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Critical Reviews™ in Eukaryotic Gene Expression

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Genome Instability in the Context of Chromatin Structure and Fragile Sites

Volumen 20, Ausgabe 3, 2010, pp. 181-194
DOI: 10.1615/CritRevEukarGeneExpr.v20.i3.10
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ABSTRAKT

Genomes are exposed to various external stimuli that induce DNA damage in the form of single- or double-stranded DNA breaks. Fragile sites in the human genome are sensitive to genotoxic stress and, when not appropriately repaired, are responsible for chromosomal aberrations, including the gene amplifications observed in a variety of tumors. Moreover, when DNA lesions from different chromosomes are in close proximity and not repaired, the probability of chromosome translocations is greatly increased. These events can be induced by ionizing radiation that, in a majority of cells, induces a G2/M cell cycle arrest and is characterized by the repositioning of many tumor-related genes closer to the nuclear interior. On the basis of this knowledge, we review functional and structural aspects of chromosomal rearrangements and the DNA repair machinery.

REFERENZIERT VON
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