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Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i1.50
8 pages

Specification of Chromatin Domains and Regulation of Replication and Transcription During Development

Yegor S. Vassetzky
CNRS UMR-8126, Institut Gustave Roussy, Villejuif 94805, France
Jean-Marc Lemaitre
Institut de Genetique Humaine, CNRS UPR1142, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
Marcel Mechali
Institut de Genetique Humaine, CNRS UPR1142, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France

ABSTRAKT

It is becoming increasingly clear that transcription control is carried out at several interconnecting levels. Besides nucleosomal organization and interaction between transcription factors and gene promoters and other regulatory elements, long-range organization of chromatin in loops or domains seems to play a role in transcriptional regulation. A similar organization is likely to be crucial in the control of the timing and selection of origins of DNA replication. This review considers the implications of domain organization of eukaryotic genome in developmental control of transcription and replication.