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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
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PEGylation: An Approach for Drug Delivery. A Review
ABSTRAKT
The current review presents an update on polyethylene glycol (PEG), which is widely used as a covalent modifier of macromolecules. This review discusses the polymers suitable for conjugation, their conjugation methods, and their properties. Proteins and bioactive substances can be chemically modified by binding synthetic macromolecules of PEG to the surface of these biomolecules. Protein and peptide PEGylation improves the biopharmaceutical properties of drugs−that is, increased stability, increased resistance to proteolytic inactivation, decreased to nonexistent immunogenicity, increased circulatory lives, and low toxicity. These altered properties improve the delivery and efficacy of proteins.
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Hurkat Pooja, Jain Aviral, Jain Ashish, Shilpi Satish, Gulbake Arvind, Jain Sanjay K., Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery, Journal of Nanoparticle Research, 14, 11, 2012. Crossref
-
Simón-Yarza Teresa, Formiga Fabio R., Tamayo Esther, Pelacho Beatriz, Prosper Felipe, Blanco-Prieto María J., PEGylated-PLGA microparticles containing VEGF for long term drug delivery, International Journal of Pharmaceutics, 440, 1, 2013. Crossref
-
Lee Hyun Jin, Bae Younsoo, Pharmaceutical Differences Between Block Copolymer Self-Assembled and Cross-Linked Nanoassemblies as Carriers for Tunable Drug Release, Pharmaceutical Research, 30, 2, 2013. Crossref
-
Liu Jian, Tabata Yasuhiko, Photodynamic Antitumor Activity of Fullerene Modified with Poly(ethylene glycol) with Different Molecular Weights and Terminal Structures, Journal of Biomaterials Science, Polymer Edition, 22, 1-3, 2011. Crossref
-
Jutz Günther, Böker Alexander, Bionanoparticles as functional macromolecular building blocks – A new class of nanomaterials, Polymer, 52, 2, 2011. Crossref
-
Tian Hong, Guo Yuan, Gao Xiangdong, Yao Wenbing, PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation, Journal of Pharmacy and Pharmacology, 65, 1, 2012. Crossref
-
Hu Xiao, Miller Larisa, Richman Sandra, Hitchman Stacy, Glick Gabrielle, Liu Shifang, Zhu Ying, Crossman Mary, Nestorov Ivan, Gronke Robert S., Baker Darren P., Rogge Mark, Subramanyam Meena, Davar Gudarz, A Novel PEGylated Interferon Beta-1a for Multiple Sclerosis: Safety, Pharmacology, and Biology, The Journal of Clinical Pharmacology, 52, 6, 2012. Crossref
-
Siegal T., Which drug or drug delivery system can change clinical practice for brain tumor therapy?, Neuro-Oncology, 15, 6, 2013. Crossref
-
Schou-Pedersen Anne Marie V., Østergaard Jesper, Johansson Mats, Dubant Stephane, Frederiksen Rune B., Hansen Steen Honoré, Evaluation of supercritical fluid chromatography for testing of PEG adducts in pharmaceuticals, Journal of Pharmaceutical and Biomedical Analysis, 88, 2014. Crossref
-
Mariniello L., Porta R., Sorrentino A., Giosafatto C. V. L., Rossi Marquez G., Esposito M., Di Pierro P., Transglutaminase-mediated macromolecular assembly: production of conjugates for food and pharmaceutical applications, Amino Acids, 46, 3, 2014. Crossref
-
XIAO Xi-Feng, JIANG Xiao-Qun, ZHOU Lei-Ji, Surface Modification of Poly Ethylene Glycol to Resist Nonspecific Adsorption of Proteins, Chinese Journal of Analytical Chemistry, 41, 3, 2013. Crossref
-
Song Danny Y., Herfarth Klaus K., Uhl Matthias, Eble Michael J., Pinkawa Michael, van Triest Baukelien, Kalisvaart Robin, Weber Damien C., Miralbell Raymond, DeWeese Theodore L., Ford Eric C., A Multi-institutional Clinical Trial of Rectal Dose Reduction via Injected Polyethylene-Glycol Hydrogel During Intensity Modulated Radiation Therapy for Prostate Cancer: Analysis of Dosimetric Outcomes, International Journal of Radiation Oncology*Biology*Physics, 87, 1, 2013. Crossref
-
