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ISSN Druckformat: 1050-6934
ISSN Online: 1940-4379
Indexed in
Collective Review: Bioactive Implants Coated with Poly(D,L-lactide) and Growth Factors IGF-I, TGF-β1, or BMP-2 for Stimulation of Fracture Healing
ABSTRAKT
Demographic data reveal that due to the increasing aging of the population, complications with the musculoskeletal system will increase in the next years. One major problem in orthopedic and trauma surgery are the delayed healing or non-unions of long bone fractures. The exogenous application of growth factors can stimulate the bone healing to reduce these complications. Beside the choice of the optimal growth factor the application system is important. Therefore, we developed a new bioactive coating method for implants, which is based on a biodegradable poly(D,L-lactide) (coating thickness: 10 μm).This coating allows the incorporation of growth factors and the controlled release of these factors during the healing process without the need for further devices. The effect of different growth factors (IGF-I, TGF-β1, and BMP-2) locally released from coated intramedullary implants on fracture healing was investigated with biomechanical and histological analysis in rats.
All investigated growth factors stimulated the fracture healing as assessed with biomechanical tests and histological analysis. The local application of combined IGF-I and TGF-β1 had the most stimulating effect on fracture healing, followed by the effect of BMP-2, IGF-I, and TGF-β1 alone. Bioactive coating of biomechanical well-established implants can on the one hand stabilize the fracture and on the other hand stimulate healing processes to increase healing and to reduce the rate of complications.
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Nandi Samit K., Kundu Biswanath, Basu Debabrata, Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties, Materials Science and Engineering: C, 33, 3, 2013. Crossref
-
Bauer Sebastian, Schmuki Patrik, von der Mark Klaus, Park Jung, Engineering biocompatible implant surfaces, Progress in Materials Science, 58, 3, 2013. Crossref
-
Jakobsen Stig S., Larsen Agnete, Stoltenberg Meredin, Bruun Jens M., Soballe Kjeld, Hydroxyapatite Coatings Did not Increase TGF-β and BMP-2 Secretion in Murine J774A.1 Macrophages, but Induced a Pro-inflammatory Cytokine Response, Journal of Biomaterials Science, Polymer Edition, 20, 4, 2009. Crossref
-
de Jonge Lise T., Leeuwenburgh Sander C. G., Wolke Joop G. C., Jansen John A., Organic–Inorganic Surface Modifications for Titanium Implant Surfaces, Pharmaceutical Research, 25, 10, 2008. Crossref
-
BALDINI N., CENNI E., CIAPETTI G., GRANCHI D., SAVARINO L., Bone repair and regeneration, in Bone Repair Biomaterials, 2009. Crossref
-
Schnettler Reinhard, Knöß Peter D., Heiss Christian, Stahl Jens-Peter, Meyer Christof, Kilian Olaf, Wenisch Sabine, Alt Volker, Enhancement of bone formation in hydroxyapatite implants by rhBMP-2 coating, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 90B, 1, 2008. Crossref
-
Levy Yair, Paz Adrian, Yosef Rami Ben, Corn Benjamin W., Vaisman Boris, Shuhat Shaul, Domb Abraham J., Biodegradable inflatable balloon for reducing radiation adverse effects in prostate cancer, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 91B, 2, 2009. Crossref
-
Porter Joshua R., Ruckh Timothy T., Popat Ketul C., Bone tissue engineering: A review in bone biomimetics and drug delivery strategies, Biotechnology Progress, 2009. Crossref
-
Heidenhain Christoph, Veeravoorn Ariyakhagorn, Vachkov Blagovest, Weichert Wilko, Schmidmaier Gerhard, Wildemann Britt, Neuhaus Peter, Heise Michael, Fibroblast and Vascular Endothelial Growth Factor Coating of Decellularized Vascular Grafts Stimulates Undesired Giant Cells and Graft Encapsulation in a Rat Model, Artificial Organs, 35, 1, 2011. Crossref
-
