Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Critical Reviews™ in Immunology
Impact-faktor: 1.404 5-jähriger Impact-Faktor: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volumen 40, 2020 Volumen 39, 2019 Volumen 38, 2018 Volumen 37, 2017 Volumen 36, 2016 Volumen 35, 2015 Volumen 34, 2014 Volumen 33, 2013 Volumen 32, 2012 Volumen 31, 2011 Volumen 30, 2010 Volumen 29, 2009 Volumen 28, 2008 Volumen 27, 2007 Volumen 26, 2006 Volumen 25, 2005 Volumen 24, 2004 Volumen 23, 2003 Volumen 22, 2002 Volumen 21, 2001 Volumen 20, 2000 Volumen 19, 1999 Volumen 18, 1998 Volumen 17, 1997 Volumen 16, 1996 Volumen 15, 1995 Volumen 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i5.20
pages 391-406

Structure and Function of Cas-L and Integrin-Mediated Signaling

Sachiko Seo
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Motoshi Ichikawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Mineo Kurokawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

ABSTRAKT

Cas-L (Crk-associated substrate lymphocyte type), also known as HEF1 (human enhancer of filamentation 1) or NEDD9 (neural precursor cell-expressed, developmentally downregulated gene 9), is an adapter protein at focal adhesions and transmits various signals, mainly induced by integrins. Cas-L is a member of the Cas family proteins and is expressed preferentially in lymphocytes and epithelial cells. A number of previous studies have suggested that Cas-L plays an important role in lymphocyte movement and cell cycle. Recently, we reported a novel function of Cas-L in the immune system using gene-targeted mice. The Cas-L-deficient lymphocytes showed insufficient chemotactic response and perturbed сеll adhesion. Moreover, a deficit of marginal zone (MZ) B cells was detected in the mutant mice. Here, we review the structure of Cas-L and several signaling pathways in which Cas-L is involved, based on the previous in vitro studies. Subsequently, biological functions of Cas-L and the relevance of Cas-L to human diseases are discussed.


Articles with similar content:

Structure and Function of the Immune Semaphorin CD100/SEMA4D
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Abdellah Elhabazi, Armand Bensussan, Laurence Boumsell, Isabelle Chabbert-de Ponnat, Anne Marie-Cardine
Genes for Control of Spread of the Tumor and Mycobacterium tuberculosis Infection in the Mouse
Critical Reviews™ in Immunology, Vol.14, 1994, issue 3-4
Igor K. Egorov, Boris V. Nickonenko
Latent Membrane Protein 1 and the B Lymphocyte−A Complex Relationship
Critical Reviews™ in Immunology, Vol.34, 2014, issue 3
Gail A. Bishop, Laura L. Stunz
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Taro Kawai, Noor Hasima Nagoor, Sophia P. M. Sok, Daisuke Ori
The Adhesion- and Degranulation-Promoting Adaptor Protein and Its Role in the Modulation of Experimental Autoimmune Encephalomyelitis
Critical Reviews™ in Immunology, Vol.35, 2015, issue 1
Annegret Reinhold, Stefanie Kliche, Dirk Reinhold, Mauro Togni, Swen Engelmann, Burkhart Schraven