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Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v10.i1.90
18 pages

Transcriptional Augmentation: Modulation of Gene Expression by Scaffold/Matrix-Attached Regions (S/MAR Elements)

Jurgen Bode
GBF, National Center for Biotechnologioal Research, D-38124 Braunschweig, Mascheroder Weg 1
Craig Benham
Department of Biomathematical Sciences, Box 1023, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029
Angela Knopp
GBF, National Center for Biotechnologioal Research, D-38124 Braunschweig, Mascheroder Weg 1
Christian Mielke
University of Aarhus, Dept. of Molecular and Structural Biology, C.F. Mollers Alle 131, DK-8000 Aarhus C, Denmark

ABSTRAKT

For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.