Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 0743-4863
ISSN Online: 2162-660X
Indexed in
Peroxisome Proliferated Activated Receptors (PPARs): Opportunities and Challenges for Ocular Therapy
ABSTRAKT
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors. They exist in three isoforms (PPAR-α, PPAR-β/δ, and PPAR-Υ) in humans, but mainly PPAR-Υ, and they are expressed in retinal epithelial pigment. PPARs are involved in mediating numerous pathological implications in eye such as diabetic retinopathy (DR), choroidal neovascularization (CNV), glaucoma, diabetic macular edema, and other retinal diseases. Peroxisome proliferator-activated receptors are key players in various biological pathways like lipid degeneration, immune regulation, and reactive oxygen species regulation, regulation of vascular endothelial growth factor, matrixmetalloproteinase-9, and docosahexaenoic acid pathway. Based on evidence from clinical investigations, the drugs meant for PPARs could be promising candidates for intraocular therapy. Anti-VEGF therapy, including bevacizumab, ranibizumab, and aptamers (pegaptanib), has been approved for wet age-related macular degeneration (ARMD). Recently, researchers have explored the role of PPAR-γ in ocular pathophysiological processes and PPAR-γ agonists as novel adjuvants in the treatment of eye diseases. PPAR-γ exhibits potential benefits to improve or prevent various vision-threatening eye diseases such as age-related macular degeneration (ARMD), diabetic retinopathy (DR), keratitis, and optic neuropathy. However, PPAR-γ presents challenges and offers opportunities for ocular scientists to bring better outcomes.
-
Qian Yu, Li Mingyue, Wang Wei, Wang Hongwei, Zhang Yu, Hu Qiang, Zhao Xin, Suo Huayi, Effects of Lactobacillus Casei YBJ02 on Lipid Metabolism in Hyperlipidemic Mice , Journal of Food Science, 84, 12, 2019. Crossref
-
Verma Amit, Sharma Gajanand, Jain Ankit, Tiwari Ankita, Saraf Shivani, Panda Pritish Kumar, Katare Om Prakash, Jain Sanjay K., Systematic optimization of cationic surface engineered mucoadhesive vesicles employing Design of Experiment (DoE): A preclinical investigation, International Journal of Biological Macromolecules, 133, 2019. Crossref
-
Qi Lei, Zhou Yu, Li Weijie, Zheng Mali, Zhong Ruisheng, Jin Xin, Lin Yuan, Effect of Moringa oleifera stem extract on hydrogen peroxide-induced opacity of cultured mouse lens, BMC Complementary and Alternative Medicine, 19, 1, 2019. Crossref
-
Gustafsson Jan-Ake, Strom Anders, Warner Margaret, Update on ERbeta, The Journal of Steroid Biochemistry and Molecular Biology, 191, 2019. Crossref
-
Fontaine Valérie, Fournié Mylène, Monteiro Elodie, Boumedine Thinhinane, Balducci Christine, Guibout Louis, Latil Mathilde, Sahel José-Alain, Veillet Stanislas, Dilda Pierre J., Lafont René, Camelo Serge, A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin, Aging, 13, 18, 2021. Crossref
-
Escandon Paulina, Vasini Brenda, Whelchel Amy E., Nicholas Sarah E., Matlock H. Greg, Ma Jian-Xing, Karamichos Dimitrios, The role of peroxisome proliferator-activated receptors in healthy and diseased eyes, Experimental Eye Research, 208, 2021. Crossref
-
Yu Peng, Wang Yang, Yang Wen-Tao, Li Zhi, Zhang Xiao-Juan, Zhou Li, Gui Jian-Fang, Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye, Science China Life Sciences, 64, 7, 2021. Crossref
-
Verma Amit, Jain Ankit, Tiwari Ankita, Saraf Shivani, Panda Pritish Kumar, Jain Sanjay K., Promising Antifungal Potential of Engineered Non-ionic Surfactant-Based Vesicles: In Vitro and In Vivo Studies, AAPS PharmSciTech, 22, 1, 2021. Crossref
-
Badria Farid A., Elgazar Abdullah A., Revealing the molecular mechanism of Olea europaea L. in treatment of cataract, in Olives and Olive Oil in Health and Disease Prevention, 2021. Crossref
-
Matlock H. Greg, Qiu Fangfang, Malechka Volha, Zhou Kelu, Cheng Rui, Benyajati Siribhinya, Whelchel Amy, Karamichos Dimitrios, Ma Jian-xing, Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes, Diabetes, 69, 6, 2020. Crossref
-
Feng Senling, Zhang Jing, Liang Baoying, Jin Hongliu, Yuan Zhongwen, Effects of cyclocarya paliurus flavonoid extract in non-alcoholic steatohepatitis mice: Intermeshing network pharmacology and in vivo pharmacological evaluation, Pharmacognosy Magazine, 17, 76, 2021. Crossref
-
Santana-Garrido Álvaro, Reyes-Goya Claudia, Arroyo-Barrios Ana, André Helder, Vázquez Carmen M., Mate Alfonso, Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice, Journal of Physiology and Biochemistry, 2022. Crossref
-
Fabre Marie, Mateo Lou, Lamaa Diana, Baillif Stéphanie, Pagès Gilles, Demange Luc, Ronco Cyril, Benhida Rachid, Recent Advances in Age-Related Macular Degeneration Therapies, Molecules, 27, 16, 2022. Crossref
-
Sinclair Stephen H., Miller Elan, Talekar Kiran S., Schwartz Stanley S., Diabetes mellitus associated neurovascular lesions in the retina and brain: A review, Frontiers in Ophthalmology, 2, 2022. Crossref
-
Alaswad Saleh O., Mahmoud Amira S., Arunachalam Prabhakarn, Recent Advances in Biodegradable Polymers and Their Biological Applications: A Brief Review, Polymers, 14, 22, 2022. Crossref