref
-
Foltánková Veronika, Legartová Soňa, Kozubek Stanislav, Hofer Michal, Bártová Eva, DNA-damage response in chromatin of ribosomal genes and the surrounding genome, Gene, 522, 2, 2013. Crossref