Abo Bibliothek: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

mTOR Signaling in Cancer Cell Motility and Tumor Metastasis

Volumen 20, Ausgabe 1, 2010, pp. 1-16
DOI: 10.1615/CritRevEukarGeneExpr.v20.i1.10
Get accessGet access

ABSTRAKT

Tumor cell migration is a key step in the formation of cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serinethreonine kinase, has been intensely studied for over a decade as a central regulator of cell growth, proliferation, differentiation, and survival. Recent data have shown that mTOR also plays a critical role in the regulation of tumor cell motility and cancer metastasis. Here, we briefly review recent advances regarding mTOR signaling in tumor cell motility. We also discuss recent findings about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell motility in vitro and metastasis in vivo.

SCHLÜSSELWÖRTER: mTOR, rapamycin, S6K1, Akt, cell motility, metastasis
REFERENZIERT VON
  1. Yuan Yuan, Xue Xue, Guo Ruo‐Bing, Sun Xiu‐Lan, Hu Gang, Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS‐dependent AMPK‐TSC‐mTOR Signaling Pathway, CNS Neuroscience & Therapeutics, 18, 7, 2012. Crossref

  2. Giraud Andrew S, Gastric mucosal healing: The role of the mTor pathway, Journal of Gastroenterology and Hepatology, 27, 9, 2012. Crossref

  3. Aslan Joseph E., McCarty Owen J.T., Regulation of the mTOR-Rac1 axis in platelet function, Small GTPases, 3, 1, 2012. Crossref

  4. Zhu Xingmei, Wu Lin, Qiao Hongyu, Han Tenglong, Chen Suning, Liu Xueying, Jiang Ru, Wei Yifang, Feng Dayun, Zhang Yuan, Ma Yongzheng, Zhang Shengyong, Zhang Jian, Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinib, Journal of Cellular Biochemistry, 114, 12, 2013. Crossref

  5. Han Tianyu, Kang De, Ji Daokun, Wang Xiaoyu, Zhan Weihua, Fu Minggui, Xin Hong-Bo, Wang Jian-Bin, How does cancer cell metabolism affect tumor migration and invasion?, Cell Adhesion & Migration, 7, 5, 2013. Crossref

  6. Zaytseva Yekaterina Y., Valentino Joseph D., Gulhati Pat, Mark Evers B., mTOR inhibitors in cancer therapy, Cancer Letters, 319, 1, 2012. Crossref

  7. Fan Yi-ling, Chen Lei, Wang Ji, Yao Qing, Wan Jie-qing, Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway, FEBS Letters, 587, 24, 2013. Crossref

  8. Zhang Huiyuan, Dou Jun, Yu Yang, Zhao Yanling, Fan Yihui, Cheng Jin, Xu Xin, Liu Wei, Guan Shan, Chen Zhenghu, shi Yan, Patel Roma, Vasudevan Sanjeev A., Zage Peter E., Zhang Hong, Nuchtern Jed G., Kim Eugene S., Fu Songbin, Yang Jianhua, mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling, Apoptosis, 20, 1, 2015. Crossref

  9. Bera Amit, Das Falguni, Ghosh-Choudhury Nandini, Kasinath Balakuntalam S., Abboud Hanna E., Choudhury Goutam Ghosh, microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion, Experimental Cell Research, 328, 1, 2014. Crossref

  10. Nagaraju Ganji Purnachandra, Long Tua-Elisabeth, Park Wungki, Landry Jerome C., Taliaferro-Smith LaTonia, Farris Alton B., Diaz Roberto, El-Rayes Bassel F., Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer, Molecular Carcinogenesis, 54, 10, 2015. Crossref

  11. Mu Xiaodong, Isaac Christian, Schott Trevor, Huard Johnny, Weiss Kurt, Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells, Sarcoma, 2013, 2013. Crossref

  12. Showkat Mehvish, Beigh Mushtaq A., Andrabi Khurshid I., mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions, Molecular Biology International, 2014, 2014. Crossref

