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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.40
pages 141-148

miRNA*: A Passenger Stranded in RNA-Induced Silencing Complex?

S. M. Mah
Terry Fox Laboratory, BC Cancer Agency
C. Buske
Institute of Experimental Cancer Research, Comprehensive Cancer Centre, University Hospital of Ulm
R. K. Humphries
Terry Fox Laboratory, BC Cancer Agency
Florian Kuchenbauer
Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada; Department of Internal Medicine III, Institute of Experimental Cancer Research, Comprehensive Cancer Centre, University Hospital of Ulm

ABSTRAKT

Processing of the pre-microRNA (pre-miRNA) through Dicer1 generates a miRNA duplex, consisting of a miRNA and miRNA* strand (also termed guide strand and passenger strand, respectively). Despite the general consensus that miRNA*s have no regulatory activity, recent publications have provided evidence that the abundance, possible function, and physiological relevance of miRNA*s have been underestimated. This review provides an account of our current understanding of miRNA* origination and activity, mounting evidence for their unique functions and regulatory mechanisms, and examples of specific miRNA*s from the literature.

SCHLÜSSELWÖRTER: microRNA, passenger strand, RISC

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