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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
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Endotoxin Contamination of Agaricus blazei Murrill Extract Enhances Murine Immunologic Responses and Inhibits the Growth of Sarcoma 180 Implants In Vivo
ABSTRAKT
Agaricus blazei Murrill, a native mushroom of Brazil, has been reported to be an immunoreactant with anti-tumor effect. There are many reports on the anti-tumor effect of Agaricus blazei Murrill; however, the precise mechanism of its effect is not fully understood. In this study, we tried to confirm the anti-tumor effect of Agaricus blazei Murrill against Sarcoma 180 cells in a mouse model and found that an inhibitory effect on tumor growth was induced by peritoneal injection of a freeze-dried, hot water extract of Agaricus blazei Murrill (FAG). We noted that there were differences among each sample in terms of anti-tumor activity. We hypothesized that this was because some contaminants of FAG were affecting the anti-tumor activity. We evaluated cytokine secretion from mouse peritoneal cells incubated with FAG. While high interleukin-6 and tumor necrosis factor-α secretions were observed in response to crude FAG, they were dramatically decreased by the removal of endotoxin from the FAG using an endotoxin-specific polymyxin B-conjugated affinity column. The reductions were synergistically recovered by adding an amount of lipopolysaccharide equivalent to the amount of contaminated endotoxin. Thus, these data suggest that the contaminated endotoxin of Agaricus blazei Murrill may act as an immunomodulator of anti-tumor activity.
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Liu Cui-Cui, Yang Hao, Zhang Ling-Ling, Zhang Qian, Chen Bo, Wang Yi, Biotoxins for Cancer Therapy, Asian Pacific Journal of Cancer Prevention, 15, 12, 2014. Crossref
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Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref
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Dong Sijun, Furutani Yoshiyuki, Suto Yumiko, Furutani Michiko, Zhu Yun, Yoneyama Makoto, Kato Taichi, Itabe Hiroyuki, Nishikawa Toshio, Tomimatsu Hirofumi, Tanaka Takeshi, Kasanuki Hiroshi, Masaki Tomoh, Kiyama Ryoiti, Matsuoka Rumiko, Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract, Microbiological Research, 167, 4, 2012. Crossref