Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Druckformat: 0278-940X
ISSN Online: 1943-619X

Volumen 48, 2020 Volumen 47, 2019 Volumen 46, 2018 Volumen 45, 2017 Volumen 44, 2016 Volumen 43, 2015 Volumen 42, 2014 Volumen 41, 2013 Volumen 40, 2012 Volumen 39, 2011 Volumen 38, 2010 Volumen 37, 2009 Volumen 36, 2008 Volumen 35, 2007 Volumen 34, 2006 Volumen 33, 2005 Volumen 32, 2004 Volumen 31, 2003 Volumen 30, 2002 Volumen 29, 2001 Volumen 28, 2000 Volumen 27, 1999 Volumen 26, 1998 Volumen 25, 1997 Volumen 24, 1996 Volumen 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2019026426
pages 217-234

An Experimental Platform for Characterizing Cancer Biomarkers with Capabilities in Noninvasive and Continuous Screening

Mackenzie M. Honikel
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona
Jeffrey T. La Belle
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona


Early detection is crucial to the proper and effective treatment of two metastatic cancers, prostate cancer and small cell lung cancer. Currently, preventative screenings for these conditions are restricted to high-risk populations and extremely expensive. The discovery of clinically indicative biomarkers has been revolutionary in advancing screening and diagnostic capabilities. Prostate-specific antigen (PSA), an extracellular secreted protein of the prostate gland, and neuron-specific enolase (NSE), an enzyme of neuronal origin, have reported reputable specificity for prostate cancer and small cell lung cancer (SCLC). Current efforts are underway to develop a rapid, label-free means of measuring both PSA and NSE levels in a clinical environment for early screening applications of highly metastatic cancers. Electrochemical impedance spectroscopy (EIS) and impedance time (Z-t) are rapid, sensitive electrochemical techniques previously validated in the detection of several clinically relevant biomarkers, including cardiovascular disease and diabetes mellitus. Herein, we determine the optimal frequencies of PSA (81.38 Hz) and NSE (14.36 Hz) using EIS that are robust across analytical platforms and in the presence of potentially interfering species. The reported empirical evidence supports the prevalence of electrostatic interactions in electrochemical systems and provides alternative theoretical support of previous findings. Finally, Z-t was implemented for its utility in continuous monitoring applications and to lay the foundation for future improvements to continuous sensor platforms.

Articles with similar content:

Multi-Biomarker Detection Following Traumatic Brain Injury
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 3
Brittney A. Cardinell, Jeffrey T. La Belle, Sarah E. Stabenfeldt, Caroline P. Addington
The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in Hematopoiesis
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Elizabeth Eklund
MicroRNAs as Diagnostic, Prognostic, and Therapeutic Biomarkers in Prostate Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 2
Faezeh Ghasemi, Atefeh Amiri, Hamed Mirzaei, Aria Masoudifar, Reza Salarinia, Arad Mobasher Aghdam
Development of Electrochemical Methods to Enzymatically Detect Lactate and Glucose Using Imaginary Impedance for Enhanced Management of Glycemic Compromised Patients
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 3
David Probst, Aldin Malkoc, Ayan Sen, Blake Morrow, Tiffany Gong, Jeffrey T. La Belle, Chi Lin
Chemokines in Respiratory Viral Infections: Focus on Their Diagnostic and Therapeutic Potential
Critical Reviews™ in Immunology, Vol.31, 2011, issue 4
Stavros Apostolakis, Demetrios A. Spandidos, Virginia Amanatidou, Apostolos Zaravinos