Povoski Stephen P, Davis Paul D, Colcher David, Martin Jr Edward W, Single molecular weight discrete PEG compounds: emerging roles in molecular diagnostics, imaging and therapeutics, Expert Review of Molecular Diagnostics, 13, 4, 2013. Crossref
-
Lin Wan-Ing, Lin Chien-Yuan, Lin Yu-Shen, Wu Si-Han, Huang Yu-Ru, Hung Yann, Chang Chen, Mou Chung-Yuan, High payload Gd(iii) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging, J. Mater. Chem. B, 1, 5, 2013. Crossref
-
Dohnal V., Maly J., Havlickova M., Semeradtova A., Herman D., Kuca K., A New Concept in the Separation of Polyethyleneglycol-Modified PAMAM Dendrons by Liquid Chromatography, Journal of Chromatographic Science, 52, 4, 2014. Crossref
-
Nordling-David Mirjam M., Golomb Gershon, Gene Delivery by Liposomes, Israel Journal of Chemistry, 2013. Crossref
-
Mandal Bivash, Bhattacharjee Himanshu, Mittal Nivesh, Sah Hongkee, Balabathula Pavan, Thoma Laura A., Wood George C., Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform, Nanomedicine: Nanotechnology, Biology and Medicine, 9, 4, 2013. Crossref
-
Kumar Anil, Chen Fei, Mozhi Anbu, Zhang Xu, Zhao Yuanyuan, Xue Xiangdong, Hao Yanli, Zhang Xiaoning, Wang Paul C., Liang Xing-Jie, Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation, Nanoscale, 5, 18, 2013. Crossref
-
Yoon Kwonhyeok, Kang Han Chang, Li Li, Cho Hana, Park Mi-Kyoung, Lee Eunji, Bae You Han, Huh Kang Moo, Amphiphilic poly(ethylene glycol)-poly(ε-caprolactone) AB2 miktoarm copolymers for self-assembled nanocarrier systems: synthesis, characterization, and effects of morphology on antitumor activity, Polymer Chemistry, 6, 4, 2015. Crossref
-
Lazarjani Hamideh Aghajani, Vasheghani-Farahani Ebrahim, Barani Leila, Hashemi-Najafabadi Sameereh, Shojaosadati Seyed Abbas, Zahediasl Saleh, Tairahi Taki, Atyabi Fatemeh, Effect of Polymer Concentration on Camouflaging of Pancreatic Islets with mPEG-succinimidyl Carbonate, Artificial Cells, Blood Substitutes, and Biotechnology, 38, 5, 2010. Crossref
-
Radermacher Kim A., Beghein Nelson, Boutry Sebastien, Laurent Sophie, Elst Luce Vander, Muller Robert N., Jordan Benedicte F., Gallez Bernard, In Vivo Detection of Inflammation Using Pegylated Iron Oxide Particles Targeted at E-Selectin, Investigative Radiology, 44, 7, 2009. Crossref
-
Nelson Aaron L., Antibody fragments, mAbs, 2, 1, 2010. Crossref
-
Pasut Gianfranco, Paolino Donatella, Celia Christian, Mero Anna, Joseph Adrian Steve, Wolfram Joy, Cosco Donato, Schiavon Oddone, Shen Haifa, Fresta Massimo, Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy, Journal of Controlled Release, 199, 2015. Crossref
-
Calabresi Peter A, Kieseier Bernd C, Arnold Douglas L, Balcer Laura J, Boyko Alexey, Pelletier Jean, Liu Shifang, Zhu Ying, Seddighzadeh Ali, Hung Serena, Deykin Aaron, Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study, The Lancet Neurology, 13, 7, 2014. Crossref
-
Van Camp Wim, Dispinar Tugba, Dervaux Bart, Prez Filip E. Du, Martins José C., Fritzinger Bernd, ‘Click’ Functionalization of Cryogels Conveniently Verified and Quantified Using High-Resolution MAS NMR Spectroscopy, Macromolecular Rapid Communications, 30, 15, 2009. Crossref
-
Kliger Yossef, Computational approaches to therapeutic peptide discovery, Biopolymers, 94, 6, 2010. Crossref
-
Brandenberger Christina, Mühlfeld Christian, Ali Zulqurnain, Lenz Anke-Gabriele, Schmid Otmar, Parak Wolfgang J., Gehr Peter, Rothen-Rutishauser Barbara, Quantitative Evaluation of Cellular Uptake and Trafficking of Plain and Polyethylene Glycol-Coated Gold Nanoparticles, Small, 6, 15, 2010. Crossref
-
Lee Seung Yeon, Oh Seaung Youl, Alteration of electroosmotic volume flow through skin by polyethylene glycols, Archives of Pharmacal Research, 38, 7, 2015. Crossref
-
Moret Francesca, Selvestrel Francesco, Lubian Elisa, Mognato Maddalena, Celotti Lucia, Mancin Fabrizio, Reddi Elena, PEGylation of ORMOSIL nanoparticles differently modulates the in vitro toxicity toward human lung cells, Archives of Toxicology, 89, 4, 2015. Crossref
-
Broyer Rebecca M., Grover Gregory N., Maynard Heather D., Emerging synthetic approaches for protein–polymer conjugations, Chemical Communications, 47, 8, 2011. Crossref
