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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
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The Role of Bruton's Tyrosine Kinase in Immune Cell Signaling and Systemic Autoimmunity
ABSTRAKT
Bruton's tyrosine kinase (BTK) is an intracellular signaling molecule first identified as the molecule affected in X-linked agammaglobulinemia (XLA) patients, who almost completely lack peripheral B cells and serum immunoglobulins. BTK is crucial for B cell development and various B cell functions, including cytokine and natural antibody production. Importantly, it is also expressed in numerous other cells, including monocytes, macrophages, granulocytes, dendritic cells, and osteoclasts. A few rare cases of autoimmune disease in XLA patients have been described. Interestingly, increased BTK protein expression in patients with systemic autoimmune disease appears to be correlated with autoantibody production. In addition, BTK may promote autoimmunity as an important driver of an imbalance in B-T cell interaction. Because of this overwhelming evidence of a pathogenic role of BTK in autoimmunity, several clinical trials in rheumatoid arthritis and systemic lupus erythematosus patients with BTK inhibitors are currently running. Here, we review BTK function in different signaling pathways and in different cell lineages, focusing on the growing body of literature indicating a critical role for BTK in autoimmunity. We also discuss BTK and the promising results of BTK inhibition in animal models of autoimmune disease.
-
Saghazadeh Amene, Rezaei Nima, Pulmonary Manifestations of Predominantly Antibody Deficiencies, in Pulmonary Manifestations of Primary Immunodeficiency Diseases, 2019. Crossref
-
von Borstel Anouk, Abdulahad Wayel H, Sanders Jan Stephan, Rip Jasper, Neys Stefan F H, Hendriks Rudi W, Stegeman Coen A, Heeringa Peter, Rutgers Abraham, Corneth Odilia B J, Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis, Rheumatology, 58, 12, 2019. Crossref
-
Rip Jasper, de Bruijn Marjolein J. W., Appelman Marjolein K., Pal Singh Simar, Hendriks Rudi W., Corneth Odilia B. J., Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease, Frontiers in Immunology, 10, 2019. Crossref
-
Eades Christopher P, Armstrong-James Darius P H, Invasive fungal infections in the immunocompromised host: Mechanistic insights in an era of changing immunotherapeutics, Medical Mycology, 57, Supplement_3, 2019. Crossref
-
Jeong Sukyo, Sohn Yoo-Kyoung, Choi Yoonjoo, Park Jinho, Kim Hak-Sung, A regulatory SH2 domain-targeting protein binder effectively inhibits the activity of Bruton’s tyrosine kinase and its drug-resistant variants, Biochemical and Biophysical Research Communications, 526, 1, 2020. Crossref
-
Posch Wilfried, Wilflingseder Doris, Lass-Flörl Cornelia, Immunotherapy as an Antifungal Strategy in Immune Compromised Hosts, Current Clinical Microbiology Reports, 7, 3, 2020. Crossref
-
Al-Harbi Naif O., Nadeem Ahmed, Ahmad Sheikh F., Bakheet Saleh A., El-Sherbeeny Ahmad M., Ibrahim Khalid E., Alzahrani Khalid S., Al-Harbi Mohammed M., Mahmood Hafiz M., Alqahtani Faleh, Attia Sabry M., Alotaibi Moureq R., Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells, European Journal of Pharmacology, 877, 2020. Crossref
-
Rip Jasper, de Bruijn Marjolein J. W., Kaptein Allard, Hendriks Rudi W., Corneth Odilia B. J., Phosphoflow Protocol for Signaling Studies in Human and Murine B Cell Subpopulations, The Journal of Immunology, 204, 10, 2020. Crossref
-
Nadeem Ahmed, Ahmad Sheikh F., Al-Harbi Naif O., El-Sherbeeny Ahmad M., Alasmari Abullah F, Alanazi Wael A., Alasmari Fawaz, Ibrahim Khalid E., Al-Harbi Mohammed M., Bakheet Saleh A, Attia Sabry M., Bruton’s tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells, International Immunopharmacology, 80, 2020. Crossref
