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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.10
pages 303-311

Review on Regulation of Inwardly Rectifying Potassium Channels

Junshuai Wang
Tongji Hospital of Wuhan
Yuancheng Huang
Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Qin Ning
Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology


An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or G-proteins. Other factors like polyamines, kinases, pH, and Na+ ions act cooperatively to modulate Kir channels. Different types and specific distributions of KIR channels determine the diversity of regulatory mechanisms. This review provides insight into Kir channel regulation.

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