Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
Indexed in
Mechanisms and Mediators of Pulmonary Fibrosis
ABSTRAKT
The mechanisms of pulmonary fibrosis are complex, and several hypotheses have been put forward to explain how fibrosis develops. It was long thought that inflammation was a key event in the process; however, this has recently been challenged. The inflammation hypothesis has led to the description of numerous inflammatory and profibrotic mediators in the pathogenesis of fibrosis. Inhibition of inflammation can attenuate fibrosis in animal models but is less successful in humans. More recently, an important role for epithelial injury, circulating mesenchymal precursor cells, epithelial-to-mesenchymal transition, and vascular remodeling have been described in various models of fibrosis. Many of the classic inflammatory and profibrotic mediators are important in these processes, as well. The development of effective therapies will require the understanding of the complex interplay of the various mediators and the mechanisms of remodeling.
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Jin Gong Yong, Bok Se Mi, Han Young Min, Chung Myung Ja, Yoon Kwon-Ha, Kim So Ri, Lee Yong Chul, Effectiveness of rosiglitazone on bleomycin-induced lung fibrosis: Assessed by micro-computed tomography and pathologic scores, European Journal of Radiology, 81, 8, 2012. Crossref
-
Omary M. Bishr, Lugea Aurelia, Lowe Anson W., Pandol Stephen J., The pancreatic stellate cell: a star on the rise in pancreatic diseases, Journal of Clinical Investigation, 117, 1, 2007. Crossref
-
PAN Jin Bing, HOU Yu Hong, ZHANG Guo Jun, Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats, Respirology, 14, 7, 2009. Crossref
-
Fix Charity, Bingham Kellie, Carver Wayne, Effects of interleukin-18 on cardiac fibroblast function and gene expression, Cytokine, 53, 1, 2011. Crossref
-
Mori Ryoichi, Shaw Tanya J., Martin Paul, Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring, Journal of Experimental Medicine, 205, 1, 2008. Crossref
-
Molina-Molina María, Pereda Javier, Xaubet Antoni, Experimental Models for the Study of Pulmonary Fibrosis: Current Usefulness and Future Promise, Archivos de Bronconeumología ((English Edition)), 43, 9, 2007. Crossref
-
Kolonin Mikhail G., Evans Kurt W., Mani Sendurai A., Gomer Richard H., Alternative origins of stroma in normal organs and disease, Stem Cell Research, 8, 2, 2012. Crossref
-
Molina-Molina María, Pereda Javier, Xaubet Antoni, Modelos experimentales para el estudio de la fibrosis pulmonar: utilidad práctica actual y futura, Archivos de Bronconeumología, 43, 9, 2007. Crossref
-
Mangoni Monica, Sottili Mariangela, Gerini Chiara, Bonomo Pierluigi, Bottoncetti Anna, Castiglione Francesca, Franzese Ciro, Cassani Sara, Greto Daniela, Masoni Tatiana, Meattini Icro, Pallotta Stefania, Passeri Alessandro, Pupi Alberto, Vanzi Eleonora, Biti Giampaolo, Livi Lorenzo, A PPAR-gamma agonist attenuates pulmonary injury induced by irradiation in a murine model, Lung Cancer, 90, 3, 2015. Crossref
-
Caldwell Charles C., Chen Yi, Goetzmann Holly S., Hao Yonghua, Borchers Michael T., Hassett Daniel J., Young Lisa R., Mavrodi Dmitri, Thomashow Linda, Lau Gee W., Pseudomonas aeruginosa Exotoxin Pyocyanin Causes Cystic Fibrosis Airway Pathogenesis, The American Journal of Pathology, 175, 6, 2009. Crossref
-
Yao Rong, He Yarong, Zeng Zhi, Liang Zongan, Cao Yu, Protective effect of adiponectin on paraquat-induced pulmonary fibrosis in mice, Molecular & Cellular Toxicology, 11, 2, 2015. Crossref