-
Grund Stefan, Bauer Marius, Fischer Dagmar, Polymers in Drug Delivery-State of the Art and Future Trends, Advanced Engineering Materials, 13, 3, 2011. Crossref
-
Hu Xiao, Seddighzadeh Ali, Stecher Scott, Zhu Ying, Goyal Jaya, Matson Mark, Marbury Thomas, Smith William, Nestorov Ivan, Hung Serena, Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta‐1a in subjects with normal or impaired renal function, The Journal of Clinical Pharmacology, 55, 2, 2015. Crossref
-
Schou-Pedersen Anne Marie V., Hansen Steen Honoré, Moesgaard Birthe, Østergaard Jesper, Kinetics of the Esterification of Active Pharmaceutical Ingredients Containing Carboxylic Acid Functionality in Polyethylene Glycol: Formulation Implications, Journal of Pharmaceutical Sciences, 103, 8, 2014. Crossref
-
Pisal Dipak S., Kosloski Matthew P., Balu-Iyer Sathy V., Delivery of Therapeutic Proteins, Journal of Pharmaceutical Sciences, 99, 6, 2010. Crossref
-
Liu Zhendong, Ren Yinling, Pan Li, Xu Han-Mei, In Vivo Anti-Tumor Activity of Polypeptide HM-3 Modified by Different Polyethylene Glycols (PEG), International Journal of Molecular Sciences, 12, 4, 2011. Crossref
-
Tao Weikang, Davide Joseph P, Cai Mingmei, Zhang Guo-Jun, South Victoria J, Matter Andrea, Ng Bruce, Zhang Ye, Sepp-Lorenzino Laura, Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver, Molecular Therapy, 18, 9, 2010. Crossref
-
Zhao Yunqi, Zhang Ti, Duan Shaofeng, Davies Neal M., Forrest M. Laird, CD44-tropic polymeric nanocarrier for breast cancer targeted rapamycin chemotherapy, Nanomedicine: Nanotechnology, Biology and Medicine, 10, 6, 2014. Crossref
-
Ye Yun-Sheng, Rick John, Hwang Bing-Joe, Water Soluble Polymers as Proton Exchange Membranes for Fuel Cells, Polymers, 4, 2, 2012. Crossref
-
Wonganan Piyanuch, Croyle Maria A., PEGylated Adenoviruses: From Mice to Monkeys, Viruses, 2, 2, 2010. Crossref
-
Schweiger Christoph, Pietzonka Clemens, Heverhagen Johannes, Kissel Thomas, Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: Synthesis, stability, cytotoxicity and MR imaging, International Journal of Pharmaceutics, 408, 1-2, 2011. Crossref
-
Høiberg-Nielsen R., Westh P., Skov L.K., Arleth L., Interrelationship of Steric Stabilization and Self-Crowding of a Glycosylated Protein, Biophysical Journal, 97, 5, 2009. Crossref
-
Zhang Bing, Towers Edward W., Poppe Leszek, Cockrill Steven L., Analytical characterization of a novel degradation product in a PEGylated recombinant protein, Journal of Pharmaceutical Sciences, 100, 11, 2011. Crossref
-
Kieseier Bernd C., Calabresi Peter A., PEGylation of Interferon-β-1a, CNS Drugs, 26, 3, 2012. Crossref
-
Moll G.N., Kuipers A., de Vries L., Bosma T., Rink R., A biological stabilization technology for peptide drugs: enzymatic introduction of thioether-bridges, Drug Discovery Today: Technologies, 6, 1-4, 2009. Crossref
-
Merkle Hans P., Drug delivery’s quest for polymers: Where are the frontiers?, European Journal of Pharmaceutics and Biopharmaceutics, 97, 2015. Crossref
-
Li Li, Huh Kang Moo, Polymeric nanocarrier systems for photodynamic therapy, Biomaterials Research, 18, 1, 2014. Crossref
-
Rosés Cristina, Carbajo Daniel, Sanclimens Glòria, Farrera-Sinfreu Josep, Blancafort Adriana, Oliveras Glòria, Cirac Anna D., Bardají Eduard, Puig Teresa, Planas Marta, Feliu Lidia, Albericio Fernando, Royo Miriam, Cell-penetrating γ-peptide/antimicrobial undecapeptide conjugates with anticancer activity, Tetrahedron, 68, 23, 2012. Crossref
-
Khan Umair Tahir, Tanasescu Radu, Constantinescu Cris S, PEGylated IFNβ-1a in the treatment of multiple sclerosis, Expert Opinion on Biological Therapy, 15, 7, 2015. Crossref
-
Szlachcic Anna, Zakrzewska Malgorzata, Otlewski Jacek, Longer action means better drug: Tuning up protein therapeutics, Biotechnology Advances, 29, 4, 2011. Crossref
-
Jiang Xiu-Mei, Wang Li-Ming, Chen Chun-Ying, Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles, Journal of the Chinese Chemical Society, 58, 3, 2011. Crossref
-