-
Sims Matthew C., Mayer Louisa, Collins Janine H., Bariana Tadbir K., Megy Karyn, Lavenu-Bombled Cecile, Seyres Denis, Kollipara Laxmikanth, Burden Frances S., Greene Daniel, Lee Dave, Rodriguez-Romera Antonio, Alessi Marie-Christine, Astle William J., Bahou Wadie F., Bury Loredana, Chalmers Elizabeth, Da Silva Rachael, De Candia Erica, Deevi Sri V. V., Farrow Samantha, Gomez Keith, Grassi Luigi, Greinacher Andreas, Gresele Paolo, Hart Dan, Hurtaud Marie-Françoise, Kelly Anne M., Kerr Ron, Le Quellec Sandra, Leblanc Thierry, Leinøe Eva B., Mapeta Rutendo, McKinney Harriet, Michelson Alan D., Morais Sara, Nugent Diane, Papadia Sofia, Park Soo J., Pasi John, Podda Gian Marco, Poon Man-Chiu, Reed Rachel, Sekhar Mallika, Shalev Hanna, Sivapalaratnam Suthesh, Steinberg-Shemer Orna, Stephens Jonathan C., Tait Robert C., Turro Ernest, Wu John K. M., Zieger Barbara, Kuijpers Taco W., Whetton Anthony D., Sickmann Albert, Freson Kathleen, Downes Kate, Erber Wendy N., Frontini Mattia, Nurden Paquita, Ouwehand Willem H., Favier Remi, Guerrero Jose A., Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome, Blood, 136, 17, 2020. Crossref
-
Cohen Stanley, Tuckwell Katie, Katsumoto Tamiko R., Zhao Rui, Galanter Joshua, Lee Chin, Rae Julie, Toth Balazs, Ramamoorthi Nandhini, Hackney Jason A., Berman Alberto, Damjanov Nemanja, Fedkov Dmytro, Jeka Slawomir, Chinn Leslie W., Townsend Michael J., Morimoto Alyssa M., Genovese Mark C., Berman Alberto, Porto Alejandro, Granel Amelia, Asnal Cecilia, Mysler Eduardo Fabian, Testa Gladys Alicia, Zamora Jose Luis Velasco, Moreno Jose Luis Cristian, Gulin Juan Pablo, Hofman Julio, Ulla Maria Rosa, Sabelli Mirtha, Mannucci Pablo Alejandro, Maid Pablo Jorge, Melazzi Ana Cláudia Cauceglia, Scotton Antônio Scafuto, Ximenes Antônio Carlos, Funes Elisete, Gimenez Emerson Alves, Marcolino Flora Maria D’Andrea, Neto João Francisco Marques, Keiserman Mauro Waldemar, Radominski Sebastião Cézar, Lima Sônia Maria Alvarenga Anti Loduca, Pavan Thaís Rohde, Azevedo Valderílio Feijó, Koleva Aneliya, Toncheva Antoaneta, Bichovska Daniela, Ivanova Delina, Penev Dimitar, Dimitrov Emil, Mihaylova Mariyana, Kapandjieva Nadezhda, Marinova Natalia, Aleksieva Tanya, Tsvetanova Tanya, Petranova Tsvetanka, Popova Valentina, Spasov Yuliy, Toro Carlos Enrique, Arteaga Unigarro Carlos Ernesto, Jauregui Edwin, Hernandez Javier Dario Marquez, Raad Juan Jose Jaller, Sanchez Patricia Julieta Velez, Lee Chang Keun, Suh Chang‐Hee, Lee Eun Young, Lee Sang‐Heon, Kang Seong Wook, Lee Shin‐Seok, Lee Yun Jong, Montiel Beatriz Elena Zazueta, Pinzon de la O Blanca Irma, Friedmann Daniel Xibille, Lopez Francisco Rosas, Torres Isaura Rodriguez, Quezada Luis Jara, Ceceña Marco Maradiaga, Hernandez Miguel Cortes, Salinas Miguel Saavedra, Rapa Agnieszka, Pawtel Agnieszka, Zielinska Agnieszka, Dudek Anna, Rychlewska‐Hanczewska Anna, Strzelecka Anna, Racewicz Artur, Stasiuk Barbara, Gruszecka Katarzyna, Dworak Krystyna, Jeka Slawomir, Lowenhoff Tomasz, Maslyanskiy Alexey, Rebrov Andrey, Krechikova Diana, Zhugrova Elena, Shmidt Evgeniya, Matsievskaya Galina, Vinogradova Irina, Ler Irina, Eliseeva Larisa, Savina Ludmila, Stanislav Marina, Sandin Mikhail, Zyablova Natalia, Korshunov Nikolay, Mosesova Nino, Polovnikova Oksana, Nesmeyanova Olga, Samigullina Ruzana, Moiseev Sergey, Noskov Sergey, Raskina Tatiana, Popova Tatiana, Marchenko Valeriy, Jovanovski Aleksandar, Stamenkovic Bojana, Ristic Gorica, Lazarevic Milijanka, Veselinovic Mirjana, Vujasinovic‐Stupar Nada, Damjanov Nemanja, Ostojic Predrag, Yagensky Andriy, Gnylorybov Andriy, Rekalov Dmytro, Reshotko Dmytroo, Fedkov