McGuigan Fiona E., Larzenius Emma, Callreus Mattias, Gerdhem Paul, Luthman Holger, Åkesson Kristina, Variation in the BMP2 Gene: Bone Mineral Density and Ultrasound in Young Adult and Elderly Women, Calcified Tissue International, 81, 4, 2007. Crossref
-
Heidenhain Christoph, Weichert Wilko, Schmidmaier Gerhard, Wildemann Britt, Hein Moritz, Neuhaus Peter, Heise Michael, Polymer coating of porcine decellularized and cross-linked aortic grafts, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2010. Crossref
-
Swami Nathan, Cui Zhanwu, Nair Lakshmi S., Titania Nanotubes: Novel Nanostructures for Improved Osseointegration, Journal of Heat Transfer, 133, 3, 2011. Crossref
-
Baroli Biancamaria, From natural bone grafts to tissue engineering therapeutics: Brainstorming on pharmaceutical formulative requirements and challenges, Journal of Pharmaceutical Sciences, 98, 4, 2009. Crossref
-
Chen Hua, Cui Xu, Yu Xuezhong, Tian XueZhong, Zhang BoXun, Tang Peifu, Wang Yan, Effects of Chitosan-Coated Pressed Calcium Sulfate Pellets Combined With Recombinant Human Bone Morphogenetic Protein 2 on Bone Formation in Femoral Condyle-Contained Bone Defects, Journal of Craniofacial Surgery, 21, 1, 2010. Crossref
-
Szczęsny Grzegorz, Olszewski Waldemar L., Zagozda Małgorzata, Rutkowska Joanna, Czapnik Żanetta, Swoboda-Kopeć Ewa, Górecki Andrzej, Genetic factors responsible for long bone fractures non-union, Archives of Orthopaedic and Trauma Surgery, 131, 2, 2011. Crossref
-
Devescovi Valentina, Leonardi Elisa, Ciapetti Gabriela, Cenni Elisabetta, Growth factors in bone repair, La Chirurgia degli Organi di Movimento, 92, 3, 2008. Crossref
-
Giannoudis Peter V., Psarakis Spyridon, Kanakaris Nikolaos K., Pape Hans-Christoph, Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions, Injury, 38, 2007. Crossref
-
Franz Sandra, Rammelt Stefan, Scharnweber Dieter, Simon Jan C., Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials, Biomaterials, 32, 28, 2011. Crossref
-
Waknis Vrushali, Jonnalagadda Sriramakamal, Novel poly-DL-lactide-polycaprolactone copolymer based flexible drug delivery system for sustained release of ciprofloxacin, Drug Delivery, 18, 4, 2011. Crossref
-
Calori G.M., Donati D., Di Bella C., Tagliabue L., Bone morphogenetic proteins and tissue engineering: future directions, Injury, 40, 2009. Crossref
-
Brandi Maria Luisa, Drugs for bone healing, Expert Opinion on Investigational Drugs, 21, 8, 2012. Crossref
-
Lee Soo-Hong, Shin Heungsoo, Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering, Advanced Drug Delivery Reviews, 59, 4-5, 2007. Crossref
-
Poniatowski Łukasz A., Wojdasiewicz Piotr, Gasik Robert, Szukiewicz Dariusz, Transforming Growth Factor Beta Family: Insight into the Role of Growth Factors in Regulation of Fracture Healing Biology and Potential Clinical Applications, Mediators of Inflammation, 2015, 2015. Crossref
-
Helbig Lars, Guehring Thorsten, Rosenberger Svenja, Ivanova Adriana, Kaeppler Kathrin, Fischer Christian Alexander, Moghaddam Arash, Schmidmaier Gerhard, A new animal model for delayed osseous union secondary to osteitis, BMC Musculoskeletal Disorders, 16, 1, 2015. Crossref
-
Shynlova Oksana, Tsui Prudence, Jaffer Shabana, Lye Stephen J., Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour, European Journal of Obstetrics & Gynecology and Reproductive Biology, 144, 2009. Crossref
-
Payne Anthony M., Messi María Laura, Zheng Zhenlin, Delbono Osvaldo, Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice, Experimental Gerontology, 42, 4, 2007. Crossref
-
Nikolidakis Dimitris, Meijer Gert J., Oortgiesen Daniel A.W., Walboomers X. Frank, Jansen John A., The effect of a low dose of transforming growth factor β1 (TGF-β1) on the early bone-healing around oral implants inserted in trabecular bone, Biomaterials, 30, 1, 2009. Crossref
-
Liu Huibing, Huang Xiaobo, Yu Hanwu, Yang Xiaoning, Zhang Xiangyu, Hang Ruiqiang, Tang Bin, A cytocompatible micro/nano-textured surface with Si-doped titania mesoporous arrays fabricated by a one-step anodization, Materials Science and Engineering: C, 73, 2017. Crossref