Bunker Alex, Molecular Modeling as a Tool to Understand the Role of Poly(Ethylene) Glycol in Drug Delivery, in Computational Pharmaceutics, 2015. Crossref
-
Maullu Carlo, Raimondo Domenico, Caboi Francesca, Giorgetti Alejandro, Sergi Mauro, Valentini Maria, Tonon Giancarlo, Tramontano Anna, Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor, FEBS Journal, 276, 22, 2009. Crossref
-
Bhattacharyya Aditi, Mukhopadhyay Piyasi, Pramanik Nilkamal, Kundu Patit P., Effect of Polyethylene Glycol on Bis(2-hydroxyethyl) terephthalate-Based Polyurethane/Alginate pH-Sensitive Blend for Oral Protein Delivery, Advances in Polymer Technology, 35, 1, 2016. Crossref
-
Lonshakov D. V., Sheremet'ev S. V., Belosludtseva E. M., Korovkin S. A., Semchenko A. V., Katlinskij A. V., Synthesis of 4-aminobenzoic acid esters of polyethylene glycol and their use for pegylation of therapeutic proteins, RSC Advances, 5, 53, 2015. Crossref
-
Yang Bing-Bing, Kido Anna, Pharmacokinetics and Pharmacodynamics of Pegfilgrastim, Clinical Pharmacokinetics, 50, 5, 2011. Crossref
-
Unterman Shimon A., Marcus Norman A., Elisseeff Jennifer H., Injectable Polymers, in Biodegradable Polymers in Clinical Use and Clinical Development, 2011. Crossref
-
Leussink V.I., Warnke C., Tackenberg B., Wiendl H., Kieseier B.C., Pegyliertes Interferon-beta 1a, Der Nervenarzt, 86, 4, 2015. Crossref
-
Yin Jun, Bao Lichen, Tian Hong, Wang Qun, Gao Xiangdong, Yao Wenbing, Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity, British Journal of Pharmacology, 173, 14, 2016. Crossref
-
Rodrigo Gustav, Gruvegård Mats, Van Alstine James, Antibody Fragments and Their Purification by Protein L Affinity Chromatography, Antibodies, 4, 3, 2015. Crossref
-
Otvos L., Basic Principles of Formulation for Biotherapeutics: Approaches to Alternative Drug Delivery, in Comprehensive Medicinal Chemistry III, 2017. Crossref
-
Pillai Gopikrishna J., Paul-Prasanth Bindhu, Nair Shantikumar V., Menon Deepthy, Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation, Colloids and Surfaces B: Biointerfaces, 150, 2017. Crossref
-
Hanafy Nemany A., Ferraro Marzia Maria, Gaballo Antonio, Dini Luciana, Tasco Vittorianna, Nobile Concetta, De Giorgi Maria Luisa, Carallo Sonia, Rinaldi Ross, Leporatti Stefano, Fabrication and characterization of ALK1fc-loaded fluoro-magnetic nanoparticles for inhibiting TGF β1 in hepatocellular carcinoma, RSC Advances, 6, 54, 2016. Crossref
-
Lee Jae H. T., Roy Josee, Moon Sohn Hong, Cheong Mi, Liu Jie, Stammers Anthea T., Tetzlaff Wolfram, Kwon Brian K., Magnesium in a Polyethylene Glycol Formulation Provides Neuroprotection After Unilateral Cervical Spinal Cord Injury, Spine, 35, 23, 2010. Crossref
-
Carbone Erica J., Rajpura Komal, Allen Brittany N., Cheng Emily, Ulery Bret D., Lo Kevin W.-H., Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties, Nanomedicine: Nanotechnology, Biology and Medicine, 13, 1, 2017. Crossref
-
Zhang Liang, Bhatnagar Sumit, Deschenes Emily, Thurber Greg M., Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design, Scientific Reports, 6, 1, 2016. Crossref
-
Jain Aviral, Chasoo Gousia, Singh Shashank K., Saxena Ajit K., Jain Sanjay K., Transferrin-appended PEGylated nanoparticles for temozolomide delivery to brain:in vitrocharacterisation, Journal of Microencapsulation, 28, 1, 2011. Crossref
-
Edward Semple J., Sullivan Bradford, Vojkovsky Tomas, Sill Kevin N., Synthesis and facile end‐group quantification of functionalized PEG azides, Journal of Polymer Science Part A: Polymer Chemistry, 54, 18, 2016. Crossref
-
Benetti Edmondo M., Gunnewiek Michel Klein, van Blitterswijk Clemens A., Julius Vancso G., Moroni Lorenzo, Mimicking natural cell environments: design, fabrication and application of bio-chemical gradients on polymeric biomaterial substrates, Journal of Materials Chemistry B, 4, 24, 2016. Crossref
-
Fang Fei, Zou Dan, Wang Wei, Yin Ying, Yin Tieying, Hao Shilei, Wang Bochu, Wang Guixue, Wang Yazhou, Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport, Materials Science and Engineering: C, 76, 2017. Crossref
-
