Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 1.841 5-jähriger Impact-Faktor: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i1.10
pages 1-9

Determinants of Pathologic Mineralization

Thorsten Kirsch
Musculoskeletal Research Laboratories, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA

ABSTRAKT

Physiologic mineralization is necessary for the formation of skeletal tissues and for their appropriate functions during adulthood. Mineralization has to be controlled and restricted to specific regions. If the mineralization process occurs in regions that normally do not mineralize, there can be severe consequences (pathologic or ectopic mineralization). Recent findings have indicated that physiologic and pathologic mineralization events are initiated by matrix vesicles, membrane-enclosed particles released from the plasma membranes of mineralization-competent cells. The understanding of how these vesicles are released from the plasma membrane and initiate the mineralization process may provide novel therapeutic strategies to prevent pathologic mineralization. In addition, other regulators (activators and inhibitors) of physiologic mineralization have been identified and characterized, and there is evidence that the same factors also contribute to the regulation of pathologic mineralization. Finally, programmed cell death (apoptosis) may be a contributor to physiologic mineralization and if occurring after tissue injury may induce pathologic mineralization and mineralization-related differentiation events in the injured and surrounding areas. This review describes how the understanding of mechanisms and factors regulating physiologic mineralization can be used to develop new therapeutic strategies to prevent pathologic or ectopic mineralization events.


Articles with similar content:

DLK1-MEG3 Imprinted Domain MicroRNAs in Cancer Biology
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 1
George Vartholomatos, Evangelos Voulgaris, Leonidas Benetatos
Exosomes, Ectosomes and the Two Together. Physiology and Pathology
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Jacopo Meldolesi
Lymphocyte Calcium Signaling Involves Dihydropyridine-Sensitive L-Type Calcium Channels: Facts and Controversies
Critical Reviews™ in Immunology, Vol.24, 2004, issue 6
Marc Moreau, Magali Savignac, Philippe Lory, Jean-Charles Guery, Catherine Leclerc, Lucette Pelletier, Bruno Gomes
Cancer and Cancer Stem Cells: New Molecular Perspectives
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Onur Sahin, Gokce Ceren Kuscu, Gulperi Oktem, Elif Tunc, Funda Cagirir Dindaroglu, Cevik Gurel, Ismet Hortu, Gizem Inetas, Aylin Buhur
Ras Suppressor-1 (RSU-1) in Cancer Cell Metastasis: Friend or Foe?
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 3-4
Vasiliki Gkretsi, Lefteris C. Zacharia, Triantafyllos Stylianopoulos