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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Alterations in Bronchoalveolar Lavage Constituents, Oxidant/Antioxidant Status, and Lung Histology Following Intratracheal Instillation of Respirable Suspended Particulate Matter

Volumen 24, Ausgabe 1, 2005, pp. 19-32
DOI: 10.1615/JEnvPathToxOncol.v24.i1.30
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ABSTRAKT

Urban suspended particulate pollutants differ with place of occurrence, meteorological conditions, physicochemical compositions, and the response of the bronchopulmonary apparatus. Lung injury following intratracheal instillation of respirable suspended particulate matter (RSPM) collected in an urban setting in India was investigated in rats. The animals were killed 15 days after exposure to 2.5, 5.0, and 10.0 mg of RSPM. We examined the changes in lung histology, enzymatic activity in the bronchoalveolar lavage (BAL), and the oxidant/ antioxidant status in lung homogenates.The alterations in these parameters were compared with those in rats instilled with quartz particulates, which were used as positive controls. Exposure to RSPM resulted in an increase in the relative weight of lungs and inflammatory changes evidenced by an increase in the total cellularity of the lungs, predominantly polymorphonuclear cells, demonstrable both in the lungs sections and in the bronchoalveolar lavage of the exposed animals. An increase in the protein content and in the lactate dehydrogenase activity in the BAL was found in the RSPM-exposed rats. A marked increase in the output of lipid peroxides and a dose-dependent increase in the formation of reactive nitrogen species (NO) in lung homogenates and BAL, respectively, was found in the RSPM-exposed rats. A significant decrease in the enzymatic lung antioxidants, superoxide dismutase, and catalase was observed. However, the alterations in the levels of glutathione in the lungs of the RSPM-exposed animals were not significant. The inflammatory reaction, oxidative changes, and enzyme release, were more marked in quartz-exposed animals in comparison to the RSPM-exposed rats.

REFERENZIERT VON
  1. Cozzi Emily, Hazarika Surovi, Stallings Howard W., Cascio Wayne E., Devlin Robert B., Lust Robert M., Wingard Christopher J., Van Scott Michael R., Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice, American Journal of Physiology-Heart and Circulatory Physiology, 291, 2, 2006. Crossref

  2. Haberzettl Petra, Bhatnagar Aruni, Conklin Daniel J., Particulate Matter and Oxidative Stress – Pulmonary and Cardiovascular Targets and Consequences, in Systems Biology of Free Radicals and Antioxidants, 2014. Crossref

  3. Hatzis Christos, Godleski John J., González-Flecha Beatriz, Wolfson Jack M., Koutrakis Petros, Ambient Particulate Matter Exhibits Direct Inhibitory Effects on Oxidative Stress Enzymes, Environmental Science & Technology, 40, 8, 2006. Crossref

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