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ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
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Response of γδ T Cells to Plant-Derived Tannins
ABSTRAKT
Many pharmaceutical drugs arc isolated from plants used in traditional medicines, and new plant-derived pharmaceutical drugs continue to be identified. Relevant to this review, different plant-derived agonists for γδ T cells are described that impart effector functions upon distinct subsets of these cells. Recently, plant tannins have been defined as one class of γδ T cell agonist and appear to preferentially activate the mucosal population. Mucosal γδ T cells function to modulate tissue immune responses and induce epithelium repair. Select tannins, isolated from apple peel, rapidly induce immune gene transcription in γδ T cells, leading to cytokinc production and increased responsiveness to secondary signals. Activity of these tannin preparations tracks to the procyanidin fraction, with the procyanidin trimer (C1) having the most robust activity defined to date. The response to the procyanidins is evolutionarily conserved in that responses are seen with human, bovine, and murine γδ T cells, although human cells show less selectivity. Procyanidin-induced responses described in this review likely account for the expansion of mucosal γδ T cells seen in mice and rats fed soluble extracts of tannins. Use of procyanidins to activate γδ T cells may represent a novel approach for the treatment of tissue damage and autoimmune diseases.
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