Wang Sheng-Hung, Yu John, Structure-based design for binding peptides in anti-cancer therapy, Biomaterials, 156, 2018. Crossref
-
Santander-Ortega M.J., Plaza-Oliver M., Rodríguez-Robledo V., Castro-Vázquez L., Villaseca-González N., González-Fuentes J., Marcos P., Arroyo-Jiménez M.M., Lozano M.V., Colloids for drug delivery to the brain, Journal of Drug Delivery Science and Technology, 42, 2017. Crossref
-
Kieseier Bernd C, Arnold Douglas L, Balcer Laura J, Boyko Alexey A, Pelletier Jean, Liu Shifang, Zhu Ying, Seddighzadeh Ali, Hung Serena, Deykin Aaron, Sheikh Sarah I, Calabresi Peter A, Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE, Multiple Sclerosis Journal, 21, 8, 2015. Crossref
-
Arndt P., Leistner N. D., Neuss S., Kaltbeitzel D., Brook G. A., Grosse J., Artificial urine and FBS supplemented media in cytocompatibility assays for PLGA-PEG-based intravesical devices using the urothelium cell line UROtsa, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106, 6, 2018. Crossref
-
Arnold Douglas L., Calabresi Peter A., Kieseier Bernd C., Liu Shifang, You Xiaojun, Fiore Damian, Hung Serena, Peginterferon beta-1a improves MRI measures and increases the proportion of patients with no evidence of disease activity in relapsing-remitting multiple sclerosis: 2-year results from the ADVANCE randomized controlled trial, BMC Neurology, 17, 1, 2017. Crossref
-
Horák Daniel, Hlidková Helena, Klyuchivska Olga, Grytsyna Iryna, Stoika Rostyslav, PEGylation controls attachment and engulfment of monodisperse magnetic poly(2-hydroxyethyl methacrylate) microspheres by murine J774.2 macrophages, Applied Surface Science, 426, 2017. Crossref
-
Salahuddin Nehal, Galal Ahmed, Improving chemotherapy drug delivery by nanoprecision tools, in Nanostructures for Cancer Therapy, 2017. Crossref
-
Hall Shaun A., Hickey Ashley D., Hore Dennis K., Structure of Phenylalanine Adsorbed on Polystyrene from Nonlinear Vibrational Spectroscopy Measurements and Electronic Structure Calculations, The Journal of Physical Chemistry C, 114, 21, 2010. Crossref
-
Ando Mitsuru, Takahashi Yuki, Nishikawa Makiya, Takakura Yoshinobu, Control of Spatiotemporal Distribution of Interferon γ by Genetically Fusing Functional Peptides, YAKUGAKU ZASSHI, 132, 12, 2012. Crossref
-
Lin Wei-Han, Lin Che-Yu, Tsai Ching-Cheng, Yu Jiashing, Tsai Wei-Bor, Spheroid Formation of Human Adipose-Derived Stem Cells on Environmentally Friendly BMA/SBMA/HEMA Copolymer-Coated Anti-Adhesive Surface, Bulletin of the Chemical Society of Japan, 91, 9, 2018. Crossref
-
Gowda Raghavendra, Dinavahi Saketh S., Iyer Soumya, Banerjee Shubhadeep, Neves Rogerio I., Pameijer Colette R., Robertson Gavin P., Nanoliposomal delivery of cytosolic phospholipase A2 inhibitor arachidonyl trimethyl ketone for melanoma treatment, Nanomedicine: Nanotechnology, Biology and Medicine, 14, 3, 2018. Crossref
-
Reimann Oliver, Seitz Oliver, Sarma Dominik, Zitterbart Robert, A traceless catch-and-release method for rapid peptide purification, Journal of Peptide Science, 25, 1, 2019. Crossref
-
Alharbi Hanan M., Campbell Robert B., Nano-formulations composed of cell membrane-specific cellular lipid extracts derived from target cells: physicochemical characterization and in vitro evaluation using cellular models of breast carcinoma, AAPS Open, 4, 1, 2018. Crossref
-
González-Rodríguez María Luisa, Cózar-Bernal María José, Fini Adamo, Rabasco Antonio María, Surface-Charged Vesicles for Penetration Enhancement, in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement, 2016. Crossref
-
Mah Li-Jeen, Tortorella Stephanie, Karagiannis Tom C., Nano-Based Drug Delivery Modalities for the Treatment of Cancer: The Formulation of Tumour-Specific and -Targeted Nanoparticles, in Molecular mechanisms and physiology of disease, 2014. Crossref
-
Siegal Tali, Which Drug or Drug Delivery Method Can Change Clinical Practice for Brain Tumor Therapy?, in Drug Delivery to the Brain, 10, 2014. Crossref
-
Sharma Ashish, Kumar Nilesh, Kuppermann Baruch D., Bandello Francesco, Brolucizimab—leading an era of structural revolution for long-term VEGF suppression, Eye, 34, 4, 2020. Crossref
