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ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Specification of Chromatin Domains and Regulation of Replication and Transcription During Development
ABSTRAKT
It is becoming increasingly clear that transcription control is carried out at several interconnecting levels. Besides nucleosomal organization and interaction between transcription factors and gene promoters and other regulatory elements, long-range organization of chromatin in loops or domains seems to play a role in transcriptional regulation. A similar organization is likely to be crucial in the control of the timing and selection of origins of DNA replication. This review considers the implications of domain organization of eukaryotic genome in developmental control of transcription and replication.
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