Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
Indexed in
Measuring Emigration of Human Thymocytes by T-Cell Receptor Excision Circles
ABSTRAKT
Recent advances in characterizing thymic function confirm the importance of thymus to T-cell diversity in the periphery of both children and adults during both health and disease. Lack of a marker to identify human recent thymic emigrants (RTEs) is the biggest hurdle to accurately characterizing and quantifying thymic output. T-cell receptor excision circles (TRECs) are used as an assay to measure RTE levels. Controversy exists, however, as to whether TREC concentrations reflect the number of RTEs or are mainly altered by peripheral T-cell division and death. In this review, we first summarize recent data on the human thymus and RTEs. On the basis of both experimental and mathematical analyses, we characterize factors that influence TREC dynamics in the periphery and elucidate primary elements that induce a decline in TREC concentrations during normal aging and HIV-1 infection. Our findings suggest that T-cell dynamics are key to the accuracy of TREC concentrations as a useful measurement of human RTEs.
-
Lev Atar, Simon Amos J., Amariglio Ninette, Rechavi Gideon, Somech Raz, Thymic functions and gene expression profile distinct double-negative cells from single positive cells in the autoimmune lymphoproliferative syndrome, Autoimmunity Reviews, 11, 10, 2012. Crossref
-
Cox Amanda L., Thompson Sara A. J., Jones Joanne L., Robertson Vicki H., Hale Geoff, Waldmann Herman, Compston D. Alastair S., Coles Alasdair J., Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis, European Journal of Immunology, 35, 11, 2005. Crossref
-
Albers Ruud, Antoine Jean-Michel, Bourdet-Sicard Raphaëlle, Calder Philip C., Gleeson Michael, Lesourd Bruno, Samartín Sonia, Sanderson Ian R., Van Loo Jan, Vas Dias F. Willem, Watzl Bernhard, Markers to measure immunomodulation in human nutrition intervention studies, British Journal of Nutrition, 94, 3, 2005. Crossref
-
Lev Atar, Amariglio Ninette, Levy Yael, Spirer Zvi, Anikster Yair, Rechavi Gideon, Dekel Benjamin, Somech Raz, Molecular assessment of thymic capacities in patients with Schimke immuno-osseous dysplasia, Clinical Immunology, 133, 3, 2009. Crossref
-
Abedin Sameem, Michel Joshua J., Lemster Bonnie, Vallejo Abbe N., Diversity of NKR expression in aging T cells and in T cells of the aged: The new frontier into the exploration of protective immunity in the elderly, Experimental Gerontology, 40, 7, 2005. Crossref
-
Bona Roberta, Macchia Iole, Baroncelli Silvia, Negri Donatella R.M., Leone Pasqualina, Pavone-Cossut Maria Rosaria, Catone Stefania, Buffa Viviana, Ciccozzi Massimo, Heeney Jonathan, Fagrouch Zahra, Titti Fausto, Cara Andrea, T cell receptor excision circles (TRECs) analysis during acute intrarectal infection of cynomolgus monkeys with pathogenic chimeric simian human immunodeficiency virus, Virus Research, 126, 1-2, 2007. Crossref
-
Johnson Victor J, He Quanren, Osuchowski Marcin F, Sharma Raghubir P, Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations, Toxicology, 201, 1-3, 2004. Crossref
-
Collier Fiona M, Tang Mimi L K, Martino David, Saffery Richard, Carlin John, Jachno Kim, Ranganathan Sarath, Burgner David, Allen Katrina J, Vuillermin Peter, Ponsonby Anne-Louise, The ontogeny of naïve and regulatory CD4+ T-cell subsets during the first postnatal year: a cohort study, Clinical & Translational Immunology, 4, 3, 2015. Crossref
-
Sugita Junichi, Iwao Noriaki, Tanaka Junji, Kato Naoko, Shiratori Souichi, Wakasa Kentarou, Shigematsu Akio, Toubai Tomomi, Takahata Mutsumi, Kondo Takeshi, Asaka Masahiro, Imamura Masahiro, T cell receptor excision circle levels in CD94-expressing CD8 T Cells during graft-versus-host disease, Leukemia & Lymphoma, 49, 7, 2008. Crossref
-
Castro Mario, Lythe Grant, Molina-París Carmen, Ribeiro Ruy M., Mathematics in modern immunology, Interface Focus, 6, 2, 2016. Crossref
-
Alizadeh Zahra, Mazinani Marzieh, Houshmand Masoud, Shakerian Leila, Nourizadeh Maryam, Pourpak Zahra, Fazlollahi Mohammad Reza, Genetic Analysis of Patients with Two Different Types of Hyper IgM Syndrome, Immunological Investigations, 47, 7, 2018. Crossref
-
Nourizadeh Maryam, Shakerian Leila, Borte Stephan, Fazlollahi Mohammadreza, Badalzadeh Mohsen, Houshmand Massoud, Alizadeh Zahra, Dalili Hossein, Rashidi-Nezhad Ali, Kazemnejad Anoshirvan, Moin Mostafa, Hammarström Lennart, Pourpak Zahra, Newborn screening using TREC/KREC assay for severe T and B cell lymphopenia in Iran, Scandinavian Journal of Immunology, 88, 2, 2018. Crossref
-
Uhlin Michael, Sairafi Darius, Berglund Sofia, Thunberg Sarah, Gertow Jens, Ringden Olle, Uzunel Mehmet, Remberger Mats, Mattsson Jonas, Mesenchymal Stem Cells Inhibit Thymic Reconstitution After Allogeneic Cord Blood Transplantation, Stem Cells and Development, 21, 9, 2012. Crossref
-
Jaspan Heather B, Lawn Stephen D, Safrit Jeffrey T, Bekker Linda-Gail, The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents, AIDS, 20, 4, 2006. Crossref
-
Huang Shuaibo, Ding Ru, Lin Yi, He Zhiqing, Wu Feng, Dai Xianliang, Chen Yihong, Gui Yanping, Huang Zhigang, Wu Zonggui, Liang Chun, Reduced T-Cell Thymic Export Reflected by sj-TREC in Patients with Coronary Artery Disease, Journal of Atherosclerosis and Thrombosis, 23, 5, 2016. Crossref
-
van den Broek Theo, Borghans José A. M., van Wijk Femke, The full spectrum of human naive T cells, Nature Reviews Immunology, 18, 6, 2018. Crossref
-
Baev Denis V., Peng Xiao-hui, Song Liping, Barnhart Jerry R., Crooks Gay M., Weinberg Kenneth I., Metelitsa Leonid S., Distinct homeostatic requirements of CD4+ and CD4- subsets of Vα24-invariant natural killer T cells in humans, Blood, 104, 13, 2004. Crossref
-
Kohler Siegfried, Keil Thomas, Alexander Tobias, Thiel Andreas, Swierzy Marc, Ismail Mahmoud, Rückert Jens Carsten, Meisel Andreas, Altered naive CD4+ T cell homeostasis in myasthenia gravis and thymoma patients, Journal of Neuroimmunology, 327, 2019. Crossref
-
Popova N. N., Savchenko V. G., Reconstitution of T-cell-mediated immunity in patients after allogeneic stem cell transplantation, Russian journal of hematology and transfusiology, 65, 1, 2020. Crossref
-
Kwok Janette S. Y., Cheung Stephen K. F., Ho Jenny C. Y., Tang Ivan W. H., Chu Patrick W. K., Leung Eric Y. S., Lee Pamela P. W., Cheuk Daniel K. L., Lee Vincent, Ip Patrick, Lau Y. L., Establishing Simultaneous T Cell Receptor Excision Circles (TREC) and K-Deleting Recombination Excision Circles (KREC) Quantification Assays and Laboratory Reference Intervals in Healthy Individuals of Different Age Groups in Hong Kong, Frontiers in Immunology, 11, 2020. Crossref
-
Hudson Lori L., Louise Markert M., Devlin Blythe H., Haynes Barton F., Sempowski Gregory D., Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection, Seminars in Immunology, 19, 5, 2007. Crossref
-
Tolstykh E. I., Vozilova A. V., Degteva M. O., Akleyev A. V., Concept of T-Cell Genus as a Basis for Analysis of the Results of Cytogenetic Studies after Local Bone Marrow Exposure, Biology Bulletin, 47, 11, 2020. Crossref
-
Lev A, Amariglio N, Spirer Z, Katz U, Bielorai B, Rechavi G, Somech R, Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation, Bone Marrow Transplantation, 45, 6, 2010. Crossref
-
Cheremokhin Dmitrii A., Shinwari Khyber, Deryabina Svetlana S., Bolkov Michail A., Tuzankina Irina A., Kudlay Dmitrii A., Analysis of the TREC and KREC Levels in the Dried Blood Spots of Healthy Newborns with Different Gestational Ages and Weights, Acta Naturae, 14, 1, 2022. Crossref
-
Deya-Martinez Angela, Flinn Aisling M., Gennery Andrew R., Neonatal thymectomy in children—accelerating the immunologic clock?, Journal of Allergy and Clinical Immunology, 146, 2, 2020. Crossref