Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Strategies for Regeneration of Heart Muscle
ABSTRAKT
Regenerative medicine has emerged to the forefront of cardiac research, marrying discoveries in both basic science and engineering to develop viable therapeutic approaches for treating the diseased heart. Signifi cant advancements in gene therapy, stem cell biology, and cardiomyoplasty provide new optimism for regenerating damaged myocardium. Exciting new strategies for endogenous and exogenous regeneration have been proposed. However, questions remain as to whether these approaches can provide enough new myocyte mass to sufficiently restore mechanical function to the heart. In this article, we consider the mechanisms of endogenous cardiomyocyte regeneration and exogenous cell differentiation (with respect to myoblasts, stem cells, and induced pluripotent cells being researched for cell therapies). We begin by reviewing some of the cues that are being harnessed in strategies of gene/cell therapy for regenerating myocardium. We also consider some of the technical challenges that remain in determining new myocyte generation, tracking delivered cells in vivo, and correlating new myocyte contractility with cardiac function. Strategies for regenerating the heart are being realized as both animal and clinical trials suggest that these new approaches provide short-term improvement of cardiac function. However, a more complete understanding of the underlying mechanisms and applications is necessary to sustain longer-term therapeutic success.
-
Georgiadis Vassilis, Knight Richard A., Jayasinghe Suwan N., Stephanou Anastasis, Cardiac tissue engineering: renewing the arsenal for the battle against heart disease, Integr. Biol., 6, 2, 2014. Crossref
-
Ting Sherwin, Liew Seaw Jia, Japson Francis, Shang Fuchun, Chong Wee Keat, Reuveny Shaul, Tham Jo Yew, Li Xiang, Oh Steve, Time‐resolved video analysis and management system for monitoring cardiomyocyte differentiation processes and toxicology assays, Biotechnology Journal, 9, 5, 2014. Crossref
-
Frohlich Edward D., Susic Dinko, Pressure Overload, Heart Failure Clinics, 8, 1, 2012. Crossref
-
Tan Jun Jie, Guyette Jacques P., Miki Kenji, Xiao Ling, Kaur Gurbani, Wu Tong, Zhu Liye, Hansen Katrina J., Ling King-Hwa, Milan David J., Ott Harald C., Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro, Nature Communications, 12, 1, 2021. Crossref
-
Azene Nicole, Fu Yingli, Maurer Jeremy, Kraitchman Dara L, Tracking of stem cells in vivo for cardiovascular applications, Journal of Cardiovascular Magnetic Resonance, 16, 1, 2014. Crossref