Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
Indexed in
Quantum Dots and their Potential Role in Cancer Theranostics
ABSTRAKT
The emergence of cancer nanomedicine is the result of fruitful advances in the fields of nanotechnology, bioimaging, formulation development, and molecular biology. Quantum dots (QDs) are the luminescent nanocrystals (NCs) that provide a multifunctional platform for imaging the biosystems following controlled delivery of therapeutic drugs, proteins, peptides, oligonucleotides, and genes. These engineered fluorescent probes with integrated imaging and carrier functionalities have become excellent tools for molecular diagnostics and delivery of therapeutics molecules. Flexible surface chemistry, unique optical properties, high sensitivity, and multiplexing capabilities of QDs certainly make them a most promising tool for personalized medicine. This review focuses on state-of-art advances in synthesizing QDs and highlights the approaches used for functionalization of QDs with desired ligands for targeted carriage to specific sites. Discussed is the role of QDs in antitumor therapy through drug delivery and gene delivery and the recently emerged photodynamic therapy (PDT). We also endeavor to critically address the major impediments in the clinical development of these multifunctional nanoplatforms, with a special focus on plausible advancements for the near future.
-
Tripathi Surya Kant, Khurana Rajneet Kaur, Kaur Gurvir, Teenu , Singh Bhupinder, Quantum dots, in Nanobiomaterials in Medical Imaging, 2016. Crossref
-
Same Saeideh, Aghanejad Ayuob, Akbari Nakhjavani Sattar, Barar Jaleh, Omidi Yadollah, Radiolabeled theranostics: magnetic and gold nanoparticles, Bioimpacts, 6, 3, 2016. Crossref
-
Jain Kewal K., Nanobiotechnology and Personalized Medicine, in The Handbook of Nanomedicine, 2017. Crossref
-
Viard Mathias, Reichard Henry, Shapiro Bruce A., Durrani Farukh A, Marko Aimee J, Watson R Michelle, Pandey Ravindra K., Puri Anu, Design and biological activity of novel stealth polymeric lipid nanoparticles for enhanced delivery of hydrophobic photodynamic therapy drugs, Nanomedicine: Nanotechnology, Biology and Medicine, 14, 7, 2018. Crossref
-
Zhang Zhanxia, Dong Changsheng, Yu Guanzhen, Cheng Wei, Liang Yupei, Pan Yongfu, Li Hegen, Ji Hongbin, Smart and dual-targeted BSA nanomedicine with controllable release by high autolysosome levels, Colloids and Surfaces B: Biointerfaces, 182, 2019. Crossref
-
Wang Yinghui, Song Shuyan, Zhang Songtao, Zhang Hongjie, Stimuli-responsive nanotheranostics based on lanthanide-doped upconversion nanoparticles for cancer imaging and therapy: current advances and future challenges, Nano Today, 25, 2019. Crossref
-
Varanda Laudemir Carlos, Souza Caio Guilherme Secco de, Perecin Caio José, Moraes Daniel Angeli de, Queiróz Daniely Ferreira de, Neves Herbert Rodrigo, Souza Junior João Batista, Silva Mônica Freitas da, Albers Rebecca Faggion, Silva Tiago Luis da, Inorganic and organic–inorganic composite nanoparticles with potential biomedical applications: synthesis challenges for enhanced performance, in Materials for Biomedical Engineering, 2019. Crossref
-
Luo Z., Fang W., Wang C. L., Ma W. Q., Double Labeling and Simultaneous Monitoring for Hsp70 and Hsf-1 Kinetics in SCC-25 Cells with a Short-Term Dietary Restriction of Leucine Following Heat Shock, Molecular Biology, 53, 3, 2019. Crossref
-
