Abo Bibliothek: Guest
Critical Reviews™ in Immunology

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

IL-2-lnduced Cellular Events

Volumen 18, Ausgabe 3, 1998, pp. 185-220
DOI: 10.1615/CritRevImmunol.v18.i3.20
Get accessGet access

ABSTRAKT

In this review we discuss several molecules that are attractive candidates as transducing molecules involved in signaling processes. IL-2 receptor signaling is a complex process involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and Rho have been defined as dual molecules because Ras- and Rho-initiated signals can either promote or inhibit apoptosis.
Several studies have contributed to the delineation of a signaling pathway structured in three independent channels designated channels 1, 2, and 3. These three channels serve as major landmarks: Lck-c-fos/c-jun (channel 1), Syk-myc (channel 2), and a pathway leading to actin organization/bcl-2 expression (channel 3). The detailed hierarchical organization of these three channels is presented throughout the review and the model is depicted in the figure.

REFERENZIERT VON
  1. Massey H. Davis, McPherson Richard A., Mediators of Inflammation, in Henry's Clinical Diagnosis and Management by Laboratory Methods, 2011. Crossref

  2. Tsitoura Daphne C., Rothman Paul B., Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells, Journal of Clinical Investigation, 113, 4, 2004. Crossref

  3. Wells Andrew D., Cell-cycle regulation of T-cell responses - novel approaches to the control of alloimmunity, Immunological Reviews, 196, 1, 2003. Crossref

  4. Tai Yu-Ting, Cherng Yih-Giun, Chang Chia-Chen, Hwang Yi-Ping, Chen Jui-Tai, Chen Ruei-Ming, Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediatedBcl-2 gene expression and protein translocation, Journal of Orthopaedic Research, 25, 5, 2007. Crossref

  5. Gaffen Sarah L., SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR, Cytokine, 14, 2, 2001. Crossref

  6. Wang Tian, Alam Raeful, Langley Keith E., Klimpel Gary R., Stem Cell Factor and IL-2 Act Synergistically in Inducing Intraepithelial Lymphocyte Proliferation and Cytokine Production: Upregulation of the IL-2 Receptor γ-Chain and Signaling via JAK-3, Cellular Immunology, 205, 1, 2000. Crossref

  7. Olmo Maite del, Alonso-Varona Ana, Castro Begoña, Bilbao Pedro, Palomares Teodoro, Cytomodulation of interleukin-2 effect by l-2-oxothiazolidine-4-carboxylate on human malignant melanoma, Cancer Immunology, Immunotherapy, 55, 8, 2006. Crossref

  8. Yan Mingda, Xu Weijin, Lu Linrong, Sun Lanying, Liu Xinyuan, Zheng Zhongcheng, Induction of Ref-1 Ensures AP-1 Activation in Intracellular Oxidative Environment of IL-2-Stimulated BA/F3β Cells, Biochemical and Biophysical Research Communications, 278, 2, 2000. Crossref

  9. Noe Sasha N, Newton Cathy, Widen Raymond, Friedman Herman, Klein Thomas W, Anti-CD40, anti-CD3, and IL-2 stimulation induce contrasting changes in CB1 mRNA expression in mouse splenocytes, Journal of Neuroimmunology, 110, 1-2, 2000. Crossref

  10. Schaecher Kurt E, Goust Jean-Michael, Banik Naren L, The effects of calpain inhibition upon IL-2 and CD25 expression in human peripheral blood mononuclear cells, Journal of Neuroimmunology, 119, 2, 2001. Crossref

  11. Driesen Julia, Popov Alexey, Schultze Joachim L., CD25 as an immune regulatory molecule expressed on myeloid dendritic cells, Immunobiology, 213, 9-10, 2008. Crossref

  12. Wang Gaofeng, Lu Chunrong, Liu Huiling, Jin Weilin, Jiao Xiying, Wei Gengze, Chen Jiankang, Zhu Yunlong, Immunohistochemical localization of interleukin-2 and its receptor subunits α, β and γ in the main olfactory bulb of the rat, Brain Research, 893, 1-2, 2001. Crossref

  13. Todosenko N.M., Khaziakhmatova O.G., Yurova K.A., Malinina I.P., Litvinova L.S., The influence of methylprednisolone on the ability of CD4+CD95+HLA-DR+ T-cells to produce proinflammatory medators in cultures of TCR-activated CD3+CD45RO+ T-lymphocytes from patients with rheumatoid arthritis, Biomeditsinskaya Khimiya, 63, 3, 2017. Crossref

  14. Kaba Aboubacar, Ilunga Lulla A., Chany Charles, Role of Sarcolectin (SCL) and Interferons in Coordinated T Cell Clonal Expansion, Journal of Interferon & Cytokine Research, 20, 5, 2000. Crossref

  15. Hieronymus T, Blank N, Gruenke M, Winkler S, Haas J-P, Kalden J R, Lorenz H-M, CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes, Cell Death & Differentiation, 7, 6, 2000. Crossref