-
Bates Adam, Power Christine A., David vs. Goliath: The Structure, Function, and Clinical Prospects of Antibody Fragments, Antibodies, 8, 2, 2019. Crossref
-
Thorpe Alice, Freeman Helen, Pradhananga Sarbendra L., Wilkinson Ian R., Ross Richard J. M., Long-Acting Growth Hormone Analogues, in Growth Hormone Related Diseases and Therapy, 2011. Crossref
-
Melnikov M. V., Kasatkin D. S., Volkov A. I., Boyko A. N., The pegylated form of interferon beta in the treatment of multiple sclerosis, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 119, 8, 2019. Crossref
-
Rao Arjun Sunil, Rashmi K.R., Manjunatha D.V., Jayarama A., Veena Devi Shastrimath V., Pinto Richard, Methanol crossover reduction and power enhancement of methanol fuel cells with polyvinyl alcohol coated Nafion membranes, Materials Today: Proceedings, 35, 2021. Crossref
-
Amatya Reeju, Park Taehoon, Hwang Seungmi, Yang JaeWook, Lee Yoonjin, Cheong Heesun, Moon Cheol, Kwak Hyun Duck, Min Kyoung Ah, Shin Meong Cheol, Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides, Toxins, 12, 5, 2020. Crossref
-
Aghamiri Shahin, Talaei Sam, Ghavidel Afshin Abdi, Zandsalimi Farshid, Masoumi Saeid, Hafshejani Nahid Heidari, Jajarmi Vahid, Nanoparticles-mediated CRISPR/Cas9 delivery: Recent advances in cancer treatment, Journal of Drug Delivery Science and Technology, 56, 2020. Crossref
-
Zhang Zhi, Zhang Yuyao, Song Shiwen, Yin Lei, Sun Dong, Gu Jingkai, Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals, Journal of Separation Science, 43, 9-10, 2020. Crossref
-
Nandi Uttom, Onyesom Ichioma, Douroumis Dennis, Anti-cancer activity of sirolimus loaded liposomes in prostate cancer cell lines, Journal of Drug Delivery Science and Technology, 61, 2021. Crossref
-
Kumar Pawan, Saini Meenu, Dehiya Brijnandan S., Sindhu Anil, Kumar Vinod, Kumar Ravinder, Lamberti Luciano, Pruncu Catalin I., Thakur Rajesh, Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications, Nanomaterials, 10, 10, 2020. Crossref
-
Findling Oliver, Sellner Johann, Second-generation immunotherapeutics in multiple sclerosis: can we discard their precursors?, Drug Discovery Today, 26, 2, 2021. Crossref
-
Jain Harsha, Bairagi Arpita, Srivastava Saurabh, Singh Shashi Bala, Mehra Neelesh Kumar, Recent advances in the development of microparticles for pulmonary administration, Drug Discovery Today, 25, 10, 2020. Crossref
-
Nordeman P., Jayendra Z.P., Briard E., Li S.C., Larhed M., Antoni G., Estrada S., Selvaraju R.K., Åberg O., Jensen M.R., Stålberg P., Skogseid B., Monazzam A., 18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand, European Journal of Pharmaceutical Sciences, 157, 2021. Crossref
-
Li Chang, Liu Xiaoyu, Zhang Yanli, Lv Juan, Huang Fan, Wu Gang, Liu Ying, Ma Rujiang, An Yingli, Shi Linqi, Nanochaperones Mediated Delivery of Insulin, Nano Letters, 20, 3, 2020. Crossref
-
Ding Haiming, Carlton Michelle M., Povoski Stephen P., Milum Keisha, Kumar Krishan, Kothandaraman Shankaran, Hinkle George H., Colcher David, Brody Rich, Davis Paul D., Pokora Alex, Phelps Mitchell, Martin Edward W., Tweedle Michael F., Site Specific Discrete PEGylation of 124I-Labeled mCC49 Fab′ Fragments Improves Tumor MicroPET/CT Imaging in Mice, Bioconjugate Chemistry, 24, 11, 2013. Crossref
-
Averick Saadyah E., Paredes Eduardo, Grahacharya Debasish, Woodman Bradley F., Miyake-Stoner Shigeki J., Mehl Ryan A., Matyjaszewski Krzysztof, Das Subha R., A Protein–Polymer Hybrid Mediated By DNA, Langmuir, 28, 4, 2012. Crossref
-
Chou Chih-Hung, Lin Po-Chiao, Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG–Polymer Conjugates with Preserved Biological Activity, Biomacromolecules, 19, 7, 2018. Crossref
-
Bouchard P.R., Hutabarat R.M., Thompson K.M., Discovery and Development of Therapeutic Aptamers, Annual Review of Pharmacology and Toxicology, 50, 1, 2010. Crossref
-
Sheremet’ev S. V., Lonshakov D. V., Korovkin S. A., Belosludtseva E. M., Katlinskii A. V., Semchenko A. V., Borisova O. V., Synthesis and Pharmacological Properties of Linear Poly(Ethylene Glycol)s Conjugated to Interferon α-2b by Azo Coupling, Pharmaceutical Chemistry Journal, 50, 12, 2017. Crossref
-
Ilmi Rashid, Tseriotou Eleni, Stylianou Panayiota, Christou Yiota A., Ttofi Iakovia, Dietis Nikolas, Pitris Costas, Odysseos Andreani D., Georgiades Savvas N., A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria, Molecular Pharmaceutics, 16, 10, 2019. Crossref
-
Prashanth Jutty Rajan, Brust Andreas, Jin Ai-Hua, Alewood Paul F, Dutertre Sébastien, Lewis Richard J, Cone snail venomics: from novel biology to novel therapeutics, Future Medicinal Chemistry, 6, 15, 2014. Crossref
-
Molino Nicholas M., Neek Medea, Tucker Jo Anne, Nelson Edward L., Wang Szu-Wen, Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells, ACS Biomaterials Science & Engineering, 3, 4, 2017. Crossref
-
Byrd Richard A., Blackbourne Jamie L., Knadler Mary Pat, Schultze Albert E., Vahle John L., Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action, Toxicologic Pathology, 45, 3, 2017. Crossref
-
Kim Yu Jeong, Liu Yarong, Li Si, Rohrs Jennifer, Zhang Rachel, Zhang Xiaoyang, Wang Pin, Co-Eradication of Breast Cancer Cells and Cancer Stem Cells by Cross-Linked Multilamellar Liposomes Enhances Tumor Treatment, Molecular Pharmaceutics, 12, 8, 2015. Crossref
-
Wolak Daniel J., Thorne Robert G., Diffusion of Macromolecules in the Brain: Implications for Drug Delivery, Molecular Pharmaceutics, 10, 5, 2013. Crossref
-
Bahou Calise, Szijj Peter A., Spears Richard J., Wall Archie, Javaid Faiza, Sattikar Afrah, Love Elizabeth A., Baker James R., Chudasama Vijay, A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability, Bioconjugate Chemistry, 32, 4, 2021. Crossref
-
Trimaille Thomas, Mabrouk Kamel, Monnier Valérie, Charles Laurence, Bertin Denis, Gigmes Didier, SG1-Functionalized Peptides as Precursors for Polymer−Peptide Conjugates: A Straightforward Approach, Macromolecules, 43, 11, 2010. Crossref
-
Zhang Huixiang, Annunziata Onofrio, Diffusion of an Ionic Drug in Micellar Aqueous Solutions, Langmuir, 25, 6, 2009. Crossref
-
Guan Fuyu, Uboh Cornelius E., Soma Lawrence R., Maylin George, Jiang Zibin, Chen Jinwen, Confirmatory Analysis of Continuous Erythropoietin Receptor Activator and Erythropoietin Analogues in Equine Plasma by LC−MS for Doping Control, Analytical Chemistry, 82, 21, 2010. Crossref
-
Lieser Rachel M., Yur Daniel, Sullivan Millicent O., Chen Wilfred, Site-Specific Bioconjugation Approaches for Enhanced Delivery of Protein Therapeutics and Protein Drug Carriers, Bioconjugate Chemistry, 31, 10, 2020. Crossref
-
Wonganan Piyanuch, Clemens Courtney C., Brasky Kathy, Pastore Lucio, Croyle Maria A., Species Differences in the Pharmacology and Toxicology of PEGylated Helper-Dependent Adenovirus, Molecular Pharmaceutics, 8, 1, 2011. Crossref
-
Wu Yuanzheng, Li Jishun, Shin Hyun-Jae, Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles, Biotechnology and Bioprocess Engineering, 26, 1, 2021. Crossref
-
Georgianna Wesleigh E., Lusic Hrvoje, McIver Andrew L., Deiters Alexander, Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function, Bioconjugate Chemistry, 21, 8, 2010. Crossref
-
Hall Shaun A., Jena Kailash C., Trudeau Travis G., Hore Dennis K., Structure of Leucine Adsorbed on Polystyrene from Nonlinear Vibrational Spectroscopy Measurements, Molecular Dynamics Simulations, and Electronic Structure Calculations, The Journal of Physical Chemistry C, 115, 22, 2011. Crossref
-
McInnes Steven JP, Voelcker Nicolas H, Silicon–polymer hybrid materials for drug delivery, Future Medicinal Chemistry, 1, 6, 2009. Crossref
-
Liu Chen-Wei, Xiong Feng, Jia Hui-Zhen, Wang Xu-Li, Cheng Han, Sun Yong-Hua, Zhang Xian-Zheng, Zhuo Ren-Xi, Feng Jun, Graphene-Based Anticancer Nanosystem and Its Biosafety Evaluation Using a Zebrafish Model, Biomacromolecules, 14, 2, 2013. Crossref
-
Wei Weipeng, Ma Denglei, Li Lin, Zhang Lan, Progress in the Application of Drugs for the Treatment of Multiple Sclerosis, Frontiers in Pharmacology, 12, 2021. Crossref
-
