Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v8.i2.60
pages 203-224

The Biology of Prothrombin

Sandra J. F. Degen
Department of Pediatrics, Division of Developmental Biology, Children's Hospital Research Foundation and the University of Cincinnati, Cincinnati, Ohio 45229
William Y. Sun
Department of Pediatrics, Division of Developmental Biology, Children's Hospital Research Foundation and the University of Cincinnati, Cincinnati, Ohio 45229

ABSTRAKT

Prothrombin and thrombin are involved in diverse biological functions. The structure of prothrombin has been studied extensively and its cDNA has been cloned from several species. The tissue-specific expression of this protein has been studied, as well as the developmental expression pattern. The structure of the human gene coding for prothrombin has been determined, and gene regulation studies have been performed that indicate that HNF-1 might be responsible for the liver-specific expression of this protein. Other regulatory elements have been identified. In order to further study the biological properties of prothrombin, prothrombin-deficient mice have been generated using gene targeting technology. Prothrombin deficiency in mice results in partial embryonic lethality. The mice that survive to birth die from bleeding events. The embryonic lethality occurs between embryonic days 9.5 and 11.5 and appears to be due to the loss of integrity of the vasculature due to a failure in blood coagulation. These results indicate that prothrombin plays not only a key role in hemostasis but suggests that it may be important for mouse development.


Articles with similar content:

Oncogene- and Tumor-Suppressor Gene-Related Proteins in Plants and Fungi
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Peter Loidl, Adele Loidl
Factors Determining Airway Caliber in Asthma
Critical Reviews™ in Biomedical Engineering, Vol.41, 2013, issue 6
Brian C. Harvey, Kenneth R. Lutchen
Developmental Regulation of Elastin Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Steven Perrin , Judith Ann Foster
The Role of Intermediate Filament Proteins in the Development of Neurological Disease
Critical Reviews™ in Neurobiology, Vol.19, 2007, issue 1
Matthew W. Kemp, Kay E. Davies
How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Jillian P. Rhoads, Amy S. Major