-
Hagiwara Satoshi, Iwasaka Hideo, Matsumoto Shigekiyo, Noguchi Takayuki, Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats, Respiratory Research, 8, 1, 2007. Crossref
-
You Jia, Wang Jintao, Xie Linshen, Zhu Chengwen, Xiong Jingyuan, D-4F, an apolipoprotein A-I mimetic, inhibits TGF-β1 induced epithelial-mesenchymal transition in human alveolar epithelial cell, Experimental and Toxicologic Pathology, 68, 9, 2016. Crossref
-
Song Cheng, He Lujuan, Zhang Jin, Ma Hong, Yuan Xiangning, Hu Gaoyun, Tao Lijian, Zhang Jian, Meng Jie, Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP 3 inflammasome and IL ‐1β/ IL ‐1R1/MyD88/ NF ‐κB pathway , Journal of Cellular and Molecular Medicine, 20, 11, 2016. Crossref
-
Moore Bethany B., Hogaboam Cory M., Murine models of pulmonary fibrosis, American Journal of Physiology-Lung Cellular and Molecular Physiology, 294, 2, 2008. Crossref
-
Lim Jin Hong, Park Joon Seong, Yoon Dong Sup, Preoperative fecal elastase-1 is a useful prognostic marker following curative resection of pancreatic cancer, HPB, 19, 5, 2017. Crossref
-
Saito Yukihiro, Development of Gene Therapy for Lymphedema, The Japanese Journal of Phlebology, 28, 3, 2017. Crossref
-
Milam Jami E., Keshamouni Venkateshwar G., Phan Sem H., Hu Biao, Gangireddy Srinivasa R., Hogaboam Cory M., Standiford Theodore J., Thannickal Victor J., Reddy Raju C., PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis, American Journal of Physiology-Lung Cellular and Molecular Physiology, 294, 5, 2008. Crossref
-
Smith Monica R., Gangireddy Srinivasa R., Narala Venkata R., Hogaboam Cory M., Standiford Theodore J., Christensen Paul J., Kondapi Anand K., Reddy Raju C., Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury, American Journal of Physiology-Lung Cellular and Molecular Physiology, 298, 5, 2010. Crossref
-
Zhan Tian-Wei, Tian Yu-Xin, Wang Qi, Wu Zi-Xiang, Zhang Wei-Ping, Lu Yun-Bi, Wu Ming, Cangrelor alleviates pulmonary fibrosis by inhibiting GPR17-mediated inflammation in mice, International Immunopharmacology, 62, 2018. Crossref
-
Xue Ran, Jia Kai, Wang Jianxin, Yang Lixin, Wang Yanbin, Gao Lingyun, Hao Jianyu, A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells, Frontiers in Physiology, 9, 2018. Crossref
-
Ireland Lucy V., Mielgo Ainhoa, Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance, Frontiers in Cell and Developmental Biology, 6, 2018. Crossref
-
Matsuzawa Yasuo, Kawashima Tatsuo, Yamazaki Risa, Yamaura Erika, Makiyama Tomohiko, Fujino Hiromichi, Murayama Toshihiko, Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-.BETA.1-induced expression of .ALPHA.-smooth muscle actin in human fetal lung fibroblasts, The Journal of Toxicological Sciences, 36, 6, 2011. Crossref
-
Ohbayashi Masayuki, Suzuki Masanori, Yashiro Yoshiki, Fukuwaka Sayaka, Yasuda Masako, Kohyama Noriko, Kobayashi Yasuna, Yamamoto Toshinori, Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro, The Journal of Toxicological Sciences, 35, 5, 2010. Crossref
-
Ryffel Bernhard, Togbe Dieudonnée, Couillin Isabelle, Inflammasome and Lung Pathologies, in The Inflammasomes, 2011. Crossref
-
Venkatesan Narayanan, Punithavathi Durairaj, Babu Mary, PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref
-
Simonian Philip L., Roark Christina L., Diaz del Valle Fernando, Palmer Brent E., Douglas Ivor S., Ikuta Koichi, Born Willi K., O’Brien Rebecca L., Fontenot Andrew P., Regulatory Role of γδ T Cells in the Recruitment of CD4+and CD8+T Cells to Lung and Subsequent Pulmonary Fibrosis, The Journal of Immunology, 177, 7, 2006. Crossref
-
Gasse Pamela, Mary Caroline, Guenon Isabelle, Noulin Nicolas, Charron Sabine, Schnyder-Candrian Silvia, Schnyder Bruno, Akira Shizuo, Quesniaux Valérie F.J., Lagente Vincent, Ryffel Bernhard, Couillin Isabelle, IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice, Journal of Clinical Investigation, 2007. Crossref
-
Farran Batoul, Nagaraju Ganji Purnachandra, The dynamic interactions between the stroma, pancreatic stellate cells and pancreatic tumor development: Novel therapeutic targets, Cytokine & Growth Factor Reviews, 48, 2019. Crossref
-
Zhan Tianwei, Wei Taofeng, Dong Lingjun, Wang Qi, Wu Zixiang, Yan Qihang, Zhang Weiping, Lu Yunbi, Wu Ming, Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice, Molecular Immunology, 120, 2020. Crossref
-
Jiang Linxia, Wang Jianhong, Ju Jiarui, Dai Jundong, Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process, European Journal of Pharmacology, 883, 2020. Crossref
-
Kang Yun Pyo, Lee Sae Bom, Lee Ji-min, Kim Hyung Min, Hong Ji Yeon, Lee Won Jun, Choi Chang Woo, Shin Hwa Kyun, Kim Do-Jin, Koh Eun Suk, Park Choon-Sik, Kwon Sung Won, Park Sung-Woo, Metabolic Profiling Regarding Pathogenesis of Idiopathic Pulmonary Fibrosis, Journal of Proteome Research, 15, 5, 2016. Crossref
-
Card Jeffrey W., Voltz James W., Carey Michelle A., Bradbury J. Alyce, DeGraff Laura M., Lih Fred B., Bonner James C., Morgan Daniel L., Flake Gordon P., Zeldin Darryl C., Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 37, 3, 2007. Crossref
-
Bantsimba-Malanda Claudie, Marchal-Sommé Joëlle, Goven Delphine, Freynet Olivia, Michel Laurence, Crestani Bruno, Soler Paul, A Role for Dendritic Cells in Bleomycin-induced Pulmonary Fibrosis in Mice?, American Journal of Respiratory and Critical Care Medicine, 182, 3, 2010. Crossref
-
Kim Tae Hoon, Lee Yoo Hoon, Kim Kyung Hun, Lee Shin Hwa, Cha Ji Yeon, Shin Eun Kyoung, Jung Seok, Jang An Soo, Park Sung Woo, Uh Soo Taek, Kim Young Hoon, Park Jai Soung, Sin Hwa Gyoun, Youm Wook, Koh Eun Suk, Cho Sun Young, Paik Young Ki, Rhim Tai Youn, Park Choon Sik, Role of Lung Apolipoprotein A-I in Idiopathic Pulmonary Fibrosis, American Journal of Respiratory and Critical Care Medicine, 182, 5, 2010. Crossref
-
Pulichino Anne-Marie, Wang I-Ming, Caron Alexandre, Mortimer James, Auger Anick, Boie Yves, Elias Jack A., Kartono Aileen, Xu Lijing, Menetski Joseph, Sayegh Camil E., Identification of Transforming Growth Factor β1–Driven Genetic Programs of Acute Lung Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 39, 3, 2008. Crossref
-
Marchal-Sommé Joëlle, Uzunhan Yurdagul, Marchand-Adam Sylvain, Kambouchner Marianne, Valeyre Dominique, Crestani Bruno, Soler Paul, Dendritic Cells Accumulate in Human Fibrotic Interstitial Lung Disease, American Journal of Respiratory and Critical Care Medicine, 176, 10, 2007. Crossref
-
Venkatesan Narayanan, Tsuchiya Kimitake, Kolb Martin, Farkas Laszlo, Bourhim Mustapha, Ouzzine Mohamed, Ludwig Mara S., Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1–Induced Pulmonary Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 50, 3, 2014. Crossref
-
Daniels Craig E., Lasky Joseph A., Limper Andrew H., Mieras Kathleen, Gabor Edith, Schroeder Darrell R., Imatinib Treatment for Idiopathic Pulmonary Fibrosis, American Journal of Respiratory and Critical Care Medicine, 181, 6, 2010. Crossref