Fan Hua-yang, Yu Xiang-hua, Wang Ke, Yin Yi-jia, Tang Ya-jie, Tang Ya-ling, Liang Xin-hua, Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment, European Journal of Medicinal Chemistry, 182, 2019. Crossref
-
Jain Kewal K., Non-genomic Aspects of Personalized Medicine, in Textbook of Personalized Medicine, 2021. Crossref
-
Sahu Bhanu P., Biswas Nikhil, Das Malay K., Multifunctional Nanoscale Particles for Theranostic Application in Healthcare, in Nano Medicine and Nano Safety, 2020. Crossref
-
Kukkar Deepak, Kukkar Preeti, Kumar Vanish, Hong Jongki, Kim Ki-Hyun, Deep Akash, Recent advances in nanoscale materials for antibody-based cancer theranostics, Biosensors and Bioelectronics, 173, 2021. Crossref
-
Misra Ranjita, Acharya Sarbari, Smart nanotheranostic hydrogels for on-demand cancer management, Drug Discovery Today, 26, 2, 2021. Crossref
-
Sahu Bhanu P., Biswas Nikhil, Das Malay K., Multifunctional nanotheranostics for cancer diagnosis and treatments, in Multifunctional Theranostic Nanomedicines in Cancer, 2021. Crossref
-
Aizik Gil, Waiskopf Nir, Agbaria Majd, Ben-David-Naim Meital, Levi-Kalisman Yael, Shahar Amit, Banin Uri, Golomb Gershon, Liposomes of Quantum Dots Configured for Passive and Active Delivery to Tumor Tissue, Nano Letters, 19, 9, 2019. Crossref
-
Icten Okan, Functional nanocomposites: promising candidates for cancer diagnosis and treatment, in Synthetic Inorganic Chemistry, 2021. Crossref
-
Ehlerding Emily B., Grodzinski Piotr, Cai Weibo, Liu Christina H., Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics, ACS Nano, 12, 3, 2018. Crossref
-
Kandasamy Ganeshlenin, Maity Dipak, Multifunctional theranostic nanoparticles for biomedical cancer treatments - A comprehensive review, Materials Science and Engineering: C, 127, 2021. Crossref
-
Jain Annish, Singh Sumit K., Arya Shailendra K., Kundu Subhas C., Kapoor Sonia, Protein Nanoparticles: Promising Platforms for Drug Delivery Applications, ACS Biomaterials Science & Engineering, 4, 12, 2018. Crossref
-
Misra Ranjita, Das Manasi, Biswas Pronama, Nanda Anima, EGFR targeted Mn-doped ZnO fluorescent nanocrystals for cancer theranostic application, Materials Today Communications, 26, 2021. Crossref
-
Montaseri Hanieh, Kruger Cherie Ann, Abrahamse Heidi, Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer, Pharmaceutics, 13, 3, 2021. Crossref
-
Aggarwal Nidhi, Choudhury Samraggi, Chibh Sonika, Panda Jiban Jyoti, Aptamer-nanoconjugates as emerging theranostic systems in neurodegenerative disorders, Colloid and Interface Science Communications, 46, 2022. Crossref
-
Liu Christina H., Tandon Pushpa, Russell Luisa M., Translational Nanodiagnostics for In Vivo Cancer Detection, in Nanotheranostics for Cancer Applications, 5, 2019. Crossref
-
Singh Bhupinder, Sharma Teenu, Kaur Ranjot, Saini Sumant, Kaur Ripandeep, Beg Sarwar, QbD-Steered Systematic Development of Drug Delivery Nanoconstructs: Vital Precepts, Retrospect and Prospects, in Biomedical Translational Research, 2022. Crossref
-
Wei Tingting, Zhang Ting, Tang Meng, An overview of quantum dots-induced immunotoxicity and the underlying mechanisms, Environmental Pollution, 311, 2022. Crossref
-
Gupta Anita, Gupta G. S., Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine, Journal of Nanoparticle Research, 24, 11, 2022. Crossref
-
Kafle Urmila, Agrawal Satish, Dash Alekha K., Injectable Nano Drug Delivery Systems for the Treatment of Breast Cancer, Pharmaceutics, 14, 12, 2022. Crossref