  16. Bilbao P., del Olmo M., Alonso-Varona A., Castro B., Bilbao J., Palomares T., l-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases, Melanoma Research, 12, 1, 2002. Crossref

  17. Dong Chen, Yang Derek D., Tournier Cathy, Whitmarsh Alan J., Xu Jie, Davis Roger J., Flavell Richard A., JNK is required for effector T-cell function but not for T-cell activation , Nature, 405, 6782, 2000. Crossref

  18. Eckenberg Ralph, Moreau Jean-Louis, Melnyk Oleg, Thèze Jacques, IL-2Rβ Agonist P1–30 Acts in Synergy with IL-2, IL-4, IL-9, and IL-15: Biological and Molecular Effects, The Journal of Immunology, 165, 8, 2000. Crossref

  19. Cruz I, Meijer C J L M, Walboomers J M M, Snijders P J F, Waal I Van der, Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas, British Journal of Cancer, 81, 5, 1999. Crossref

  20. Rustemeyer Thomas, van Hoogstraten Ingrid M. W., von Blomberg B. Mary E., Scheper Rik J., Mechanisms in Allergic Contact Dermatitis, in Textbook of Contact Dermatitis, 2001. Crossref

  21. Hayashida Kenji, Shimaoka Yasunori, Ochi Takahiro, Lipsky Peter E, Rheumatoid Arthritis Synovial Stromal Cells Inhibit Apoptosis and Up-Regulate Bcl-xLExpression by B Cells in a CD49/CD29-CD106-Dependent Mechanism, The Journal of Immunology, 164, 2, 2000. Crossref

  22. Rustemeyer Thomas, van Hoogstraten Ingrid M. W., von Blomberg B. Mary E., Gibbs Sue, Scheper Rik J., Mechanisms of Irritant and Allergic Contact Dermatitis, in Contact Dermatitis, 2011. Crossref

  23. Hess David A., O'Leary Erin F., Lee James T., Almawi Wassim Y., Madrenas Joaquín, Rieder Michael J., Inhibition of cytokine production and interference in IL‐2 receptor‐mediated Jak‐Stat signaling by the hydroxylamine metabolite of sulfamethoxazole, The FASEB Journal, 15, 10, 2001. Crossref

  24. Benbernou Naima, Muegge Kathrin, Durum Scott K., Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Rα, Journal of Biological Chemistry, 275, 10, 2000. Crossref

  25. Jones David R., Pettitt Trevor R., Sanjuán Miguel A., Mérida Isabel, Wakelam Michael J.O., Interleukin-2 Causes an Increase in Saturated/Monounsaturated Phosphatidic Acid Derived from 1,2-Diacylglycerol and 1-O-Alkyl-2-acylglycerol, Journal of Biological Chemistry, 274, 24, 1999. Crossref

  26. Devireddy Laxminarayana R., Green Michael R., Transcriptional Program of Apoptosis Induction following Interleukin 2 Deprivation: Identification of RC3, a Calcium/Calmodulin Binding Protein, as a Novel Proapoptotic Factor, Molecular and Cellular Biology, 23, 13, 2003. Crossref

  27. Zujewski J., Horak I.D., Bol C.J., Woestenborghs R., Bowden C., End D.W., Piotrovsky V.K., Chiao J., Belly R.T., Todd A., Kopp W.C., Kohler D.R., Chow C., Noone M., Hakim F.T., Larkin G., Gress R.E., Nussenblatt R.B., Kremer A.B., Cowan K.H., Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer, Journal of Clinical Oncology, 18, 4, 2000. Crossref

  28. Hehner Steffen P., Hofmann Thomas G., Dienz Oliver, Dröge Wulf, Schmitz M.Lienhard, Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription, Journal of Biological Chemistry, 275, 24, 2000. Crossref

  29. Crul M., de Klerk G. J., Swart M., van’t Veer L. J., de Jong D., Boerrigter L., Palmer P. A., Bol C. J., Tan H., de Gast G. C., Beijnen J. H., Schellens J. H.M., Phase I Clinical and Pharmacologic Study of Chronic Oral Administration of the Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer, Journal of Clinical Oncology, 20, 11, 2002. Crossref

  30. Hofmann Thomas G, Hehner Steffen P, Dröge Wulf, Schmitz M Lienhard, Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription, Oncogene, 19, 9, 2000. Crossref

  31. Moulder Stacy L., Mahany John J., Lush Richard, Rocha-Lima Caio, Langevin Michael, Ferrante Karen J., Bartkowski Lisa Michele, Kajiji Shama M., Noe Dennis A., Paillet Simone, Sullivan Daniel M., A Phase I Open Label Study of the Farnesyltransferase Inhibitor CP-609,754 in Patients with Advanced Malignant Tumors, Clinical Cancer Research, 10, 21, 2004. Crossref

  32. Gadina Massimo, Sudarshan Chitra, O’Shea John J., IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3′-Kinase, and Grb2, The Journal of Immunology, 162, 4, 1999. Crossref

Zukünftige Artikel

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain