Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Eukaryotic Gene Expression
Impact-faktor: 2.156 5-jähriger Impact-Faktor: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i1.30
pages 35-45

The ROS-NOX Connection in Cancer and Angiogenesis

Christophe Blanchetot
Department of Cell Architecture and Dynamics, Institute of Biomembranes, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
Johannes Boonstra
Department of Cell Architecture and Dynamics, Institute of Biomembranes, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands

ABSTRAKT

Initially viewed as dangerous byproducts of aerobic life, reactive oxygen species (ROS) nowadays appear to be essential secondary messengers of many signaling cascades and cellular functions. The establishment of ROS as important signaling molecules has been confirmed by the existence of specialized ROS producing complexes expressed in nonphagocytic cells, the NADPH oxidase complex (NOX). Because of the diversity of their proteic targets (besides lipids and DNA), ROS have multiple and sometimes contradictory functions. In the present review, we focus on several different signaling pathways influenced by ROS and NOX in tumorigenesis, focusing on proliferation and angiogenesis. We review the ROS targets regulating proliferation, including cellular signaling (phosphatases, AP1, and nuclear factor−kappa B [NF−κB]) and cell cycle targets (CDC25, cyclin D, and forkhead proteins), and the role of NOX during proliferation. Finally, we review the direct and indirect involvement of ROS and NOX in (tumor) angiogenesis through the regulation of different biologic systems such as vascular endothelial growth factor, angiotensin II, hypoxia−inducible factor, AP1, and inflammation.


Articles with similar content:

Type 2 Diabetes and Cancer: The Nitric Oxide Connection
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 3
Asghar Ghasemi, Khosrow Kashfi, Parvin Mirmiran, Zahra Bahadoran
Integrin Control of Tumor Invasion
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 4
Dara S. Missan , Michael DiPersio
Mechanism of Nitric Oxide Production in Macrophages Treated with Medicinal Mushroom Extracts (Review)
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 1
Mian Huang, Xiaodeng Mei, Song Zhang
Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 5-6
Erika Terzuoli, Marina Ziche, Lorenzo Bazzani, Sandra Donnini
A Role for Nitric Oxide and for Nitric Oxide Synthases in Tumor Biology
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Heloisa Rosa, Adriana Karla C.A. Reis, Graciele A. de Oliveira, Hugo P. Monteiro, Arnold Stern