-
Veronesi Francesca, Giavaresi Gianluca, Fini Milena, Longo Giovanni, Ioannidu Caterina Alexandra, Scotto d'Abusco Anna, Superti Fabiana, Panzini Gianluca, Misiano Carlo, Palattella Alberto, Selleri Paolo, Di Girolamo Nicola, Garbarino Viola, Politi Laura, Scandurra Roberto, Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon, Materials Science and Engineering: C, 70, 2017. Crossref
-
Vordemvenne Thomas, Paletta Jürgen RJ, Hartensuer Rene, Pap Thomas, Raschke Michael J, Ochman Sabine, Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts, BMC Musculoskeletal Disorders, 12, 1, 2011. Crossref
-
Goldhahn Jörg, Mitlak Bruce, Aspenberg Per, Kanis John A., Rizzoli René, Reginster Jean-Yves, Critical Issues in Translational and Clinical Research for the Study of New Technologies to Enhance Bone Repair, Journal of Bone and Joint Surgery, 90, Supplement_1, 2008. Crossref
-
Shynlova Oksana, Tsui Prudence, Dorogin Anna, Langille B. Lowell, Lye Stephen J., Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat1, Biology of Reproduction, 76, 4, 2007. Crossref
-
Zhang Lili, Ke Jin, Wang Yulan, Yang Shuang, Miron Richard J., Zhang Yufeng, An in vitro investigation of the marked impact of dendritic cell interactions with bone grafts, Journal of Biomedical Materials Research Part A, 105, 6, 2017. Crossref
-
Rahmani Del Bakhshayesh Azizeh, Annabi Nasim, Khalilov Rovshan, Akbarzadeh Abolfazl, Samiei Mohammad, Alizadeh Effat, Alizadeh-Ghodsi Mohammadreza, Davaran Soodabeh, Montaseri Azadeh, Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering, Artificial Cells, Nanomedicine, and Biotechnology, 46, 4, 2018. Crossref
-
SERVIN-TRUJILLO Miguel Angel, REYES-ESPARZA Jorge Alberto, GARRIDO-FARIÑA German, FLORES-GAZCA Enrique, OSUNA-MARTINEZ Ulises, RODRIGUEZ-FRAGOSO Lourdes, Use of a Graft of Demineralized Bone Matrix Along with TGF-β1 Leads to an Early Bone Repair in Dogs, Journal of Veterinary Medical Science, 73, 9, 2011. Crossref
-
Smart Biomaterials in Biomedical Applications, in Smart Biomaterial Devices, 2016. Crossref
-
Um S, Kim HY, Seo B-M, Effects of BMP-2 on the osteogenic differentiation of bone marrow stem cells in fibrous dysplasia, Oral Diseases, 24, 6, 2018. Crossref
-
Reible Bruno, Schmidmaier Gerhard, Moghaddam Arash, Westhauser Fabian, Insulin-Like Growth Factor-1 as a Possible Alternative to Bone Morphogenetic Protein-7 to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells in Vitro, International Journal of Molecular Sciences, 19, 6, 2018. Crossref
-
Sevilla Pablo, Cirera Andrea, Dotor Javier, Gil Francisco Javier, Galindo-Moreno Pablo, Aparicio Conrado, In vitro cell response on CP-Ti surfaces functionalized with TGF-β1 inhibitory peptides, Journal of Materials Science: Materials in Medicine, 29, 6, 2018. Crossref
-
Qiao Haixia, Xiao Hongyuan, Huang Yong, Yuan Cuifang, Zhang Xuejiao, Bu Xiaopei, Wang Zhenhui, Han Shuguang, Zhang Lijuan, Su Zhuobin, Zhang Xiaojun, SiO2 loading into polydopamine-functionalized TiO2 nanotubes for biomedical applications, Surface and Coatings Technology, 364, 2019. Crossref
-
Park J., Yan G., Kwon K.-C., Liu M., Gonnella P.A., Yang S., Daniell H., Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing, Biomaterials, 233, 2020. Crossref
-
Brion Alice, Rammal Hassan, Cell–biomaterials interactions: the role of growth factors, in Handbook of Biomaterials Biocompatibility, 2020. Crossref
-
Javed Fawad, Akram Zohaib, Khan Junad, Zafar Muhammad Sohail, Growth factors and guided bone regeneration, in Dental Implants, 2020. Crossref
-
Qi Jingqi, Yu Tianqi, Hu Bangyan, Wu Hongwei, Ouyang Hongwei, Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine, International Journal of Molecular Sciences, 22, 19, 2021. Crossref
-
Bjelić Dragana, Finšgar Matjaž, The Role of Growth Factors in Bioactive Coatings, Pharmaceutics, 13, 7, 2021. Crossref