Dmytro, Dzyak Georgiy, Gasanov Iurii, Khimion Ludmila, Stanislavchuk Mykola, Prykhodko Natalya, Nadashkevych Oleg, Bortkevych Oleg, Abrahamovych Orest, Yatsyshyn Roman, Turyanytsya Samvel, Smiyan Svitlana, Vizir Vadym, Kachur Victoria, Tseluyko Vira, Povoroznyuk Vladyslav, Koshlia Volodymyr, Zhdan Vyacheslav, Lymar Yurii, Mostovoy Yuriy, Hawkes Angela, Mabaquiao Arthur, Chu Cong‐Qiu, Scoville Craig, Wyatt David, Weinstein Debra, McIlwain Harris, Vo Jacqueline, Poiley Jeffrey, Forstot Joseph, Dao Kathryn, Turner Mark, Genovese Mark, Borofsky Michael, Caldron Paul, Waller Philip, Levin Robert, Metyas Samy, Stein Scott, Shroff Sharukh, Pang Shirley, Cohen Stanley, Syed Tauseef, Chindalore Vishala, Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double‐Blind, Phase II Trial , Arthritis & Rheumatology, 72, 9, 2020. Crossref
-
Wang Bin, Chen Shiju, Li Yan, Xuan Jingxiu, Liu Yuan, Shi Guixiu, Targeted Therapy for Primary Sjögren’s Syndrome: Where are We Now?, BioDrugs, 35, 6, 2021. Crossref
-
Zhu Sining, Gokhale Samantha, Jung Jaeyong, Spirollari Eris, Tsai Jemmie, Arceo Johann, Wu Ben Wang, Victor Eton, Xie Ping, Multifaceted Immunomodulatory Effects of the BTK Inhibitors Ibrutinib and Acalabrutinib on Different Immune Cell Subsets – Beyond B Lymphocytes, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref
-
Vinogradova Ekaterina V., Zhang Xiaoyu, Remillard David, Lazar Daniel C., Suciu Radu M., Wang Yujia, Bianco Giulia, Yamashita Yu, Crowley Vincent M., Schafroth Michael A., Yokoyama Minoru, Konrad David B., Lum Kenneth M., Simon Gabriel M., Kemper Esther K., Lazear Michael R., Yin Sifei, Blewett Megan M., Dix Melissa M., Nguyen Nhan, Shokhirev Maxim N., Chin Emily N., Lairson Luke L., Melillo Bruno, Schreiber Stuart L., Forli Stefano, Teijaro John R., Cravatt Benjamin F., An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells, Cell, 182, 4, 2020. Crossref
-
Zhu Sining, Jung Jaeyong, Victor Eton, Arceo Johann, Gokhale Samantha, Xie Ping, Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Malignancies, Frontiers in Oncology, 11, 2021. Crossref
-
Langrish Claire L., Bradshaw J. Michael, Francesco Michelle R., Owens Timothy D., Xing Yan, Shu Jin, LaStant Jacob, Bisconte Angelina, Outerbridge Catherine, White Stephen D., Hill Ronald J., Brameld Ken A., Goldstein David M., Nunn Philip A., Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease, The Journal of Immunology, 206, 7, 2021. Crossref
-
Cencioni Maria T., Mattoscio Miriam, Magliozzi Roberta, Bar-Or Amit, Muraro Paolo A., B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies, Nature Reviews Neurology, 17, 7, 2021. Crossref
-
Glembotsky Ana C, De Luca Geraldine, Heller Paula G, A Deep Dive into the Pathology of Gray Platelet Syndrome: New Insights on Immune Dysregulation, Journal of Blood Medicine, Volume 12, 2021. Crossref
-
Jepson Tyler A., Chung Jean K., Diffusion-based determination of protein homodimerization on reconstituted membrane surfaces, BMB Reports, 54, 3, 2021. Crossref
-
Rip Jasper, Bruijn Marjolein J. W., Neys Stefan F. H., Singh Simar Pal, Willar Jonas, Hulst Jennifer A. C., Hendriks Rudi W., Corneth Odilia B. J., Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B‐cell receptor signaling in mice, European Journal of Immunology, 51, 9, 2021. Crossref
-
Zheng Jiamin, Wu Jun, Ding Xiao, Shen Hong C., Zou Ge, Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 38, 2021. Crossref
-
García-Merino Antonio, Bruton’s Tyrosine Kinase Inhibitors: A New Generation of Promising Agents for Multiple Sclerosis Therapy, Cells, 10, 10, 2021. Crossref
-