  13. Gargalionis Antonios N., Korkolopoulou Penelope, Farmaki Elena, Piperi Christina, Dalagiorgou Georgia, Adamopoulos Christos, Levidou Georgia, Saetta Angelica, Fragkou Paraskevi, Tsioli Panagiota, Kiaris Hippokratis, Zizi-Serbetzoglou Adamantia, Karavokyros Ioannis, Papavassiliou Kostas A., Tsavaris Nikolaos, Patsouris Efstratios, Basdra Efthimia K., Papavassiliou Athanasios G., Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer, International Journal of Cancer, 136, 7, 2015. Crossref

  14. Wang Yunliang, Wang Yutong, Li Jinfeng, Zhang Yuzhen, Yin Honglei, Han Bing, CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling, Cancer Letters, 367, 2, 2015. Crossref

  15. Poglitsch M., Weichhart T., Hecking M., Werzowa J., Katholnig K., Antlanger M., Krmpotic A., Jonjic S., Hörl W. H., Zlabinger G. J., Puchhammer E., Säemann M. D., CMV Late Phase-Induced mTOR Activation Is Essential for Efficient Virus Replication in Polarized Human Macrophages, American Journal of Transplantation, 12, 6, 2012. Crossref

  16. Aslan Joseph E., Tormoen Garth W., Loren Cassandra P., Pang Jiaqing, McCarty Owen J. T., S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation, Blood, 118, 11, 2011. Crossref

  17. Bensimon Ariel, Aebersold Ruedi, Shiloh Yosef, Beyond ATM: The protein kinase landscape of the DNA damage response, FEBS Letters, 585, 11, 2011. Crossref

  18. Rangwala S., Tsai K.Y., Roles of the immune system in skin cancer, British Journal of Dermatology, 165, 5, 2011. Crossref

  19. Rahman Hazir, Qasim Muhammad, Oellerich Michael, Asif Abdul, Crosstalk between Edc4 and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in mRNA Decapping, International Journal of Molecular Sciences, 15, 12, 2014. Crossref

  20. Dey Nirmalya, Das Falguni, Ghosh-Choudhury Nandini, Mandal Chandi Charan, Parekh Dipen J., Block Karen, Kasinath Balakuntalam S., Abboud Hanna E., Choudhury Goutam Ghosh, Pal Soumitro, microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion, PLoS ONE, 7, 6, 2012. Crossref

  21. Matsuoka Tasuku, Yashiro Masakazu, The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma, Cancers, 6, 3, 2014. Crossref

  22. Celebi-Birand Ergul Dilan, Karoglu Elif Tugce, Doldur-Balli Fusun, Adams Michelle M., Mammalian Target of Rapamycin (mTOR), Aging, Neuroscience, and Their Association with Aging-Related Diseases, in Molecules to Medicine with mTOR, 2016. Crossref

  23. Weissmann Robert, Kacprowski Tim, Peper Michel, Esche Jennifer, Jensen Lars R., van Diepen Laura, Port Matthias, Kuss Andreas W., Scherthan Harry, Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts, Health Physics, 111, 2, 2016. Crossref

  24. Niu Pei-Guang, Zhang Yu-Xuan, Shi Dao-Hua, Liu Ying, Chen Yao-Yao, Deng Jie, Zhang Zhiqian, Cardamonin Inhibits Metastasis of Lewis Lung Carcinoma Cells by Decreasing mTOR Activity, PLOS ONE, 10, 5, 2015. Crossref

  25. Lee Ju-Hee, Son Young Hoon, Kwon Young-Won, Park Sung Yun, Koo Byung-Soo, Jung Seung Hyun, Anticancer Effects of a Korean Herbal Medicine Formula (H9) via AMPK and HER2-PI3K/Akt Signaling in Breast Cancer Cells, Phytotherapy Research, 31, 11, 2017. Crossref

  26. CHESOR MUSLEEHA, ROYTRAKUL SITTIRUK, GRAIDIST POTCHANAPOND, KANOKWIROON KANYANATT, Proteomics analysis of siRNA-mediated silencing of Wilms’ tumor 1 in the MDA-MB-468 breast cancer cell line, Oncology Reports, 31, 4, 2014. Crossref

