Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i6.10
pages 475-486

Regulation of Thymocyte Survival by Transcriptional Coactivators

Huimin Xie
Department of Microbiology & Immunology, College of Medicine, University of Illinois, Chicago, IL
Zhaofeng Huang
Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080 P.R. China
Ruiqing Wang
Division of Immunology, Beckman Research Institute of the City of Hope; Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA 91010
Zuoming Sun
City of Hope

ABSTRAKT

A majority of the developing T cells are eliminated by apoptosis because they do not meet the positive and negative selection criteria. Developing T cells are thus susceptible to apoptotic signals. On the other hand, there are mechanisms to prevent developing T cells from premature apoptosis. Maintenance of a fine balance between life and death is thus critical for successful completion of T-cell development. Our recent studies demonstrated an essential role of transcriptional coactivators in maintaining such a balance for developing T cells. Transcriptional coactivators are recruited by transcriptional factors to quantitatively regulate gene expression via modifying chromatin structure. Two transcriptional factors, TCF-1 and RORγt, are required to upregulate the levels of Bcl-xL, a critical survival factor for CD4+CD8+ double-positive thymocytes. However, TCF-1 and RORγt by themselves are not sufficient to stimulate Bcl-xL expression. Transcriptional coactivator β-catenin recruited by TCF-1, and steroid receptor coactivators (SRCs) recruited by RORγt, are also required for optimal stimulation of Bcl-xL expression. Thus, transcriptional coactivators are a substantial component of the transcriptional machinery to regulate thymocye survival, ensuring the completion of T-cell development.


Articles with similar content:

Transcription Factor Network Regulating CD+CD8+ Thymocyte Survival
Critical Reviews™ in Immunology, Vol.31, 2011, issue 6
Yan Ding, Zuoming Sun, Jian Ma, Zhaofeng Huang, Huimin Xie, Xianfeng Fang, Ruiqing Wang
The Role of OX40-Mediated Co-stimulation in T-Cell Activation and Survival
Critical Reviews™ in Immunology, Vol.29, 2009, issue 3
Carl E. Ruby, Andrew D. Weinberg, William L. Redmond
The Contribution of Thymic Stromal Abnormalities to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Melanie N. Hince, Adrienne Calder, Anne L. Fletcher, Ann P. Chidgey, Richard L. Boyd
Regulation of Immune Response by P2X7 Receptor
Critical Reviews™ in Immunology, Vol.26, 2006, issue 6
Celia F. Brosnan, Lanfen Chen
Signaling Pathways Involved in Glucocorticoid-Induced Apoptosis of Thymocytes
Critical Reviews™ in Immunology, Vol.25, 2005, issue 4
Francoise Giraud, Jean-Claude Sulpice, Sandrine Lepine