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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v18.i5.10
26 pages

Pulsatile Drug-Delivery Systems

Till Bussemer
College of Pharmacy, Freie Universitat Berlin, Kelchstr. 31, 12169 Berlin, Germany
Ina Otto
College of Pharmacy, Freie Universitat Berlin, Kelchstr. 31, 12169 Berlin, Germany
Roland Bodmeier
College of Pharmacy, Freie Universitat Berlin, Kelchstr. 31, 12169 Berlin, Germany

ABSTRAKT

Delivery systems with a pulsatile-release pattern are receiving increasing interest for the development of drugs for which conventional controlled drug-release systems with a continuous release are not ideal. These drugs often have a high first-pass effect or special chronopharmacological needs. A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile drug-delivery systems can be classified into site-specific systems in which the drug is released at the desired site within the intestinal tract (e.g., the colon), or time-controlled devices in which the drug is released after a well-defined time period. Site-controlled release is usually controlled by environmental factors, like the pH or enzymes present in the intestinal tract, whereas the drug release from time-controlled systems is controlled primarily by the delivery system and, ideally, not by the environment. This review covers various single- and multipleunit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.


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