  27. Krause Gabriele Catyana, Lima Kelly Goulart, Dias Henrique Bregolin, da Silva Elisa Feller Gonçalves, Haute Gabriela Viegas, Basso Bruno Souza, Gassen Rodrigo Benedetti, Marczak Elisa Simon, Nunes Rafaela Sole Bach, de Oliveira Jarbas Rodrigues, Liraglutide, a glucagon-like peptide-1 analog, induce autophagy and senescence in HepG2 cells, European Journal of Pharmacology, 809, 2017. Crossref

  28. Spangle Jennifer M., Munger Karl, Roman Ann, The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species, PLoS Pathogens, 9, 3, 2013. Crossref

  29. Abalsamo Laura, Spadaro Francesca, Bozzuto Giuseppina, Paris Luisa, Cecchetti Serena, Lugini Luana, Iorio Egidio, Molinari Agnese, Ramoni Carlo, Podo Franca, Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells, Breast Cancer Research, 14, 2, 2012. Crossref

  30. Ci Yingqian, Qiao Jinping, Han Mei, Molecular Mechanisms and Metabolomics of Natural Polyphenols Interfering with Breast Cancer Metastasis, Molecules, 21, 12, 2016. Crossref

  31. Rivera Rivera Amilcar, Castillo-Pichardo Linette, Gerena Yamil, Dharmawardhane Suranganie, Tan Ming, Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade, PLOS ONE, 11, 6, 2016. Crossref

  32. Bianchi Sara, Giovannini Luca, Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators, Nutrition and Cancer, 70, 3, 2018. Crossref

  33. Galigniana Mario D., HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease, in Heat Shock Protein 90 in Human Diseases and Disorders, 19, 2019. Crossref

  34. Fabbri Alessia, Travaglione Sara, Rosadi Francesca, Ballan Giulia, Maroccia Zaira, Giambenedetti Massimo, Guidotti Marco, Ødum Niels, Krejsgaard Thorbjørn, Fiorentini Carla, The Escherichia coli protein toxin cytotoxic necrotizing factor 1 induces epithelial mesenchymal transition , Cellular Microbiology, 22, 2, 2020. Crossref

  35. Fonseka Pamali, Liem Michael, Ozcitti Cemil, Adda Christopher G., Ang Ching‐Seng, Mathivanan Suresh, Exosomes from N‐Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non‐N‐Myc amplified cells: implications of intra‐tumour heterogeneity, Journal of Extracellular Vesicles, 8, 1, 2019. Crossref

  36. Ayuk Sandra M., Abrahamse Heidi, mTOR Signaling Pathway in Cancer Targets Photodynamic Therapy In Vitro, Cells, 8, 5, 2019. Crossref

  37. Alwine James C., DNA Viruses and Cancer: Taking a Broader Look, in Cancer Associated Viruses, 2012. Crossref

  38. Zhuravskaya A. Yu., Komelkov A. V., Tchevkina E. M., SMALL GTPASE ARF6 ACTIVATES mTORCl-DEPENDENT SIGNALING PATHWAY AND STIMULATES GLIOBLASTOMA CELL GROWTH, Russian Journal of Biotherapy, 14, 2, 2015. Crossref

  39. Wu Rui, Yu Wenyan, Yao Chuansheng, Liang Zhongxing, Yoon Younghyoun, Xie Yuanyuan, Shim Hyunsuk, Bai Renren, Amide-sulfamide modulators as effective anti-tumor metastatic agents targeting CXCR4/CXCL12 axis, European Journal of Medicinal Chemistry, 185, 2020. Crossref

  40. Coppock Joseph D., Vermeer Paola D., Vermeer Daniel W., Lee Kimberly M., Miskimins W. Keith, Spanos William C., Lee John H., mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC, Oncotarget, 7, 17, 2016. Crossref

  41. Shi Jia, Dong Bo, Cao Jiachao, Mao Yumin, Guan Wei, Peng Ya, Wang Suinuan, Long non-coding RNA in glioma: signaling pathways, Oncotarget, 8, 16, 2017. Crossref

