Abo Bibliothek: Guest
Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen
Journal of Long-Term Effects of Medical Implants
SJR: 0.145 SNIP: 0.491 CiteScore™: 0.89

ISSN Druckformat: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v21.i2.60
pages 159-167

Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study

Jun Sik Son
Research Center for Oral Disease Regulation of the Aged, Chosun University, Korea
Jong Min Kim
College of Veterinary Medicine, Chungbuk National University, Korea
Myungho Han
Department Display & Chemical Engineering, Kyungil University, Gyeongbuk, Korea
Seok Hwa Choi
College of Veterinary Medicine, Chungbuk National University, Korea
Francis Y. Lee
Department of Orthopaedic Surgery, Center for Orthopaedic Research, Columbia University, NY
Daniel Oh
Columbia University Medical Center


Bone defects resulting from trauma or pathology represent a common and significant clinical problem. In this study, hydroxyapatite (HAp)-alumina bi-layered scaffolds, which have the benefits of both HAp (i.e., osteointegration, osteoconduction) and alumina (i.e., hardness) were used as a bone substitute for the repair of large segmental defects (20 mm) created in a beagle tibia model. Highly porous bi-layered scaffolds with isotropic-pore structures were fabricated using a polymer-template coating technique. The pore sizes obtained using this approach ranged between 230 μm and 470 μm, and porosity was 91.61±1.28%. Using scanning electron microscopy and energy dispersive spectroscopy, it was confirmed that the frame of each bi-layered scaffold consisted of an alumina inner layer and HAp outer layer. The evaluation of bone regeneration within each scaffold after implantation in the beagle tibia was performed using CT, micro-CT, scintigraphy. New bone formation was evident in the large segmental defects treated with HAp/alumina scaffolds. It was concluded from this study that the HAp/alumina bi-layered scaffold is instrumental in inducing host-scaffold engraftment at the distal and proximal ends of the defect as well as distributing the newly formed bone throughout each scaffold 8 weeks post-implantation.

Articles with similar content:

Long-Term Follow-Up Study of Bioactive Bone Cement for Repairing a Segmental Defect in a Canine Femur

Journal of Long-Term Effects of Medical Implants, Vol.11, 2001, issue 1&2
Jiro Tamura, Takashi Nakamura, Shunsuke Fujibayashi, Satoshi Yoshihara, Yoshinaga Senaha
Catastrophic Stem Taper Wear in Ceramic on Polyethylene Bearing Couple: A Case Report
Journal of Long-Term Effects of Medical Implants, Vol.24, 2014, issue 2-3
Mariko Katsui, Masashi Tsuchida, Atsushi Kusaba, Saiji Kondo, Akihiko Maeda, Naoyuki Hakuta
Characterization of an Endovascular Prosthesis Using the 3Bs Rule (Biocompatibility, Biofunctionality and Biodurability): A Recommended Protocol to Investigate a Device Harvested at Necropsy
Journal of Long-Term Effects of Medical Implants, Vol.17, 2007, issue 3
Robert Guidoin, Xiaoyan Deng, Randolph Guzman, Tieying Yin, Robert McGregor, Yvan Douville, Martin King, Jean-Pierre Renou, Georgi R. Marinov, Hongbo Zhang, Yubo Fan, Robert M. Geelkerken, Mark Nutley, Ze Zhang, Zaipin Xu, Andre-Pierre Legrand, Guy Dionne, Stephane Turgeon, Nilesh Ingle, Amidou Traore
A Biomechanical Study of Unilateral Posterior Atlantoaxial Transarticular Screw Fixation
Journal of Long-Term Effects of Medical Implants, Vol.15, 2005, issue 1
Alan L. Ogden, Lois Ann Nichols, Debi P. Mukherjee, Kalia K. Sadasivan, James A. Albright
Failure of a Medial Unicompartmental Knee Replacement due to Metal Allergy
Journal of Long-Term Effects of Medical Implants, Vol.28, 2018, issue 4
Shamsul Khan, Theodore Balfousias, George Tselentakis, Bala Srikanth, Alexandros P. Apostolopoulos