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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
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Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens
ABSTRAKT
Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors such as the estrogen receptor and the androgen receptor and several other transcription factors to enhance their effects on target gene expression. SRC-3 plays important roles in many developmental, physiological, and pathologic events, including body growth, mammary gland development, energy homeostasis, inflammatory regulation, and cancer initiation and progression. SRC-3 has been suggested to be involved in host defense against bacterial pathogens. In this review, we summarize the roles of SRC-3 in host defense against peritoneal and enteric bacterial infection and discuss the potential clinical implications.
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Ma Yanni, Qi Qi, He Qingping, Gilyazova Nailya S., Ibeanu Gordon, Li P. Andy, Neuroprotection by B355252 against Glutamate-Induced Cytotoxicity in Murine Hippocampal HT-22 Cells Is Associated with Activation of ERK3 Signaling Pathway, Biological and Pharmaceutical Bulletin, 44, 11, 2021. Crossref