Abo Bibliothek: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Induction of miR-21-PDCD4 Signaling by Tungsten Carbide-Cobalt Nanoparticles in JB6 Cells Involves ROS-Mediated MAPK Pathways

Volumen 32, Ausgabe 1, 2013, pp. 41-51
DOI: 10.1615/JEnvironPatholToxicolOncol.2013007097
Get accessGet access

ABSTRAKT

Tungsten carbide−cobalt (WC-Co) nanoparticle composites have wide applications because of their hardness and toughness. WC-Co was classified as "probably carcinogenic" to humans by the International Agency for Research on Cancer (IARC) in 2003. It is believed that the toxicity and carcinogenesis of WC-Co is associated with particle size. Recent studies demonstrated that the tumor suppressor gene programmed cell death 4 (PDCD4) and its upstream regulator miR-21 have been considered as oncogenes for novel cancer prevention or anticancer therapies. The present study examined the effects of WC-Co nanoparticles on miR-21-PDCD4 signaling in a mouse epidermal cell line (JB6 P+). The results showed that (i) exposure of JB6 cells to WC-Co stimulated a increase of miR-21 generation; (ii) WC-Co also caused inhibition of PDCD4, a tumor suppressor protein and downstream target of miR-21, expression in JB6 cells; (iii) inhibition of ERKs with ERK inhibitor U0126 significantly reversed WC-Cominus;induced PDCD4 inhibition, but inhibition of p38 with p38 inhibitor SB203580 did not; and (iv) ROS scavengers, N-acetyl-L-cysteine and catalase, blocked the inhibitory effect of WC-Co on PDCD4 expression, while superoxide dismutase promoted the inhibitory effect. These findings demonstrate that WC-Co nanoparticles induce miR-21 generation, but inhibit PDCD4 production, which may be mediated through ROS, especially endogenous H2O2, and ERK pathways. Unraveling the complex mechanisms associated with these events may provide insights into the initiation and progression of WC-Co−induced carcinogenesis.

REFERENZIERT VON
  1. Nogueira Daniele Rubert, Rolim Clarice M. Bueno, Farooqi Ammad Ahmad, Nanoparticle Induced Oxidative Stress in Cancer Cells: Adding New Pieces to an Incomplete Jigsaw Puzzle, Asian Pacific Journal of Cancer Prevention, 15, 12, 2014. Crossref

  2. Antognelli Cinzia, Gambelunghe Angela, Muzi Giacomo, Talesa Vincenzo Nicola, Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB, Free Radical Biology and Medicine, 84, 2015. Crossref

  3. Langie Sabine A.S., Koppen Gudrun, Desaulniers Daniel, Al-Mulla Fahd, Al-Temaimi Rabeah, Amedei Amedeo, Azqueta Amaya, Bisson William H., Brown Dustin, Brunborg Gunnar, Charles Amelia K., Chen Tao, Colacci Annamaria, Darroudi Firouz, Forte Stefano, Gonzalez Laetitia, Hamid Roslida A., Knudsen Lisbeth E., Leyns Luc, Lopez de Cerain Salsamendi Adela, Memeo Lorenzo, Mondello Chiara, Mothersill Carmel, Olsen Ann-Karin, Pavanello Sofia, Raju Jayadev, Rojas Emilio, Roy Rabindra, Ryan Elizabeth, Ostrosky-Wegman Patricia, Salem Hosni K., Scovassi A.Ivana, Singh Neetu, Vaccari Monica, Van Schooten Frederik J., Valverde Mahara, Woodrick Jordan, Zhang Luoping, van Larebeke Nik, Kirsch-Volders Micheline, Collins Andrew R., Causes of genome instability: the effect of low dose chemical exposures in modern society, Carcinogenesis, 36, Suppl 1, 2015. Crossref

  4. Bhang Suk Ho, Han Jin, Jang Hyeon-Ki, Noh Myung-Kyung, La Wan-Geun, Yi Minyoung, Kim Woo-Sik, Kim Kwon Yunhee, Yu Taekyung, Kim Byung-Soo, pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity, Biomaterials, 55, 2015. Crossref

  5. Traboulsi Hussein, Guerrina Necola, Iu Matthew, Maysinger Dusica, Ariya Parisa, Baglole Carolyn, Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter, International Journal of Molecular Sciences, 18, 2, 2017. Crossref

  6. Hussain Salik, Garantziotis Stavros, Rodrigues-Lima Fernando, Dupret Jean-Marie, Baeza-Squiban Armelle, Boland Sonja, Intracellular Signal Modulation by Nanomaterials, in Nanomaterial, 811, 2014. Crossref

  7. Lison D., van den Brule S., Van Maele-Fabry G., Cobalt and its compounds: update on genotoxic and carcinogenic activities, Critical Reviews in Toxicology, 48, 7, 2018. Crossref

  8. Lu Jiafeng, Xue Ying, Wang Yuhang, Ding Yang, Zou Qinyan, Pan Min, Qiao Longwei, Zhang Chunhua, Ge Qinyu, Wang Ting, Li Hong, RETRACTED ARTICLE: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model, Cell and Tissue Research, 381, 1, 2020. Crossref

Digitales Portal Digitale Bibliothek eBooks Zeitschriften Referenzen und Berichte Forschungssammlungen Preise und Aborichtlinien Begell House Kontakt Language English 中文 Русский Português German French Spain