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Critical Reviews™ in Therapeutic Drug Carrier Systems

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Role of Immunostimulatory DNA and TLR9 in Gene Therapy

Volumen 23, Ausgabe 2, 2006, pp. 89-110
DOI: 10.1615/CritRevTherDrugCarrierSyst.v23.i2.10
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ABSTRAKT

One of the key issues of DNA-based therapies is the immunostimulatory effect caused by DNA, which it has a significant impact on the consequences of these therapies. This is a result of the recognition by Toll-like receptor-9 (TLR9); a pattern recognition receptor for unmethylated CpG motifs within DNA sequences. However, recent studies show that TLR9 can recognize non-CpG motifs and induce cellular activation when DNA is efficiently delivered to TLR9, for example, by cationic lipids. Moreover, recent research shows that TLR9−independent immunoactivation could take place. Here, we have attempted to present an overview of immunoactivation by DNA to optimize DNA-based therapies.

REFERENZIERT VON
  1. Yoshinaga Takaharu, Yasuda Kei, Ogawa Yoshiyuki, Nishikawa Makiya, Takakura Yoshinobu, DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells, Immunology, 120, 3, 2007. Crossref

  2. Ehlers Marc, Ravetch Jeffrey V., Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance, Trends in Immunology, 28, 2, 2007. Crossref

  3. Eschenburg Georg, Stermann Alexander, Preissner Robert, Meyer Hellmuth-Alexander, Lode Holger N., DNA Vaccination: Using the Patient's Immune System to Overcome Cancer, Clinical and Developmental Immunology, 2010, 2010. Crossref

  4. Nishikawa Makiya, Takakura Yoshinobu, Hashida Mitsuru, Pharmacokinetic considerations regarding non-viral cancer gene therapy, Cancer Science, 99, 5, 2008. Crossref

  5. Soderquist Ryan Gene, Sloane Evan M., Loram Lisa C., Harrison Jacqueline A., Dengler Ellen C., Johnson Scott M., Amer Luke D., Young Courtney S., Lewis Makenzie T., Poole Stephen, Frank Matthew G., Watkins Linda R., Milligan Erin D., Mahoney Melissa J., Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration, Pharmaceutical Research, 27, 5, 2010. Crossref

  6. Tu Sanfang, Zhong Danli, Xie Weixin, Huang Wenfa, Jiang Yangyang, Li Yuhua, Role of Toll-Like Receptor Signaling in the Pathogenesis of Graft-versus-Host Diseases, International Journal of Molecular Sciences, 17, 8, 2016. Crossref

  7. Rodet Franck, Capuz Alice, Hara Tsukasa, van Meel Rinaldo, Duhamel Marie, Rose Mélanie, Raffo-Romero Antonella, Fournier Isabelle, Salzet Michel, Deciphering molecular consequences of the proprotein convertase 1/3 inhibition in macrophages for application in anti-tumour immunotherapy, Journal of Biotechnology, 282, 2018. Crossref

  8. Putzke Simone, Feldhues Elisabeth, Heep Iris, Ilg Thomas, Lamprecht Alf, Cationic lipid/pDNA complex formation as potential generic method to generate specific IRF pathway stimulators, European Journal of Pharmaceutics and Biopharmaceutics, 155, 2020. Crossref

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