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Critical Reviews™ in Immunology
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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017024718
pages 15-21

Roles of Dectin-1 in Allergic Airway Inflammation

Koichi Hirose
Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Rheumatology, School of Medicine, International University of Health and Welfare, Chiba, Japan
Takashi Ito
Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
Hiroshi Nakajima
Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan

ABSTRAKT

Asthma is a chronic allergic inflammatory disease of the airways. The symptoms can be controlled by inhaled corticosteroids together with long-acting β2 agonists in the majority of patients; however, in some patients, their symptoms remain uncontrolled even under intensive treatment. Although underlying mechanisms of the heterogeneous responses to the treatment are largely unknown, a series of recent epidemiological studies have suggested a link between the severity of asthma and the sensitization to fungi. Dectin-1, a C-type lectin receptor expressed on myeloid cells and plays protective roles against fungi by recognizing a cell-wall component of fungi, has recently been suggested to be involved in the development of severe asthma. In this review, we summarize the roles of Dectin-1 in the pathogenesis of severe asthma and discuss the possibility of its therapeutic application.


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