Murrell D.F., Patsatsi A., Stavropoulos P., Baum S., Zeeli T., Kern J.S., Roussaki‐Schulze A.‐V., Sinclair R., Bassukas I.D., Thomas D., Neale A., Arora P., Caux F., Werth V.P., Gourlay S.G., Joly P., Proof of concept for the clinical effects of oral rilzabrutinib, the first Bruton tyrosine kinase inhibitor for pemphigus vulgaris: the phase II BELIEVE study*, British Journal of Dermatology, 185, 4, 2021. Crossref
-
Xie Zhouling, Yang Xiaoxiao, Duan Yajun, Han Jihong, Liao Chenzhong, Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases, Journal of Medicinal Chemistry, 64, 3, 2021. Crossref
-
Li Shuang, Su Jin, Cai Wei, Liu Jian-xin, Nanomaterials Manipulate Macrophages for Rheumatoid Arthritis Treatment, Frontiers in Pharmacology, 12, 2021. Crossref
-
Bonasia Carlo G., Abdulahad Wayel H., Rutgers Abraham, Heeringa Peter, Bos Nicolaas A., B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells, Cells, 10, 5, 2021. Crossref
-
Neys Stefan F. H., Rip Jasper, Hendriks Rudi W., Corneth Odilia B. J., Bruton’s Tyrosine Kinase Inhibition as an Emerging Therapy in Systemic Autoimmune Disease, Drugs, 81, 14, 2021. Crossref
-
Weber Martin S., Nicholas Jacqueline A., Yeaman Michael R., Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic, Neurology - Neuroimmunology Neuroinflammation, 8, 6, 2021. Crossref
-
Jacobs Chaja F., Eldering Eric, Kater Arnon P., Kinase inhibitors developed for treatment of hematologic malignancies: implications for immune modulation in COVID-19, Blood Advances, 5, 3, 2021. Crossref
-
Neys Stefan F. H., Hendriks Rudi W., Corneth Odilia B. J., Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref
-
Bacalao Maria A., Satterthwaite Anne B., Recent Advances in Lupus B Cell Biology: PI3K, IFNγ, and Chromatin, Frontiers in Immunology, 11, 2021. Crossref
-
Mihalovits Levente M., Ferenczy György G., Keserű György M., Affinity and Selectivity Assessment of Covalent Inhibitors by Free Energy Calculations, Journal of Chemical Information and Modeling, 60, 12, 2020. Crossref
-
Li Shao-Yan, Wang Yan, Wang Li-Hua, Chronic lymphocytic leukemia/small lymphocytic lymphoma complicated with skin Langerhans cell sarcoma: A case report , World Journal of Clinical Cases, 9, 34, 2021. Crossref
-
Tichenor Mark S., Wiener John J. M., Rao Navin L., Pooley Deckhut Charlotte, Barbay J. Kent, Kreutter Kevin D., Bacani Genesis M., Wei Jianmei, Chang Leon, Murrey Heather E., Wang Weixue, Ahn Kay, Huber Michael, Rex Elizabeth, Coe Kevin J., Wu JieJun, Seierstad Mark, Bembenek Scott D., Leonard Kristi A., Lebsack Alec D., Venable Jennifer D., Edwards James P., Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity, ACS Medicinal Chemistry Letters, 12, 5, 2021. Crossref
-
Boccarelli Angelina, Del Buono Nicoletta, Esposito Flavia, Analysis of fibroblast genes selected by NMF to reveal the potential crosstalk between ulcerative colitis and colorectal cancer, Experimental and Molecular Pathology, 123, 2021. Crossref
-
Xiao Zhengrui, Murakhovskaya Irina, Development of New Drugs for Autoimmune Hemolytic Anemia, Pharmaceutics, 14, 5, 2022. Crossref
-
Wan Jia, Yu Xi, Niu Jia-Qi, Qiu Le, Wang Fei, Chen Xu-Lin, Inhibition of Bruton's Tyrosine Kinase Protects Against Burn Sepsis-Induced Intestinal Injury, Frontiers in Medicine, 9, 2022. Crossref
-
Bonami Rachel H., Thurman Christina E., Verma Sonam, Westlake Camille S., Nyhoff Lindsay E., Barron Bridgette B., Reboldi Andrea, Kendall Peggy L., Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis, Frontiers in Immunology, 13, 2022. Crossref
-
Liu Zhe, De Porto Alexander P.N.A., De Beer Regina, Roelofs Joris J.T.H., De Boer Onno J., Florquin Sandrine, Van’t Veer Cornelis, Hendriks Rudi W., Van der Poll Tom, De Vos Alex F., Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against <b><i>Klebsiella pneumoniae</i></b>, Journal of Innate Immunity, 2022. Crossref
-