  42. Guerra F, Quintana S, Giustina S, Mendeluk G, Jufe L, Avagnina MA, Díaz LB, Palaoro LA, Investigation of EGFR/pi3k/Akt signaling pathway in seminomas, Biotechnic & Histochemistry, 96, 2, 2021. Crossref

  43. Yan Wei , Li Shawn , Gao Hongyu , Yang Wei , Identification of B‑cell translocation gene 1‑controlled gene networks in diffuse large B‑cell lymphoma: A study based on bioinformatics analysis, Oncology Letters, 2019. Crossref

  44. Schrom Kory P., Kim InYoung, Baron Elma D., The Immune System and Pathogenesis of Melanoma and Non-melanoma Skin Cancer, in Sunlight, Vitamin D and Skin Cancer, 1268, 2020. Crossref

  45. Belayneh Rebekah, Weiss Kurt, The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets, in Current Advances in the Science of Osteosarcoma, 1258, 2020. Crossref

  46. Messeha Samia S., Zarmouh Najla O., Soliman Karam F. A., Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer, Nutrients, 13, 5, 2021. Crossref

  47. Hua Yingqi, Qiu Yunping, Zhao Aihua, Wang Xiaoyan, Chen Tianlu, Zhang Zhiyu, Chi Yi, Li Quan, Sun Wei, Li Guodong, Cai Zhengdong, Zhou Zhanxiang, Jia Wei, Dynamic Metabolic Transformation in Tumor Invasion and Metastasis in Mice with LM-8 Osteosarcoma Cell Transplantation, Journal of Proteome Research, 10, 8, 2011. Crossref

  48. Ghosh Paramita, Alam Neyaz, Mandal Shyamsundar, Mustafi Saunak Mitra, Murmu Nabendu, Association of mTOR pathway with risk of gastric cancer in male smoker with potential prognostic significance, Molecular Biology Reports, 47, 10, 2020. Crossref

  49. Li Zhiyu, Li Chenyuan, Wu Qi, Tu Yi, Wang Changhua, Yu Xin, Li Bei, Wang Zhong, Sun Si, Sun Shengrong, MEDAG enhances breast cancer progression and reduces epirubicin sensitivity through the AKT/AMPK/mTOR pathway, Cell Death & Disease, 12, 1, 2021. Crossref

  50. Sui Li, Zhang Rui-Hong, Zhang Ping, Yun Ke-Li, Zhang Hong-Cai, Liu Li, Hu Ming-Xu, Lead toxicity induces autophagy to protect against cell death through mTORC1 pathway in cardiofibroblasts, Bioscience Reports, 35, 2, 2015. Crossref

  51. Li B., Pang S., Dou J., Zhou C., Shen B., Zhou Y., The inhibitory effect of LINC00261 upregulation on the pancreatic cancer EMT process is mediated by KLF13 via the mTOR signaling pathway, Clinical and Translational Oncology, 24, 6, 2022. Crossref

  52. Liu Ying, Qi Cuiling, Zheng Lingyun, Li Jiangchao, Wang Lijing, Yang Yongxia, 1H-NMR based metabolic study of MMTV-PyMT mice along with pathological progress to screen biomarkers for the early diagnosis of breast cancer, Molecular Omics, 18, 2, 2022. Crossref

  53. Zheng Qingyuan, Zhang Qiyao, Yu Xiao, He Yuting, Guo Wenzhi, FENDRR: A pivotal, cancer-related, long non-coding RNA, Biomedicine & Pharmacotherapy, 137, 2021. Crossref

  54. Xu Chuanliang, Zeng Qinsong, Xu Weidong, Jiao Li, Chen Yanqiong, Zhang Zhensheng, Wu Chengyao, Jin Taile, Pan Anyin, Wei Rongchao, Yang Bo, Sun Yinghao, miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR, Molecular Cancer Therapeutics, 12, 2, 2013. Crossref

  55. Chen Guang, Chen Si-Meng, Wang Xiang, Ding Xiao-Fei, Ding Jian, Meng Ling-Hua, Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells, Journal of Biological Chemistry, 287, 15, 2012. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain