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Critical Reviews™ in Immunology
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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i4.10
pages 251-262

Mechanisms Regulating Lymphocytic Infiltration of the Thyroid in Murine Models of Thyroiditis

Sergio A. Lira
Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1630, New York, NY 10029-6574
Andrea P. Martin
Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1630, New York, NY 10029-6574
Tatjana Marinkovic
Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1630, New York, NY 10029-6574
Glaucia C. Furtado
Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1630, New York, NY 10029-6574

ABSTRAKT

The autoimmune diseases of the thyroid are the most prevalent autoimmune diseases in man. In these diseases, the thyroid is invariably infiltrated by lymphocytes, which play a major role in pathogenesis. In this review, we discuss the mechanisms associated with lymphocytic infiltration of the thyroid, examining different models of thyroid autoimmune disease in mice.


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