Yong Heather Y. F., Yong V. Wee, Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis, Nature Reviews Neurology, 18, 1, 2022. Crossref
-
Steinmaurer Anja, Wimmer Isabella, Berger Thomas, Rommer Paulus S, Sellner Johann, Bruton's Tyrosine Kinase Inhibition in the Treatment of Preclinical Models and Multiple Sclerosis, Current Pharmaceutical Design, 28, 6, 2022. Crossref
-
Ucpinar Sibel, Darpo Borje, Neale Ann, Nunn Philip, Shu Jin, Chu Katherine A., Kavanagh Marianne, Xue Hongqi, Phiasivongsa Pasit, Thomas Dolca, Smith Patrick F., A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects , Clinical and Translational Science, 15, 6, 2022. Crossref
-
Liu Zhe, van ‘t Veer Cornelis, Hendriks Rudi W., Roelofs Joris J. T. H., van der Poll Tom, de Vos Alex F., Raffatellu Manuela, Bruton’s Tyrosine Kinase Deficiency Ameliorates Antimicrobial Host Defense during Peritonitis Induced by Pathogenic Escherichia coli, Infection and Immunity, 90, 6, 2022. Crossref
-
Zhang Xin, Zhang Liangliang, Xia Kaide, Dai Jie, Huang Jiangtao, Wang Yun, Zhu Guiming, Hu Zuquan, Zeng Zhu, Jia Yi, Effects of dietary selenium on immune function of spleen in mice, Journal of Functional Foods, 89, 2022. Crossref
-
Chung Jean K., Nocka Laura M., Decker Aubrianna, Wang Qi, Kadlecek Theresa A., Weiss Arthur, Kuriyan John, Groves Jay T., Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization, Proceedings of the National Academy of Sciences, 116, 22, 2019. Crossref
-
Owens Timothy D., Brameld Ken A., Verner Erik J., Ton Tony, Li Xiaoyan, Zhu Jiang, Masjedizadeh Mohammad R., Bradshaw J. Michael, Hill Ronald J., Tam Danny, Bisconte Angelina, Kim Eun Ok, Francesco Michelle, Xing Yan, Shu Jin, Karr Dane, LaStant Jacob, Finkle David, Loewenstein Natalie, Haberstock-Debic Helena, Taylor Michael J., Nunn Philip, Langrish Claire L., Goldstein David M., Discovery of Reversible Covalent Bruton’s Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib), Journal of Medicinal Chemistry, 65, 7, 2022. Crossref
-
Yu Chen Guang, Bondada Vimala, Iqbal Hina, Moore Kate L., Gensel John C., Bondada Subbarao, Geddes James W., Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury, International Journal of Molecular Sciences, 23, 1, 2021. Crossref
-
Airas Laura, Yong V. Wee, Microglia in multiple sclerosis – pathogenesis and imaging, Current Opinion in Neurology, 35, 3, 2022. Crossref
-
Mendes‐Bastos Pedro, Brasileiro Ana, Kolkhir Pavel, Frischbutter Stefan, Scheffel Jörg, Moñino‐Romero Sherezade, Maurer Marcus, Bruton's tyrosine kinase inhibition—An emerging therapeutic strategy in immune‐mediated dermatological conditions, Allergy, 77, 8, 2022. Crossref
-
Yong V. Wee, Microglia in multiple sclerosis: Protectors turn destroyers, Neuron, 2022. Crossref
-
Giardino Giuliana, Cirillo Emilia, Prencipe Rosaria, Romano Roberta, Cillo Francesca, Toriello Elisabetta, De Rosa Veronica, Pignata Claudio, Mechanisms of immune tolerance breakdown in inborn errors of immunity, in Translational Autoimmunity, 2022. Crossref
-
Nasra Simran, Bhatia Dhiraj, Kumar Ashutosh, Recent advances in nanoparticle-based drug delivery systems for rheumatoid arthritis treatment, Nanoscale Advances, 4, 17, 2022. Crossref
-
Minguet Susana, Nyström Alexander, Kiritsi Dimitra, Rizzi Marta, Inborn errors of immunity and immunodeficiencies: Antibody‐mediated pathology and autoimmunity as a consequence of impaired immune reactions, European Journal of Immunology, 52, 9, 2022. Crossref
-
Carnero Contentti Edgar, Correale Jorge, Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis, Drug Design, Development and Therapy, Volume 16, 2022. Crossref
-
Corneth Odilia B. J., Neys Stefan F. H., Hendriks Rudi W., Aberrant B Cell Signaling in Autoimmune Diseases, Cells, 11, 21, 2022. Crossref