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Critical Reviews™ in Immunology

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ISSN Druckformat: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Proteases and Cell-Mediated Cytotoxicity

Volumen 18, Ausgabe 3, 1998, pp. 255-273
DOI: 10.1615/CritRevImmunol.v18.i3.50
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ABSTRAKT

Cytotoxic T lymphocytes and natural killer cells represent the body’s primary defense against viral-infected and tumorigenic cells. The classically described mechanism by which these cells induce target cell death is granule mediated: cytolytic granules within the killer cell are directionally exocytozed toward the target cell, and the granule contents inflict a "lethal hit" on the target cell. A second mechanism of cytotoxicity is now known to exist, and utilizes cell surface receptors on the target cell, for which the ligand is expressed on the killer cell. Receptor oligomerization results in the recruitment of cytoplasmic proteins to the receptors and the transduction of a death signal to the target cell. In both granule- and receptor-mediated cytotoxicity, the target cell dies through a defined series of steps, which together are termed apoptosis. Recent work on apoptosis has defined a family of cysteine proteases, the caspases, which appear to be involved in the initiation of apoptosis in response to a number of stimuli. This review focuses on studies that link these proteases to target cell death induced by cytotoxic cells.

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