Kubilius Matthew B., Tu Raymond S., Circular Dichroistic Impacts of 1-(3-Dimethylaminopropyl)-3-ethylurea: Secondary Structure Artifacts Arising from Bioconjugation Using 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide, ACS Omega, 2, 11, 2017. Crossref
-
Xu Jing, Bussiere Jeanine, Yie Junming, Sickmier Allen, An Phil, Belouski Ed, Stanislaus Shanaka, Walker Kenneth W., Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation, Bioconjugate Chemistry, 24, 6, 2013. Crossref
-
Wei Kongchang, Li Jun, Chen Guosong, Jiang Ming, Dual Molecular Recognition Leading to a Protein–Polymer Conjugate and Further Self-Assembly, ACS Macro Letters, 2, 3, 2013. Crossref
-
Dadashzadeh A., Moghassemi S., Amorim C.A., Evaluation of PEGylated fibrin as a three-dimensional biodegradable scaffold for ovarian tissue engineering, Materials Today Chemistry, 22, 2021. Crossref
-
Irizarry Rovira Armando R., Bennet Bindu M., Bolon Brad, Braendli-Baiocco Annamaria, Chandra Sundeep, Fleurance Renaud, Garman Robert, Hutto David, Lane Joan, Romeike Annette, Sargeant Aaron, Zimmerman Bevin, Scientific and Regulatory Policy Committee Points to Consider: Histopathologic Evaluation in Safety Assessment Studies for PEGylated Pharmaceutical Products, Toxicologic Pathology, 46, 6, 2018. Crossref
-
Ramadi Khalil B., Dagdeviren Canan, Spencer Kevin C., Joe Pauline, Cotler Max, Rousseau Erin, Nunez-Lopez Carlos, Graybiel Ann M., Langer Robert, Cima Michael J., Focal, remote-controlled, chronic chemical modulation of brain microstructures, Proceedings of the National Academy of Sciences, 115, 28, 2018. Crossref
-
Zhang Yanli, Li Chang, Wu Xiaohui, Deng Fei, Huang Fan, Zhang Yumin, Liu Jinjian, Gui Han, Ma Rujiang, Shi Linqi, Nanochaperones tailored for insulin delivery to reduce immune clearance and enhance bioavailability of insulin, Chemical Engineering Journal, 435, 2022. Crossref
-
Li Ting, Yang Na, Teng Da, Mao Ruoyu, Hao Ya, Wang Xiumin, Wang Jianhua, C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo, BMC Microbiology, 22, 1, 2022. Crossref
-
Darling Jama M., Lemon Stanley M., Fried Michael W., Hepatitis C, in Schiff's Diseases of the Liver, 2011. Crossref
-
Gowda Raghavendra, Madhunapantula SubbaRao V., Sharma Arati, Kuzu Omer F., Robertson Gavin P., Nanolipolee-007, a Novel Nanoparticle-Based Drug Containing Leelamine for the Treatment of Melanoma, Molecular Cancer Therapeutics, 13, 10, 2014. Crossref
-
Metzger Friedrich, Sajid Waseem, Saenger Stefanie, Staudenmaier Christian, van der Poel Chris, Sobottka Bettina, Schuler Angelika, Sawitzky Mandy, Poirier Raphael, Tuerck Dietrich, Schick Eginhard, Schaubmar Andreas, Hesse Friederike, Amrein Kurt, Loetscher Hansruedi, Lynch Gordon S., Hoeflich Andreas, De Meyts Pierre, Schoenfeld Hans-Joachim, Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I), Journal of Biological Chemistry, 286, 22, 2011. Crossref
-
Shakesheff Kevin M., Drug Delivery Systems, in Handbook of Biodegradable Polymers, 2011. Crossref
-
Afrin Humayra, Salazar Christiancel Joseph, Kazi Mohsin, Ahamad Syed Rizwan, Alharbi Majed, Nurunnabi Md, Methods of screening, monitoring and management of cardiac toxicity induced by chemotherapeutics, Chinese Chemical Letters, 33, 6, 2022. Crossref
-
Bastos Verónica, Ferreira-de-Oliveira José M.P., Carrola Joana, Daniel-da-Silva Ana L., Duarte Iola F., Santos Conceição, Oliveira Helena, Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line, Journal of Environmental Sciences, 51, 2017. Crossref
-
Racz Levente Zsolt, Racz Csaba Pal, Pop Lucian-Cristian, Tomoaia Gheorghe, Mocanu Aurora, Barbu Ioana, Sárközi Melinda, Roman Ioana, Avram Alexandra, Tomoaia-Cotisel Maria, Toma Vlad-Alexandru, Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin, Molecules, 27, 20, 2022. Crossref
-
Ribeiro Maria H., Martins Samuel L., Bioencapsulation of proteins in therapeutics, in Smart Nanomaterials for Bioencapsulation, 2022. Crossref
-
Pandian Sureshbabu Ram Kumar, Vijayakumar Kevin Kumar, Murugesan Sankaranarayanan, Kunjiappan Selvaraj, Liposomes: An emerging carrier for targeting Alzheimer's and Parkinson's diseases, Heliyon, 8, 6, 2022. Crossref