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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v24.i6.20
pages 547-596

Microemulsions: Applications in Transdermal and Dermal Delivery

Abhijit A. Date
Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai-400 098, India
Vandana B. Patravale
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, Maharashtra, India

ABSTRAKT

Microemulsions have gained much interest as second-generation colloidal carrier systems for the dermal/transdermal delivery of the various hydrophilic and lipophilic drugs. The advantages associated with microemulsions include spontaneity of formation, ease of manufacturing, high solubilization capacity, and improved drug stability. This review focuses on the excipients available for the formulation of topical microemulsions and the potential mechanisms responsible for improvements in the dermal/transdermal delivery of therapeutic agents. It also describes the in vitro and in vivo investigations reported for the various classes of therapeutic agents, along with the recent developments.


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